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Database: UniProt
Entry: A0A0B2B2I4_9ACTN
LinkDB: A0A0B2B2I4_9ACTN
Original site: A0A0B2B2I4_9ACTN 
ID   A0A0B2B2I4_9ACTN        Unreviewed;       510 AA.
AC   A0A0B2B2I4;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LK11_46115 {ECO:0000313|EMBL:KHL10502.1};
OS   Mumia flava.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae; Mumia.
OX   NCBI_TaxID=1348852 {ECO:0000313|EMBL:KHL10502.1, ECO:0000313|Proteomes:UP000031002};
RN   [1] {ECO:0000313|EMBL:KHL10502.1, ECO:0000313|Proteomes:UP000031002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 201 {ECO:0000313|EMBL:KHL10502.1,
RC   ECO:0000313|Proteomes:UP000031002};
RA   Lee L.-H.;
RT   "Genome sequence of Mumia flava MUSC 201(T).";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHL10502.1}.
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DR   EMBL; JTDJ01000142; KHL10502.1; -; Genomic_DNA.
DR   EnsemblBacteria; KHL10502; KHL10502; LK11_46115.
DR   Proteomes; UP000031002; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031002};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031002}.
FT   DOMAIN      200    328       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      412    481       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     208    215       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   510 AA;  56957 MW;  B122944D41161EF7 CRC64;
     MDDSETQPEA QPVDTAALRS RWEAITDVLP VTTRAWVASS VPLALHDNTL LVAVPNDFTR
     TQMEVRLRSQ LEEALSQSFD RPIRIAVTVD PDALPASRTP TPGSELSTSP HSYEPEPAPE
     PTPPEADEPT HSARDRRPAG DETSPQAAFV PTRPTNRPAQ ANGADTRLNP RYHFENFVIG
     SSNRFAHAAA VAVAEAPGKA YNPLMIYGES GLGKTHLLHA IGHYVRSLYA NARVRYVSTE
     EFTNDFINAI RDDRMPALQR RYRDTDVLLI DDIQFLEGKI QTQEEFFHTF NTLHGSNKQI
     VITSDRPPRG LESLEDRLRS RFEWGLTTDV QPPDLETRIA ILSKKAEIEK LVVPPEVLEF
     IASRIQTNIR ELEGALIRAT AFASLNHQPV DLSLAEIVLK DLIPEGGEPE ITAGLIIAQT
     ANYLEYSIEE ICGASRSRGL VQARQIAMYL CRELTDLSLP KIGQHFGGRD HTTVMYAERK
     IRTLMGERRT VFNHVTELTN RIKQQARQAG
//
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