ID   A0A0B1T2U3_OESDE        Unreviewed;       984 AA.
AC   A0A0B1T2U3;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=SET domain protein {ECO:0000313|EMBL:KHJ89680.1};
GN   ORFNames=OESDEN_10488 {ECO:0000313|EMBL:KHJ89680.1};
OS   Oesophagostomum dentatum (Nodular worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX   NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ89680.1, ECO:0000313|Proteomes:UP000053660};
RN   [1] {ECO:0000313|EMBL:KHJ89680.1, ECO:0000313|Proteomes:UP000053660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ89680.1,
RC   ECO:0000313|Proteomes:UP000053660};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Oesophagostomum dentatum.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN553891; KHJ89680.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B1T2U3; -.
DR   Proteomes; UP000053660; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd00122; MBD; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00391; MBD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50982; MBD; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053660};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          559..633
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   DOMAIN          731..954
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          968..984
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          806..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..828
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..861
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  110732 MW;  C3A65B5C8DC33C60 CRC64;
     MSAQSTSAKP VASYAELGQI VAENMINVIN DPAAQWDVLS EEEIAAIKKK CEELLDWFTY
     LSADDLTDYE VVIPVNYLDK RQDKPCFDPH VMKTVADRFQ ERGDLDFGKE FQMTPEQLIL
     AILCATMEDN NSKDIKFEVL CDALQFDKGT YYMVKKFLSD CDSGSKSPKA LIMQTFCTPI
     DCCLALTMAY CESTSHSYCV KFVDTQIVEE VETGDIAVPT VPMYDPDIKR TNYIGLRVAA
     LVKSTYYFNQ PVWSTGTIGT LPNTAHNKEF LIFFDDGFEE YVQAAFDSGD DDAMRASIIM
     DNRTVVQQFQ EKINLLKILP LAKQSVAANG IDIDKGGVYQ LIRQNPERRR FIQKYFEKYP
     DWPLVRMKKP SPPERPAQAI VAYDRNQDRV TAYVVATDRA LCVLRFPPRN SSVGGANCFE
     YPCTTPGHVH VDETIFRGSS RIHAVNLEHF GNNNMSARRM AKNRSHFDVV QPSPCLDRFK
     ATTTARKSSL PVRTDGGPEG DVLSFELDPQ TLAIRKKKEA QFEVLPCSRP IPQVTWQYHT
     ECSPICLGGL DRDPGDPQFY TCSPLHIPIL CGWKRMLYLY DSSNRRVSDG RILYRAPCGR
     SLVSKKAVAS YLKEVGSELT IDLFCFDPVI ETKTFVHVAD SAVRTPDFTQ GLEQMPIPAI
     NTVDDEDPPK VDSFLFRLVG AKENCLTLSD FRYSFRTLLG KTITGVFECN DNCGCQQKRC
     YNRVVQQPIR YPIQIYKTAQ SGWGVRALCD IPAGAFIANY VGALLTDSLA DALQGEDEYF
     ADLDLNDAVE NEKASTLEKC GYLDMGIGSS DEEEEQPKKG KDADDDGIGS DAASSSSSEE
     DQPKTKRSRR RPEEEMNLRR KKLDAAELEK IDAAAAVGDD TVFKWADYFG ENNTLFVVDA
     KKKGNVGRFL NHSCDPNVQV QHVFVDTHDL RLPWSSFFAI RNIKAGEELC WNYGYSPDAL
     DPDRPRHRQL FCKCGSVNCR GRLL
//