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Database: UniProt
Entry: A0A0B2AK33_9ACTN
LinkDB: A0A0B2AK33_9ACTN
Original site: A0A0B2AK33_9ACTN 
ID   A0A0B2AK33_9ACTN        Unreviewed;       529 AA.
AC   A0A0B2AK33;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   05-JUL-2017, entry version 20.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LK11_71505 {ECO:0000313|EMBL:KHL03980.1};
OS   Mumia flava.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae; Mumia.
OX   NCBI_TaxID=1348852 {ECO:0000313|EMBL:KHL03980.1, ECO:0000313|Proteomes:UP000031002};
RN   [1] {ECO:0000313|EMBL:KHL03980.1, ECO:0000313|Proteomes:UP000031002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 201 {ECO:0000313|EMBL:KHL03980.1,
RC   ECO:0000313|Proteomes:UP000031002};
RA   Lee L.-H.;
RT   "Genome sequence of Mumia flava MUSC 201(T).";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHL03980.1}.
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DR   EMBL; JTDJ01000683; KHL03980.1; -; Genomic_DNA.
DR   EnsemblBacteria; KHL03980; KHL03980; LK11_71505.
DR   Proteomes; UP000031002; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031002};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031002}.
FT   DOMAIN      226    360       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      437    506       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     234    241       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   529 AA;  59114 MW;  3A9E28715B717200 CRC64;
     MQDFWHAASA QLESELTPQQ FKTWIKPLTP LSFDEQACTL RIAAPNRFKL DWVKSQFSGR
     IQSLACDYWE AXVDVQFVLD PTAGQRQAAL QPALAPVPMQ PLGAQAGQPR QAMPTGNGVT
     HDAATLRPAP SVYREAALAT ASHAAADIDV PVMDAAEVSA QSYRIPPQAP AVVTTLAAPP
     QAPVDDSVHE RSRLNQILTF DNFVTGKANQ LARAAAIQVA NNPGKSYNPL YLYGGVGLGK
     THLIHAIGNF MLMENPRARI RYIHAEQYVS DVVKAYQRKA FDDFKRYYHS LDLLLIDDIQ
     FFSGKNRTQE EFFYAFEALI ANRAQVIITS DTYPKEITGI DDRLISRFDS GLTVAIEPPE
     LEMRVAILMK KAQAENVTVP EEVAFFVAKH LRSNVRELEG ALRKILAYSN FHGKEITIEV
     TREALKDLLT VQNRQISVEN IQKTCADFYN IKVADMYSKK RPANIARPRQ IAMYLAKELT
     QKSLPEIGEL FGGRDHTTVL HAVRKIADER TKDAQLNHEL HVLEQTLKG
//
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