UniProt: A0A0A8EKB2

Database: UniProt
Entry: A0A0A8EKB2_9ACTN

LinkDB:  A0A0A8EKB2_9ACTN 
Original site:  A0A0A8EKB2_9ACTN

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Ontology (4)   
   GO (4)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (43)   
   InterPro (23)   
   Pfam (10)   
   PROSITE (4)   
   SMART (6)   
All databases (50)   

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ID   A0A0A8EKB2_9ACTN        Unreviewed;      3359 AA.
AC   A0A0A8EKB2;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Type I polyketide synthase {ECO:0000313|EMBL:AJC56293.1};
GN   ORFNames=GZL_03707 {ECO:0000313|EMBL:AJC56293.1};
OS   Streptomyces sp. 769.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1262452 {ECO:0000313|EMBL:AJC56293.1, ECO:0000313|Proteomes:UP000031113};
RN   [1] {ECO:0000313|EMBL:AJC56293.1, ECO:0000313|Proteomes:UP000031113}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=769 {ECO:0000313|EMBL:AJC56293.1,
RC   ECO:0000313|Proteomes:UP000031113};
RA   Du Q., Wang Q., Li Q., Wang L., Zhang Z., Ren J., Wang J., Wang M.;
RT   "Complete Genome Sequence of Streptomyces gongzhulingensis.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP003987; AJC56293.1; -; Genomic_DNA.
DR   RefSeq; WP_039633289.1; NZ_CP003987.1.
DR   KEGG; stre:GZL_03707; -.
DR   HOGENOM; CLU_000022_35_8_11; -.
DR   Proteomes; UP000031113; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          35..459
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1465..1540
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1558..1982
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3205..3280
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3359 AA;  351147 MW;  D899D78D4020BCD4 CRC64;
     MSPTNEDKLR SYLKRAIADL QQTRDRLAEV EAGDREPIAI IGMACRYPGG VGSPEDLWQL
     VASGTDAIAA FPDNRGWDVD GMYHPDPDHA GTTYVRESGF LYDAAEFDPA FFGISPREAM
     AMDPQHRLLL ETSWEALERA GIDPASVRGS RTGVFAGMMY HDYAARLNVV PEGLEGYLGN
     GSAGSIASGR VAYTLGLEGP AVTVDTACSS SLVTLHLAAQ SLRKGECTLA LAGGVTVMSS
     PGSFIEFSRQ RGLSPDGRCK AFSADADGTG WGEGVGMLLV ERLSDARRNG HPVLALVRGS
     AVNQDGASNG LTAPNGPSQR RVIQQALENA NLTAQQVDVV EAHGTGTRLG DPIEAQALLA
     TYGQDRERAL WLGSLKSNIG HTQAAAGVGG VIKMVMALQH GVLPKTLHVD EPTPEVDWSA
     GAVSLLTEQV EWPQTGEPRR AAVSSFGVSG TNAHTILEQA PPVEAQAVAA PAPGVVPAVV
     PWVVSGKTEA ALRAQASRLL SFMDSTPELN PADIGISLAA GRAAFEYRAA VVATDPAAFR
     SGLAALADAG SAPHLVQGVA GGRKVVFVFP GQGSQWVGMA VELLDSSPVF AESMRACAQA
     LAPHVEWSLL DVLADAEALE RVDVVQPVLF AVMVSLAALW RSYGVEPAAV VGHSQGEIAA
     ACVAGALSLD DAARVVALRS KALLALSGRG GMVSVSLPVD EVAERLERWD GRISIAAVNG
     PGSIVVSGDV DALDELLGDC EESGVRARRI PVDYASHSAH VEEIREELLS ILAGISPRPS
     QVPFYSTVTV ERIDTSVLDA EYWYRNLRQT VRFEETVQLL AEQGHRLFVE SSAHPVLAMG
     IQETSEQIVA LGSLRRDEGS LDRFLLSLAE AHVHGATVDW TAVFPGARRV DLPTYAFQRQ
     RYWLDADAPV GEVSVDPVDA RFWAAVEGED LRALADALGV RGDDAAALEA VLPVLSAWRR
     TRRDKSTVDS WRYRIGWQRL PEPASAALSG NWLVVLPTGG AGKWGTAAVA ALEAAGAEVT
     EVELPAETDP GAVAELLSGA APEGVLSLVA LEGTPVGAAN TVSLLQALGT AGIDAPLWCA
     TRGAVAVASG EGPDSPVQAQ VWGLGRVAAL EHPQRWGGLI DLPVDADDAA RRRLVGVLAG
     AGDEDQLAVR AAGLYGRRLE HAPLADRAPS RAWRPSGTVL VTGGTGPLAA QAARWLAENG
     AEHVLLAGPV EKEGEEGGEE GVGGGVAGGE AALEAELANA GARVTIVPCE SDDRATLEKL
     LATPPTAVVH APTVLDQAPL AETTPAEFAA VVDAKAAMAA HLDELLDAHA PDAVVVFFSA
     VAGVWGSGRQ GAYAAGNAYL DALAQRRRAR GLPTTSVAWS PWDGGADTED GFLDFLRRRG
     LRAIDPALAI TALQQVIDHD ETFVALADVD WERFVAGFTA VRPSPLIAGL PEVRRIQAEE
     GETAGAEGSV LAQRLAGKTD LERDRIVLEL VRDQVAAVLG HSAPEAVEVG RAFLELGFDS
     LTAVDLRNRL NAATGLKLPA TLIFDYPTAT ALADYLKTEV LGAPATASAV PAVATGTDEP
     IAIVGMGCRF PGGVTSEEQL WQLISAGTDA ISEFPTDRGW DLDQLVDQDG ERARTSYVGN
     GGFLHDAGEF DPAFFGISPR EALAMDPQHR LLLETSWEAF ERAGVDPNSL RGRPVGVFAG
     TNGQHYAPLL QGAPENLDGY LATGNGASVL SGRVSYTFGL EGPAVTVDTA CSSSLVALHL
     AAQALRQGEC ELALAGGVTV MSTPDMFLEF SRQNGLAADG RSKAFAAAAD GFALAEGVGM
     LLVERLSDAR RNGHPVLAVV RGSAVNQDGA SNGLTAPNGP SQQRVIRQAL ANAGLGTSDV
     DAVEAHGTGT TLGDPIEAQA LLATYGQDRE RALWLGSLKS NIGHTQAAAG VAGVMKMVLA
     MRHGVLPKTL HVDEPTPQVD WSAGAVSLLT EQAEWPRTDA PRRAAVSSFG ISGTNAHVIL
     EEAPPVEALA VAAPAPVPGV VPWVVSGKTE AALRAQASRL LSFMDATPEL NPVDVGLSLA
     AGRAAFEHRA AVVGADLAAF RGGLAALADA TAAPGVVQGT VAGDRAVFVF PGQGAQWVGM
     AVELLDSSPV FADSMRACAE ALAPHIEWSL LDVLADAEAL ERVDVVQPVL FAVMVSLAAL
     WRSYGVEPAA VVGHSQGEIA AACVAGALSL DDAARVVALR SKALLALSGR GGMVSVSLPA
     DEVAERLQRW DGRISIAAVN GPGSIVVSGD VDALDELLAD CEESGVRARR IPVDYASHSA
     HVEEIREELL TILADISPRP SQVPFYSTVT VERIDTSVLD AEYWYRNLRQ TVRFEETVQL
     LAEQGHRLFV ESSAHPVLAM GIQETSEQIV ALGSLRRDEG GLDRFLLSLA EAHVQGATVD
     WTAVFTGARR VNDLPTYAFQ RQRYWLDAPA AASDVASAGL GSTDHPLLGA MVELPDSDGM
     LFSSRLSLAG HPWLADHAVM GSTLLPGTAF VELAVRAGDQ ADCGHVEELT LESPLVLPER
     GGRQLRLSVG ESDATGRRTL GIHSRSEDGG AWVRHASGVL AADAPAAPAP SGGVWPPAGA
     VPIELDDLYG RLAATGYHYG PAFQGLRAAW RHGDEVFADV ALPEERRSDA SRFGLHPALL
     GAAVQAVGLG GFLGDSGQSR LPFLWGGVSL RAVGAAALRV RISPNGQDSV SLAVTDTLGQ
     PVAEVDSLVL RPVTAEQLRA ARAVRHDSLF RVDWAVVPAL PAVAADRWAV LGADQDKLGA
     ALQAAALPVD VFADLAAFDA APVPAVVLAP CTVDSVADAA DTASAVRLAT HKALALAQGW
     LADERFAQSR LVLVTRGAVA TRPGEDVPDL AHAAVWGLIR SAQAEHPDRL VLLDLDEHDA
     SYQALSAALG TDEPRLAVRE GTLYAPRLAR AVASDEVPRA LDQDGTALIT GATGALGGLV
     ARHLVIEHGV RRLVLAGRRG MEAPGAAELA TELTELGATV TMAACDVAER DQLATLLADI
     PEAHPLTAVV HAAGVLDDGV IESLTPERID AVLRPKVDAA LHLHELTQDI DLAAFVLFSS
     AASTFGGPGQ GNYAAANAFL DGLSQRRRAS GLPASSLAWG LWAQRGGMTA HLADEQIDRL
     ERGGMAALST AEGLALFDAA IGSDEAVLVP VRLAPAALRA TEVVPALLRG LVRAPARRTV
     DAGSVPDAAS LRQRLGGLAE AERDRVLIDL VRGQLAAVLG HASPDAIDAG RGFLELGLDS
     LTAVELRNRL NAATGLRLPA TLVFDYPTPS ALTGYLAAEI VPDTANSAAP LLAELARLQG
     ELAAFTANEE SRGQITVRLK ALMASWTDGG ETETEAEADL DTATDDEMFD LIGKEFGIS
//

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