ID A0A0B1P145_UNCNE Unreviewed; 3849 AA.
AC A0A0B1P145;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Putative fat domain-containing protein {ECO:0000313|EMBL:KHJ31953.1};
GN ORFNames=EV44_g2133 {ECO:0000313|EMBL:KHJ31953.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ31953.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ31953.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ31953.1}.
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DR EMBL; JNVN01002453; KHJ31953.1; -; Genomic_DNA.
DR STRING; 52586.A0A0B1P145; -.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000030854}.
FT DOMAIN 2670..3226
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3496..3822
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3817..3849
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2014..2047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3247..3315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3249..3314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3849 AA; 440301 MW; 492047AEE75380CF CRC64;
MSSHGLELLV QRLSSPDSDI KAKYEAAVQL RDNLEHYVAV NIYPAFLKRI VPIFINSLSG
PPVFISTSME QKFRNCILEI IHQLPSTPSE PFEPYAIDIV NLLIELVRID NEENALTSVK
SIMDIMRHQT KVLQDKVQPF LTLIQELFGQ MEAAVNEQLD CLPNAVSHIS GISISYQKPP
RPGSPVNTSV SDLGTDLQQQ TRPLIKGMQS FKVLAECPII VVSLFQLYRT TVPSNVKTFI
PLIKRVLLLQ AKPQEQAHLE AAAKGTNFIG VSPEIRSRVA FAEFITAQVK TMSFLAYLLR
AYSQQLTDFL PNLPIIIVRL LQDCPREKSA ARKELLVAIR HIINFNFRKI FISKIDELLD
ERTLIGDGLT VYETMRPLAY SMLADLIHHV RDSLEPQQIR RTVEVYTKNL QDSFPGTSFQ
TMSAKLLLNM AECISKMKNK ADARHYLIMI LNAIGDKFAS MNRHYANAVK LSSMQSDQIN
EQFSENYLAK NSHPHQWDEI DIFTSMPIKT SISRDRGSDS VTDNKFLFKI LVNGLKNTFY
QLKACNIGTP IDIANAPAIW KEVSYGFSAE EVQVIIKLFR EGSHVFRYFD VEMPTSESQY
STPVEFMANH YMVSSSKEEK DLLETFATVF HCIDPATFHE VFHEEIPRLY DTIFEHTALL
HIPQFFLASE ATSPSFAGML LRFLMSRIHE VGTADVKKSS ILLRLFKLAF MAVTLFSNQN
EQVLLPHVVD IVTKSIELST TAEEPMNYFI LLRSLFRSIG GGKFEHLYKK ILPLIEMLLE
VLNNLLHAAR KPSDRDLYVE LCLTVPARLS NLLPHLSYLM RPLVVALRAG SDIVGQGLRT
LELCVDNLTS DYLDPIMAPV IDDLMTALFD HLRPTPYSHF HAHTTLRILG KLGGRNRKFM
TGAIGLNFQN YSDDVTSFDL RLIGSKKDRA FPAEIGVDLA IRKLMEIPRT TSLKKNDNWY
KKHALHLIKT QVKLRLGFDG YPDDFGRLVL LQAQDLLSRE CHIDLSSLET SDRERSIAKK
YDQDEVLKKL IKACLFAASL PEFTSEITTF MANICKHFTI LQLGRGLAEM RQQSLPFDVN
VKSGEGPLYI DERVLGNAII ESLSSDLSAV REAAQNAIQE IYNSTAIILG SESRVCRLPF
FAYLSNLFCH NCYKEEWFSK TGGCLGINFL ITKINLGDSW VYDRQIDYLR ALMYVIKDMP
SDLPAKTRNT AQLTLEILLN QCTKVMSKVD LQPPPPALTG QRPPQPTKLY QLCTILNTEL
SHMNSYVRET AKRALTIIAR EVGLEIYELL EPSKERCLAP IYSKPLRALP FGVQIGFIDA
VTFYLSLKSD FVKFDDHLNR LLMESLALAD APDESLAGKP AEFRTHESII RLRVACIKIL
STAMGFEGFQ KGQANPTRTK ILSVFFKCLY AESKETIEAA NDALKIFLLQ TSKLPKDLLQ
NSLRPVLAKL QDPRRLSTHG LDALARLLQL LTTYFKVEIG SRLLDHIKVL AEVGMLQRTS
FSLIEQNEQM KIIAAVINIF HLLPPAAEGF KERLIDTTLD LEEGLRRTRH SPFRENLYKY
LNKYPKEIIS FFLKKMEQLK YGRFLAQALE YPDSGPLRDV VYSSLELLLQ SCGDIGEENQ
VTHFSVINII NIIYSLLTAS DEIAKKWINK DHITWLRKAG KNLKNRLQAN ALPSDLRLAA
EQAGDQLMII YIKYLDYHSK DFESLFSLID SVTAHEMKCS QTLFSFLYRT IYSNSVDHWR
QLILRSLEVY ASKTISQKTK AFVLHNLVDP IIAMDVMRHY NISSPTKSPK LLDKTVIESI
HTKIWKAGLG DPNDDLNQPG IDYTRLEVLQ LTAMLVKYHH AILQDARKDI IKFAWTYIRL
EDIINKHAAY VVIGYFIAHY ETPAKIVQQV YFSLLKTNQN EGRALVSQAL ELIAPVLPKR
CSSAPGDRNP IWAAAPRRIL SEESQNIQQM TCIFNFLVRH PDLFFDSRDR FVNLIVGSLR
KIVQPPNPSN DSKKLALNLM TLIWQWEQKR VEGKSPSIRA SSESPKNKKR KIDLPDHSTL
SSTSNITSSE LTDRTEYKIP TMIQTKVIKY LVEFIASLSD RFPLPSAKSR DPLANQNPLQ
VQPSTYMCKK AISLLFNLLQ PQYWGESFVD PLPNVSEQIL ASDRIAAVLS CEYPEKDKPD
EKLLTNIINT LQIVRIIINS KSDSWVLQNM SKLQHILEKP LKSDNPEIQD CLHGDNFEAD
NGKKLRPLLR RILDSIPEDV SMEDADADAD DETEGSKSEL LSFLSSIAME ALSTTTWNYV
SGINILWTLA HWRPSEIDVH INQVIKALQA IAREHVAHWQ AVAGPSGTIT TTRPGEPEAV
GVMTQHDLEI QTGLIFKAID ILSLRMDVLG DNRRPFLSVL ATLIEKSHSN PLCLKILEMV
EGWVFRSDGL SWPTLKEKTA VLHKMLTFEN RSDDTLLAKF LELVIRIYEE PKITRTELTV
RMEHAFLIGT RAVDVDMRNR FMALFDRSQS KTASIRLAYV IIAQNWDTLA DSYWLAQANQ
LLMGSIDLNT TVTFHSEDFR TIPISTLFGT YSNDERVPEL ESKSEFDTLI NSHERFLLEI
EDIRARDIID PLTQLQHLDS DVAHQIWVAL FPIFWSATSK DERGELERGM VTLLTKDYHS
RQIDRRYNVI QTLLEGATRA WPEFKIPPHV LKFEAKTYDA WYTALVHIEN AAIKPEIDSK
LVRESNLDAL VELYAALNED DLFHGTWRRR CQYVETNAAL SYEQNGMWDK AQQMYEQAQI
KARTGALPFS QDEYMLWEDH WVLCATKLQQ WDILADFAKH ENFQDLLLEC AWRQIDNWAS
AENREMLDNV IKGLMDAPTP RRAFFQAFMS LIKLHNKIEP LAEFTKVCDE AIQLAIRKWH
QLPKRTTSAH IPLLQFFQQL VELHDASAIC QSLAQTNQTN LDSKSTELKL LLGTWRDRLP
NVWDDINAWQ DLVTWRQHIF CLINTTYLNL LPVQGNQNAN GTSFAYRGYH ETAWIINRFA
HVARKHQLPE VCINQLGRIY TLPNIEIQEA FLKLREQAKC HYQNSNELSS GLDVINNTNL
NYFGANQKAE FYTLKGMFLE KLGQREEASE AFRMSLFIDV TLAKSWAEWG HYYDRLFKEN
PTDINLAKDA LNCYLEAAGY YKNAKSRKLL TRILWLLSLD DKEGTLSTHF VQFQGDTPVW
YWITFIPQLL TGLSHKEALV THIILCKIAK SYPQALFFQL RTNREEMFTL KRIQEAKEER
ERKLKLLAQS KSHNSPSAPS KTSGPTKITN SDSVAGSPIS PKAENPTVKN EFTTNNEKSN
GKSSENTIEA RPNSSKLMQL GKRPWEHAEE ILAVLKTAFP LLALSMETMV DQIQKHFKCT
PDEDAYRLIG ALLQDALSYV SRAPSSFAQD VKLPSATETN VARFAESILP VHIRASFEAD
FVQKKLTMYE YIHKLRKWRE KCEVKLDRRR PFAYLENYSQ HLSEFKHQKF DEVEVPGQYL
QHRDKNQDFV RIDRFLPIVD LVRNVGVCHR RLKIRGHDGS IHPFAIQHPA ARHCRREERI
VQLFRYFNGI LSKRKESRRR NLNFHLPLMI PLTPHSRMVQ DDATFISLQG VFDDHCRKNG
MSKDDPALFT MDKMKSLIEN RKSHEQIASA RLEIFTAVQE KWVSHTIALN YFSKIYPQFS
DFWLFRKQFS YQFASLTFMT YILHMNNRYP HKLNIARITG NVWGSELMSS LAMGKAYFHN
PEPVPFRLTP NLQTLMGPLA TEGIYSCAIM AIARCLSEPE YELEQQLCLF VRDEMIHWFQ
TSHCSQPVVD VQLKESVQLN SNMIVKRTLS LAQSPAGTLP ANQTVIDLIA RAVSPINLAQ
CDALFMPYL
//
