ID   A0A0A8LDW6_9SACH        Unreviewed;       870 AA.
AC   A0A0A8LDW6;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=KLDO_g4743 {ECO:0000313|EMBL:CDO96545.1};
OS   Kluyveromyces dobzhanskii CBS 2104.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO96545.1, ECO:0000313|Proteomes:UP000031516};
RN   [1] {ECO:0000313|EMBL:CDO96545.1, ECO:0000313|Proteomes:UP000031516}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA   Nystedt B., Astrom S.;
RT   "The genome of Kluyveromyces dobzhanskii.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDO96545.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CCBQ010000047; CDO96545.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A8LDW6; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000031516; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF59; V-TYPE PROTON ATPASE SUBUNIT A, GOLGI ISOFORM; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        453..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        498..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        575..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        605..627
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        668..687
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        771..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        803..826
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
SQ   SEQUENCE   870 AA;  98906 MW;  66CC84457DB28F92 CRC64;
     MVDAEYLSLG ANDEAIFRSA TMTYVELYIP SEVSREVVCI LGNLGAIMFK DMNAGVSAFQ
     RGHVNQIKKY DEIDRLVQYL IVVSGRHREA TWKYTYHPIS IDDPMGTLGS STKSILESLN
     HHTIDSVNDV SDDIIQVESR VRQLDESLIH LKKRLNKLIE ERHVVFETGR FLEVNPGISG
     RIRSSMDVDE FSLTEDQEAQ SDQLSDFSFD LDVDEPARDN MDLAYHNKFM LTGSISRAKV
     PILNKILWRI LRGNLFFHNI PIEEKLLDGD ELVDKDCFVV FTHGDILMKR VRKVVESLNG
     TLFPISTSHA TIQALNEKIS DLEQICTTTE QTLHTELLIV NDQLSIWSVL VKREKYIYAV
     MNLFRQESQA VVAEGWVPTS KLEAVKNALK DFGEVSASAS TAVLSVISTN KSPPTYHKTN
     KFTDAFQSIV DAYGIATYKE VNPGLATIVT FPFMFAIMFG DLGHGFILAL CGLILVVREK
     KFEQMKRGEI FDMAYSGRYV LLLMGLFSMY TGFLYNDIFS LSMTMFKSGW KWPTDFKEGE
     SIEATKVGVY SFGLDYAWHG TENALLFSNS YKMKLSILMG FIHMTYSFMF SLVNYRYKKS
     RVEIVGNFIP GLIFMQSIFG YLSWAIIYKW SKDWIKDKKP APGLLNMLIN MFLSPGVVEE
     PLFRGQSVLQ IFLLLAALVC VPWLLLYKPL ALKKLNQDAI NRGYSDMHEE EIHDRFQEAQ
     ESSEDTMVVA DYSKEHEHAA FDFGDIVIHQ VIHTIEFCLN CISHTASYLR LWALSLAHAQ
     LSTVLWTMTI ANSFSSENSG SPLAVAKVVF LFGMWFVLTV CILVLMEGTS AMLHSLRLHW
     VEAMSKFFEG EGYAYEPFSF DNVEGEIDNE
//