ID A0A0A6YXZ1_MOUSE Unreviewed; 1244 AA.
AC A0A0A6YXZ1;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=CLIP associating protein 1 {ECO:0000313|Ensembl:ENSMUSP00000142203.3};
GN Name=Clasp1 {ECO:0000313|Ensembl:ENSMUSP00000142203.3,
GN ECO:0000313|MGI:MGI:1923957};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000142203.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:15345747}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [2] {ECO:0007829|PubMed:16452087}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000142203.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142203.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000142203.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142203.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR AlphaFoldDB; A0A0A6YXZ1; -.
DR jPOST; A0A0A6YXZ1; -.
DR ProteomicsDB; 311958; -.
DR Antibodypedia; 33401; 332 antibodies from 32 providers.
DR Ensembl; ENSMUST00000191823.6; ENSMUSP00000142203.3; ENSMUSG00000064302.15.
DR AGR; MGI:1923957; -.
DR MGI; MGI:1923957; Clasp1.
DR VEuPathDB; HostDB:ENSMUSG00000064302; -.
DR GeneTree; ENSGT00940000154817; -.
DR HOGENOM; CLU_1247868_0_0_1; -.
DR ChiTaRS; Clasp1; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000064302; Expressed in myocardium of ventricle and 250 other cell types or tissues.
DR ExpressionAtlas; A0A0A6YXZ1; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0A6YXZ1,
KW ECO:0007829|MaxQB:A0A0A6YXZ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 87..319
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 594..832
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 995..1233
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 136623 MW; E85DCE496B9C9428 CRC64;
MTTGKEKNFD DEDSVDGNRP SSASSSSSKA PSSSRRNVNL GTTRRLMSSS LGSKSSAAKE
GAGAVDEEDF IKAFDDVPVV QIYSSRDLEE SINKIREILS DDKHDWEQRV NALKKIRSLL
LAGAAEYDNF FQHLRLLDGA FKLSAKDLRS QVVREACITL GHLSSVLGNK FDHGAEAIMP
TIFNLIPNSA KIMATSGVVA VRLIIRHTHI PRLIPVITSN CTSKSVAVRR RCFEFLDLLL
QEWQTHSLER HISVLAETIK KGIHDADSEA RIEARKCYWG FHSHFSREAE HLYHTLESSY
QKALQSHLKN SDSIVSLPQS DRSSSSSQES LNRPLSAKRS PTGSTASRGS TVSTKSVSTT
GSLQRSRSDI DVNAAASAKS KVSSSSGSPA FSSAAALPPG SYASLDGTTT KAEGRIRTRR
QSSGSTTNVA STPSDSRGRS RAKVVSQSQR SRSANPAGAG SRSSSPGKLL GSGLAGGSSR
GPPVTPSSEK RSKIPRSQGC SRETSPNRIG LDRFGLGQSG RIPGSVNAMR VLSTSTDLEA
AVADALLLGD ARSKKPVRRR YEPYGMYSDD DANSDASSVC SERSYGSRNG GIPHYLRQTE
DVAEVLNHCA SSNWSERKEG LLGLQNLLKS QRTLSRVELK RLCEIFTRMF ADPHSKRVFS
MFLETLVDFI IIHKDDLQDW LFVLLTQLLK KMGADLLGSV QAKVQKALDV TRDSFPFDQQ
FNILMRFIVD QTQTPNLKVK VAILKYIESL ARQMDPTDFV NSSETRLAVS RIITWTTEPK
SSDVRKAAQI VLISLFELNT PEFTMLLGAL PKTFQDGATK LLHNHLKNSS NTGVGSPSNT
IGRTPSRHPS SRTSPLTSPT NCSHGGLSPS MLDYDTENLN SEEIYSSLRG VTEAIEKFSF
RSQEDLNEPI KRDGKKDCDI VSRDGGAASP ATEGRGGSEI EGGRMALDNK TSLLNTQPPR
AFPGPRAREY NPYPYSDTIN TYDKTALKEA VFDDDMEQLR DVPIDHSDLV ADLLKELSNH
NERVEERKGA LLELLKITRE DSLGVWEEHF KTILLLLLET LGDKDHSIRA LALRVLREIL
RNQPARFKNY AELTIMKTLE AHKDSHKEVV RAAEEAASTL ASSIHPEQCI KVLCPIIQTA
DYPINLAAIK MQTKVVERIT KESLLQLLVD IIPGLLQGYD NTESSVRKAS VFCLVAIYSV
IGEDLKPHLA QLTGSKMKLL NLYIKRAQTT NSNSSSSSDV STHS
//
