ID A0A0A6UIK8_ACTUT Unreviewed; 632 AA.
AC A0A0A6UIK8;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:KHD75266.1};
GN ORFNames=MB27_23650 {ECO:0000313|EMBL:KHD75266.1};
OS Actinoplanes utahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1869 {ECO:0000313|EMBL:KHD75266.1, ECO:0000313|Proteomes:UP000054537};
RN [1] {ECO:0000313|EMBL:KHD75266.1, ECO:0000313|Proteomes:UP000054537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 12052 {ECO:0000313|EMBL:KHD75266.1,
RC ECO:0000313|Proteomes:UP000054537};
RA Velasco-Bucheli B., del Cerro C., Hormigo D., Garcia J.L., Acebal C.,
RA Arroyo M., de la Mata I.;
RT "Draft genome sequence of Actinoplanes utahensis NRRL 12052.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHD75266.1}.
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DR EMBL; JRTT01000029; KHD75266.1; -; Genomic_DNA.
DR RefSeq; WP_043527753.1; NZ_JRTT01000029.1.
DR AlphaFoldDB; A0A0A6UIK8; -.
DR STRING; 1869.MB27_23650; -.
DR eggNOG; COG3962; Bacteria.
DR OMA; PNTYHLE; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000054537; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd02003; TPP_IolD; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KHD75266.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054537};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 61..140
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 227..361
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 422..581
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 612..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 67461 MW; 128DDDA935C3655B CRC64;
MKQRLTVGQA VVRFLANQWT ERDGVEQRAV AGFLGIFGHG NVAGIGQALL QAQRTGESRL
GQSGMPFILA RNEQAMVHTA VGYARMRNRL STMACTASIG PGSTNMLTGA ALATVNRLPV
LLLPSDVFAT RVATPVLQEL EDPRSADVSV NDAFRPLSRF FDRVWRPEQL PAALLGAMRV
LTDPAECGAV TVCLPQDVQA EGYDYPDELF ARRVWHVPRH TPDPLALERA AAVIRGAARP
LIVAGGGVIY SEASAALDRF ARETGIPVAD TQAGKGALNW DHPCAVGGIG ATGSPVANRL
ARHADVVLGV GTRYSDFTTA SRSVFQRPDV RFVNLNVTGF DAGKLSALAL TGDARAGLSA
LLPALHGRRF SADYREQVAA WNRRVDDAYR GRGGSGDLPT QAEVIGVVNE ACGARDVVVQ
AAGSLPGDLQ RLWRARDPKQ YHVEYGYSCM GFEIAGALGI KLADPGREVF ALVGDGSYLM
MAQEIATAVA EGLKLIVVIV QNHGFASIGG LSEQVGSQRF GTAYRYRNPR SGDYDGPRLP
VDLAMNAESL GAAVIRCRGI ADLVEGVKTA RDAARLTVLH IETGPEPSAP SSEAWWDVPV
AEVATLQTTR DAHGGYLAGK RDQRHHLRPG GL
//