ID A0A0A8E6P4_9GAMM Unreviewed; 289 AA.
AC A0A0A8E6P4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN ORFNames=SD28_06335 {ECO:0000313|EMBL:AJC49272.1};
OS Allofrancisella guangzhouensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Allofrancisella.
OX NCBI_TaxID=594679 {ECO:0000313|EMBL:AJC49272.1, ECO:0000313|Proteomes:UP000031104};
RN [1] {ECO:0000313|EMBL:AJC49272.1, ECO:0000313|Proteomes:UP000031104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=08HL01032 {ECO:0000313|EMBL:AJC49272.1,
RC ECO:0000313|Proteomes:UP000031104};
RA Svensson D., Ohrman C., Backman S., Karlsson E., Nilsson E., Bystrom M.,
RA Larkeryd A., Stenberg P., Scholtz H.C., Forsman M., Sjodin A.;
RT "Complete genome sequence of Francisella guanzhouensis strain 08HL01032
RT isolated from air-conditioning system in China.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009, ECO:0000256|RuleBase:RU361140}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP010427; AJC49272.1; -; Genomic_DNA.
DR RefSeq; WP_039125175.1; NZ_JACVKK010000056.1.
DR AlphaFoldDB; A0A0A8E6P4; -.
DR STRING; 594679.SD28_06335; -.
DR MEROPS; S11.A01; -.
DR KEGG; fgu:SD28_06335; -.
DR HOGENOM; CLU_031960_6_0_6; -.
DR OrthoDB; 9784149at2; -.
DR Proteomes; UP000031104; Chromosome.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR023650; Beta-lactam_class-A_AS.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|RuleBase:RU361140};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..289
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002036296"
FT DOMAIN 41..257
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 289 AA; 32987 MW; D2A2A2C40A5C920A CRC64;
MKKLIIILAN LLHSVVFATL NNVETSEQIK KLEIKYGGKI GIYLIDYNNK SHFGYNQNFY
FPICSVYKFL VVGAILKESM ITPNFLNEKI KINKNDIIGY TPITSENIDK KLTIEELSKA
AILSDNTAAN LLIKKLGGLK NLNKFIWSLD DKDTKITVNE PTINNVDLRD SLNKTTPQII
AKDLNKIAFE KKVLNKKYQL IFKKWLQEND TGKNRIAFSI PKEWKVGDKT GTCEYGTTND
VAIIWPKNKK PIIISVLYTQ VNKNAKANDI VIQKITKILL DNLEYKNND
//