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Database: UniProt
Entry: A0A0A7I061_9BIFI
LinkDB: A0A0A7I061_9BIFI
Original site: A0A0A7I061_9BIFI 
ID   A0A0A7I061_9BIFI        Unreviewed;       491 AA.
AC   A0A0A7I061;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-SEP-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AH68_00005 {ECO:0000313|EMBL:AIZ13658.1};
OS   Bifidobacterium kashiwanohense PV20-2.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=1447716 {ECO:0000313|EMBL:AIZ13658.1, ECO:0000313|Proteomes:UP000030625};
RN   [1] {ECO:0000313|EMBL:AIZ13658.1, ECO:0000313|Proteomes:UP000030625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PV20-2 {ECO:0000313|EMBL:AIZ13658.1,
RC   ECO:0000313|Proteomes:UP000030625};
RX   PubMed=25614572;
RA   Vazquez-Gutierrez P., Lacroix C., Chassard C., Klumpp J., Jans C.,
RA   Stevens M.J.;
RT   "Complete and Assembled Genome Sequence of Bifidobacterium
RT   kashiwanohense PV20-2, Isolated from the Feces of an Anemic Kenyan
RT   Infant.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007456; AIZ13658.1; -; Genomic_DNA.
DR   RefSeq; WP_039196488.1; NZ_CP007456.1.
DR   EnsemblBacteria; AIZ13658; AIZ13658; AH68_00005.
DR   KEGG; bka:AH68_00005; -.
DR   KO; K02313; -.
DR   Proteomes; UP000030625; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030625};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      181    320       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      394    463       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     189    196       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   491 AA;  55161 MW;  4590EC53A36B01B9 CRC64;
     MADTTTDPLD QARGVWSDAL ALLHQNPALS VRDKSWLENV FPEGMWGPTI VLCVPSAAAQ
     QTLQNELSQP LLKALREAAE QDIFPAFKIV EKKEPAQPVV EEYPHFTPAP HVEETTQGQL
     PIPVVMPPER PNTFQRGQNR PLLDPKTHLN KNATFDTFVP GDSNRFARTV ALAVAEGSGH
     DFNPLCIYGG SGLGKTHLLN AIGNYALVKD PSLKVRYVTS EEFTNEFIEA LGDTNQNSGQ
     IKEFNRRYRE VDVLLIDDIQ FLSGKDATLE QFFHTFNTLH QANKRIVIAS DVPPKDLQGF
     NERLISRFES GLTVDVKPPD LETRIAILRM IAHESNVQDD VLNLIAERFT ENIRELEGAL
     NRVTAMASLS GQPVTRALAE HTLQDFFATD VEIKPTDIIT QVAKYFYITF DDIVGRSRTK
     KIALARQIAM YLVRELTSMS LNDIGQVFGG KDHTTVMHAY TRISDEMQEK QEIYNYVTEL
     TLQLKQRSGE K
//
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