ID A0A0A7FU40_9CLOT Unreviewed; 615 AA.
AC A0A0A7FU40;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=U729_709 {ECO:0000313|EMBL:AIY82316.1};
OS Clostridium baratii str. Sullivan.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1415775 {ECO:0000313|EMBL:AIY82316.1, ECO:0000313|Proteomes:UP000030635};
RN [1] {ECO:0000313|EMBL:AIY82316.1, ECO:0000313|Proteomes:UP000030635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sullivan {ECO:0000313|EMBL:AIY82316.1};
RX PubMed=25489752; DOI=10.1016/j.meegid.2014.12.002;
RA Smith T.J., Hill K.K., Xie G., Foley B.T., Williamson C.H., Foster J.T.,
RA Johnson S.L., Chertkov O., Teshima H., Gibbons H.S., Johnsky L.A.,
RA Karavis M.A., Smith L.A.;
RT "Genomic sequences of six botulinum neurotoxin-producing strains
RT representing three clostridial species illustrate the mobility and
RT diversity of botulinum neurotoxin genes.";
RL Infect. Genet. Evol. 30:102-113(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CP006905; AIY82316.1; -; Genomic_DNA.
DR RefSeq; WP_039311681.1; NZ_CP006905.1.
DR AlphaFoldDB; A0A0A7FU40; -.
DR STRING; 1561.NPD11_2297; -.
DR KEGG; cbv:U729_709; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_020160_0_0_9; -.
DR OrthoDB; 9763537at2; -.
DR Proteomes; UP000030635; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06565; GH20_GcnA-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AIY82316.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030635}.
FT DOMAIN 2..126
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 130..364
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 284
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 615 AA; 72179 MW; 4E7C559F3F106890 CRC64;
MYLIPRPKEY KETLEQFIIN KKTKIVLSST CTSNELETAL ILKEAIKDES GITLNITKSF
KEGYSENEIR IIIDNLLEKE EYKLNIKDKY IEIIGSESSG VYYGIQTLIQ ILKQDGIRLR
GINIEDSPYF KNRGYFADIT RGKVPSLESL KKLVDKLSFY KVNQMQLYIE HTFAFKDMSE
VWRDKDPITA EEILILDEYC KKRHIELIPS LATFGHLYEV LRTKSYEDLC ELENSREGEY
SYIDRMAHHT LDVSNNKSLE LVYNMLNEFI PLFSSNKFNI CCDETFDLGK GKSKDIAEKI
GSGKLYVDFL NKVTSFVKKY DKTVLFWGDV ILNHKELLKD IPEDTICLNW DYWCKATENN
TRIIWESKRK QWVCPGTGGW SHLMNLIENS FENINRMVSY GVKYGAEGIL NTDWGDYGHI
NLLSNSVPSI IYGASLSWNP NIEKDFDYEY KAISLLEYGD ESLQLVNELK ELSECQTVGW
SELIWWKERF SDKVKADFKK LDPYEIKESY EKAKEIEERL LILSTKLKNK ESTQDFILAA
NGIALINDFF LTLLKEEFNK NEVDTFNTPK DLARDFEEWL YDYSIKWREN NKESELYRIR
DVIIYVCDYL RDIKE
//
