ID A0A0A8HNN6_STAHY Unreviewed; 153 AA.
AC A0A0A8HNN6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Peroxide-responsive repressor PerR {ECO:0000256|ARBA:ARBA00040445};
GN Name=perR {ECO:0000313|EMBL:NJI32347.1};
GN ORFNames=BUZ57_10445 {ECO:0000313|EMBL:RIO43673.1}, GLV83_11875
GN {ECO:0000313|EMBL:NJI32347.1};
OS Staphylococcus hyicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1284 {ECO:0000313|EMBL:RIO43673.1, ECO:0000313|Proteomes:UP000285625};
RN [1] {ECO:0000313|EMBL:RIO43673.1, ECO:0000313|Proteomes:UP000285625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SNUC 5959 {ECO:0000313|EMBL:RIO43673.1,
RC ECO:0000313|Proteomes:UP000285625};
RX PubMed=28066335; DOI=.3389/fmicb.2016.01990;
RA Naushad S., Barkema H.W., Luby C., Condas L.A., Nobrega D.B., Carson D.A.,
RA De Buck J.;
RT "Comprehensive Phylogenetic Analysis of Bovine Non-aureus Staphylococci
RT Species Based on Whole-Genome Sequencing.";
RL Front. Microbiol. 7:1990-1990(2016).
RN [2] {ECO:0000313|EMBL:NJI32347.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1380 {ECO:0000313|EMBL:NJI32347.1};
RA Rhoads D., Shwani A., Adkins P., Calcutt M., Middleton J.;
RT "Whole genome comparisons of Staphylococcus agnetis isolates from cattle
RT and chickens.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit.
CC {ECO:0000256|PIRSR:PIRSR602481-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIO43673.1}.
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DR EMBL; WMFP01000057; NJI32347.1; -; Genomic_DNA.
DR EMBL; QXVO01000039; RIO43673.1; -; Genomic_DNA.
DR RefSeq; WP_039644847.1; NZ_WMFP01000057.1.
DR AlphaFoldDB; A0A0A8HNN6; -.
DR STRING; 1284.SHYC_04535; -.
DR GeneID; 41072735; -.
DR KEGG; shu:SHYC_04535; -.
DR HOGENOM; CLU_096072_4_2_9; -.
DR Proteomes; UP000285625; Unassembled WGS sequence.
DR Proteomes; UP000606275; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202:SF8; PEROXIDE-RESPONSIVE REPRESSOR PERR; 1.
DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|PIRSR:PIRSR602481-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602481-1}.
FT BINDING 102
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 134
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
FT BINDING 142
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 145
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
SQ SEQUENCE 153 AA; 17623 MW; 270AEBE907C7FA56 CRC64;
MAAEMETYEH QLNDSLATLR EAGVRITPQR QAILNFLIHS KTHPTADEIY QSLSPDFPNI
SVATIYNNLK VFKKTGIVKE LTYGDASSRF DFDTQNHYHV ICEKCGKIVD FHYPSLSEIE
KLAQHVTDFN ITHHRMEIYG ICQECKESQD NDE
//
