UniProt: A0A0A7V0X6

Database: UniProt
Entry: A0A0A7V0X6_9ARCH

LinkDB:  A0A0A7V0X6_9ARCH 
Original site:  A0A0A7V0X6_9ARCH

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (15)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (27)   

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ID   A0A0A7V0X6_9ARCH        Unreviewed;       420 AA.
AC   A0A0A7V0X6;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|ARBA:ARBA00013255, ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|ARBA:ARBA00013255, ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|ARBA:ARBA00042864, ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=glycinamide ribonucleotide synthetase {ECO:0000256|ARBA:ARBA00042242, ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:AJA92662.1};
GN   ORFNames=A7X95_02480 {ECO:0000313|EMBL:PTL88157.1}, T478_0922
GN   {ECO:0000313|EMBL:AJA92662.1};
OS   Candidatus Nitrosopelagicus brevis.
OC   Archaea; Nitrososphaerota.
OX   NCBI_TaxID=1410606 {ECO:0000313|EMBL:AJA92662.1, ECO:0000313|Proteomes:UP000030944};
RN   [1] {ECO:0000313|EMBL:AJA92662.1, ECO:0000313|Proteomes:UP000030944}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CN25 {ECO:0000313|EMBL:AJA92662.1}, and V2
RC   {ECO:0000313|Proteomes:UP000030944};
RX   PubMed=25587132; DOI=10.1073/pnas.1416223112;
RA   Santoro A.E., Dupont C.L., Richter R.A., Craig M.T., Carini P.,
RA   McIlvin M.R., Yang Y., Orsi W.D., Moran D.M., Saito M.A.;
RT   "Genomic and proteomic characterization of "Candidatus Nitrosopelagicus
RT   brevis": An ammonia-oxidizing archaeon from the open ocean.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:1173-1178(2015).
RN   [2] {ECO:0000313|Proteomes:UP000241022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U25 {ECO:0000313|Proteomes:UP000241022};
RA   Dupont C., Santoro A.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:PTL88157.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U25 {ECO:0000313|EMBL:PTL88157.1};
RA   Lavstsen T., Jespersen J.S.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:PTL88157.1, ECO:0000313|Proteomes:UP000241022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U25 {ECO:0000313|EMBL:PTL88157.1,
RC   ECO:0000313|Proteomes:UP000241022};
RA   Carini P.;
RT   "Transcriptomics of ammonia oxidizing archaea.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681,
CC         ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-
CC       (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-
CC       diphosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005174,
CC       ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|ARBA:ARBA00038345,
CC       ECO:0000256|HAMAP-Rule:MF_00138}.
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DR   EMBL; CP007026; AJA92662.1; -; Genomic_DNA.
DR   EMBL; LXWN01000001; PTL88157.1; -; Genomic_DNA.
DR   RefSeq; WP_048105510.1; NZ_LXWN01000001.1.
DR   STRING; 1410606.T478_0922; -.
DR   GeneID; 24816813; -.
DR   KEGG; nbv:T478_0922; -.
DR   HOGENOM; CLU_027420_3_1_2; -.
DR   OrthoDB; 146558at2157; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000030944; Chromosome.
DR   Proteomes; UP000241022; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 3.90.600.10; Phosphoribosylglycinamide synthetase, C-terminal domain; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   NCBIfam; TIGR00877; purD; 1.
DR   PANTHER; PTHR43472; PHOSPHORIBOSYLAMINE--GLYCINE LIGASE; 1.
DR   PANTHER; PTHR43472:SF1; PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC; 1.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01209; GARS_A; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00138};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, ECO:0000256|HAMAP-
KW   Rule:MF_00138}; Reference proteome {ECO:0000313|Proteomes:UP000030944}.
FT   DOMAIN          104..310
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
SQ   SEQUENCE   420 AA;  45825 MW;  405D43290497D9A8 CRC64;
     MVNVLVVGAG GREHALSWKL STSEKIDQVY AAPGNGGTLQ NVELSVTDIE GLAKFAQEKN
     CFTVVGPEDP LATGIVDAFV EKGLPIFGPT KNAAKLESSK IWAKEFMKRN SIPTADFEIF
     DDAQKAKDFV KSYEKPVVIK ADGLAAGKGV IVCKNKDEAN DAIDTILIKK SFGDAGSKII
     IEERIDGVEA SYIALCDGKI GIPMATSQDH KRVFDNDEGP NTGGMGAYSP TPIIDEKLGT
     EIQEKIIDKT IHAMRDEGFE FKGFLYAGIM IKDGIPYVLE YNVRMGDPEC QPILMRLDSD
     LYDYLHASYE GKLNELPEIS WKNQYSVCVV LASKGYPSSY PTGDEITGFE NISSDAFVFH
     AGTKKQDDKI KSNGGRVLGV TALGSSLQDA INNAYDACNH IHWTNKYHRT DIGKKGLSNL
//

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