ID A0A0A2WIF6_BEABA Unreviewed; 609 AA.
AC A0A0A2WIF6;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=tRNA pseudouridine synthase 1 {ECO:0000313|EMBL:KGQ12904.1};
GN ORFNames=BBAD15_g1339 {ECO:0000313|EMBL:KGQ12904.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ12904.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ12904.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ12904.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ12904.1}.
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DR EMBL; ANFO01000076; KGQ12904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2WIF6; -.
DR STRING; 1245745.A0A0A2WIF6; -.
DR eggNOG; KOG2553; Eukaryota.
DR HOGENOM; CLU_021971_1_0_1; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:1990481; P:mRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 400..506
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 17..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..609
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 172
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 228
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
SQ SEQUENCE 609 AA; 68680 MW; EE434CF657534A60 CRC64;
MLPIPIASLR TRVNATMATN GESSADIPPA GGRNDSRQDR KQRFGGSRFN SNNQRKKGRG
GKSSDNKRGE KREGASDWRE YKRRKVDSAG EVIEAKNPFS KDEIAAEERR PKRKVAVMIG
YSGTGYKGMQ VNGDEPTIER DLFQAFIKAG AISKANADDP RKSSLARCAR TDKGVHAAGN
VISLKLIIED EDIVDKINAA LPEQIRIWGI QRTNNSFNCY QYCDSRFYEY LLPSYCLLPP
HPQTFLGQKL VELNKEYGYE DEYHASMADV KNFWAEVEEN DIKPILAKLD PEVRAAVLER
IHSIDDPEAA KEEAAKEEAA KEEAVQEEPK NDELVAEEAP ATNAEPEAAA ANPVVLTSTK
PKGRELGPVD FALRDIKAAY INAKRRYRIT PARRERLQEA LDKYTGTRNF HNYTVQKAYG
DPSAKRTIKS FKVNPTPVLI NNTEWLSLKV HGQSFMMHQI RKMVGLVSLM VRCGTPLERM
DESYQNHKMA IPKAPGLGLL LEHPVFTNFN RRATDNLGRD EIDFEKYADK MGAFKDKEIY
QRIFDVEEKE NTFHAFFNQI DQFKANHFLW LTAGGLKVAE IAKEESGKEE DVDKQLGDED
EEDPDGGQG
//
