ID A0A0A8E9M6_9COXI Unreviewed; 376 AA.
AC A0A0A8E9M6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=Z664_00955 {ECO:0000313|EMBL:AJC50317.1};
OS Coxiella endosymbiont of Amblyomma americanum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=325775 {ECO:0000313|EMBL:AJC50317.1, ECO:0000313|Proteomes:UP000059222};
RN [1] {ECO:0000313|EMBL:AJC50317.1, ECO:0000313|Proteomes:UP000059222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C904 {ECO:0000313|EMBL:AJC50317.1};
RA Raghavan R., Smith T.A.;
RT "Endosymbiont of Amblyomma americanum.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SUBUNIT: Forms a 24-polypeptide structural core with octahedral
CC symmetry. {ECO:0000256|ARBA:ARBA00011484}.
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP007541; AJC50317.1; -; Genomic_DNA.
DR RefSeq; WP_039669867.1; NZ_CP007541.1.
DR AlphaFoldDB; A0A0A8E9M6; -.
DR STRING; 325775.Z664_00955; -.
DR KEGG; cea:Z664_00955; -.
DR HOGENOM; CLU_016733_10_0_6; -.
DR Proteomes; UP000059222; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF12; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000059222};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 1..76
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 376 AA; 41957 MW; 44614A09A13224EF CRC64;
MKVFKLPDLG EGLPDAIIRE WHVKEGDKVI VDQPLVSMET AKALVDVPSP VSGKIVRLFG
KIGDTIKTDC PLIGFEETFE TKNPEFSTKT ATNVIKSDHV ILKSLDHHVT HKPKRIRSIR
ATPAIRKLAK QLGVDLSKIK PRNSIITSDL VKKAFQLQQI SLQNSNLSNV RQAMAFNMSQ
SHRDVVPVSL SDDADIHIWE SRQDISIRLI RAIEKACITI PIMNAYFDGN KMSYQIKKHI
NIGIAIDTPN GLYVPVLKDI AHKDDNALRQ KINHFKEMAQ TQSLRFEDLQ GATIMLSNFG
MFAGRYANPI VLPPLVTVVG AGRVREQVVP SDNGQPAVHR ILPLSITSDH RIITGGEIAR
FLKELINALE KKKSNL
//
