ID A0A0B1NZ12_UNCNE Unreviewed; 1371 AA.
AC A0A0B1NZ12;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative dna repair protein rad50 {ECO:0000313|EMBL:KHJ31218.1};
GN ORFNames=EV44_g5766 {ECO:0000313|EMBL:KHJ31218.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ31218.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ31218.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ31218.1}.
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DR EMBL; JNVN01003114; KHJ31218.1; -; Genomic_DNA.
DR STRING; 52586.A0A0B1NZ12; -.
DR HOGENOM; CLU_006184_0_0_1; -.
DR OMA; FSDYYYR; -.
DR OrthoDB; 5477220at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030854};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 67..293
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 265..313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 454..492
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 561..661
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 762..798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 904..976
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1371 AA; 157860 MW; 94E8295E191971CA CRC64;
MFIPTIYLMN ISKAISAISS SNELALCPTG ALNFELIIKT EDFYCPYNCL FFGLKLTFHC
YSAQISRLKI QGIRSFDNQH PEYINFYAPL TLIVGQNGCG KTSIIECLKY ASTGQQPPNT
KGGAFIHDPK LSGEKETLGH VKLEFLNASQ NKLVVSRTIS LTTKKTGVTQ KTLDCTLLMH
NHGERHTMST RVADMDRIVP AQMGVTAAVL DNVIFCHQDD SLWPMAEPQK LKEKFDKIFD
AQKYTKAIEN MIKMRKLHKD ELGKLVIHEA NNKAMKEKAD KVQRRLLSLE AEIDSIRGEI
ETYNLNIKLA SEETKKKKIA SIKALGTIEE LRTKRDRAEG YKSFLATLKA DLEELQDSDE
WLQSTLDKYE ERMAQYHLQS LENQSKIQEL QRAQTASRQA CAEKQTEIGL HQAEQKSYEI
QVETRSQLIR EIAQKYTIKG FEGDLNEDQI SRFMEKFQKL IQEKDRELDQ AKKLTNEKLH
KIRDELTALE NRKAIRIQEK LNSKDAINTN DSRIIERQRE ADAIDVDEGT KAALEASLID
TQQRLSESHA RFEAMSWDKN LKAEDVNLKH LELEASHLKN ELFEINRVSK EQAALEYAKT
QAKNAKRSLE AMIDACNEKL TTVLNQDWTP EKLEKRFQDV LDEKSKALVD ATRKRDLAER
ELLDHEFKLS TICANLKSKT DEIKRCEKVV LSSITTATGQ PLQNIENFLE ELCAIETERD
ELRQDLGSMS VVREYYEKSL TTIRDQNCCR LCERKFANAL EKVSAESKIE NLLKKYVEER
ARQDLEDLEK DLRRANAVRP QYETFNKLFL EIPSIQKEVK DMEIKKLELL AARENWDSIS
NDKMTEKQDI EILSSNVNDI VKYYKENLKY MEEINKLSSQ KKSSSNCLSV QEIQEKSSRC
DEKLHAVRKK IEKLMIDKNN ANSEISSLEI EVGNIKQKLN STEFLLEKKN SLLKAIDELR
EDSKSQRDSM RKADMQLESL IPQFSKIKAM HDDVQRRGEI QAKEIQKDKD KQSQSLNKLV
MVVKDINKYV ENGGPEKLVV CRREIYDLEK AQKSIENEIA QVTQDEKSLN SHINDSEKIK
RSIMSNIRYR KALKDLEITN QEILELEERI RYEDADRLVQ EHLAAETRGQ DLMAERGPLV
GKMGAKDSEL TALIKEWETD YKDAGQKYKE MHIKVETTKA AIEDVIKCIH AVDSAVMKYH
TLKMEEINAI AGDLWTSTYQ GTDIDTIMIR SENETSSTTT TKRNYNYRLC MVKQDAELDM
RGRCSAGQRV LASIIIRLAL AECFGVSCGV IALDEPTTNL DRENINALAE SLNRIIHSRR
RQSNFQLIII THDEEFLQAM KCNEFTDIFW HVSRDAHQKS TIKMESLKEN N
//
