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Database: UniProt
Entry: A0A0B0HK74_9BACI
LinkDB: A0A0B0HK74_9BACI
Original site: A0A0B0HK74_9BACI 
ID   A0A0B0HK74_9BACI        Unreviewed;       369 AA.
AC   A0A0B0HK74;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA_3 {ECO:0000313|EMBL:KHF27866.1};
GN   Synonyms=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LR68_03293 {ECO:0000313|EMBL:KHF27866.1};
OS   Anoxybacillus sp. BCO1.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX   NCBI_TaxID=1548750 {ECO:0000313|EMBL:KHF27866.1, ECO:0000313|Proteomes:UP000030702};
RN   [1] {ECO:0000313|EMBL:KHF27866.1, ECO:0000313|Proteomes:UP000030702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCO1 {ECO:0000313|EMBL:KHF27866.1,
RC   ECO:0000313|Proteomes:UP000030702};
RA   Patel B.K.;
RT   "Draft genome sequence of an Anoxybacillus isolate BCO1 associated
RT   with a thermophilic microbial mat colonising an outflow from a Great
RT   Artesian Basin bore well.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHF27866.1}.
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DR   EMBL; JRLC01000029; KHF27866.1; -; Genomic_DNA.
DR   EnsemblBacteria; KHF27866; KHF27866; LR68_03293.
DR   PATRIC; fig|1548750.3.peg.3404; -.
DR   Proteomes; UP000030702; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030702};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030702}.
FT   DOMAIN      144    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   369 AA;  42042 MW;  6061FE0F3F1BB08F CRC64;
     MENISDLWNK ALAEIEKKIS KPSFETWLKS TSAHSLKGDI LIITVPNEFT KDWLESRYTR
     LIEQTLYDIT GEELKIKCTI PNHQTLEEFD LKPSSKPRKH DDEQTEFPQS MLNPKYTFDT
     FVIGSGNRFA HAASLAVAEA PAKAYNPLFI YGGVGLGKTH LMHAIGHYVL EHNPSAKVVY
     LSSEKFTNEF INAIRDNRPD DFRNKYRNVD VLLIDDIQFL AGKEQTQEEF FHTFNTLHEE
     SKQIVISSDR PPKEIPTLED RLRSRFEWGL ITDITPPDLE TRIAILRKKA KAEGFDIPNE
     VMLYIANQID SNIRELEGAL IRVVAYSSLI NKEINADLAA EALKDIIPSS KPRVITIQDI
     QRVVGSIST
//
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