ID A0A0B2UT55_TOXCA Unreviewed; 943 AA.
AC A0A0B2UT55;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 6 {ECO:0000313|EMBL:KHN72419.1};
GN Name=FGD6 {ECO:0000313|EMBL:KHN72419.1};
GN ORFNames=Tcan_12790 {ECO:0000313|EMBL:KHN72419.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN72419.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN72419.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN72419.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN72419.1}.
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DR EMBL; JPKZ01003252; KHN72419.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2UT55; -.
DR STRING; 6265.A0A0B2UT55; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13389; PH1_FGD5_FGD6; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 379..570
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 599..700
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 775..825
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 104..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 681..708
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 104..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 105253 MW; 9D13BB683D99E2E6 CRC64;
MHEANETCSS GVSVSQIRAR LEGIVFNDKP SPPSAPVNER TSKIVSPLSF ESTVPIVNRS
SLERPPVAPK PQNKVVDAHK WSISSQRAYG AALDRINRRI AALASSVSTE RQDSSSSSNP
ARRSFVDIER SESDGEAACS KTLTNVRSAA AHFDSLISSG LIGAPGGIAR EFDSSASLLS
PSESMIQRPA SETSWSDIRN EASSISSDAE TNSYNDLSDL EDEETLLARD ISFNDPDSMR
PRKKTSVFGS SQLHASALEE LRSRKIFQKD DLRLSERPHM RGKALSNGIP SDVGRLRPQL
PKKSREARYQ PLTVEDAESV LKMRHKSDAG MVPRPSVFAK RASAVSEISV ATTTSTDSHQ
SEVIVYSTGD PAEDMRLKKL HYAALEIYTV EKKFVEQLDV LAVQYPKFIS EYGKARGVSL
LADRSNVISL MASQLLMLKE AHSVLLEKFT AKICNWDSRH PNMAEVLKNN AGFLKFCVPY
LKEKKKFVDE LMKQLQTNEL LAQATSKFEE QATNRISIIQ RLDIVHQNVV RYTILLEAYK
KYLIPDSHEY TECESAIKEL SKVSEVVNHQ MSLAVMEEKL FELYRRLEGH FNVFEANRHL
LHEGELMKQS RKDIQPRYLI LFSDVLLICK YSRAPSLGSD VCFQPDFYQF SILGVRVKAE
EHGEYETHFQ LLSTKKSAVF IAKSKRERDD WVKRLNDAKK EARNLRRISV ARCAKLAGTP
RAPTSATSTA VSEGIAVEKD TSDNDISPTL VHVSEKYVAP WIPDPKATTC MMAGCNTKFN
ILNRRHHCRE CGALICGNCV GHAPVKCGTN FVREKVCPEC FVKITKRCKN KRLGEAQKWG
RLIQHSDGAM VLCFYDAEFD AEPCARHVLL GFHLSSTPLD EGGELFELTH TNQVKGNSIS
ISFRVAHARS AEQWNEALTA GLRAFWTGAT NNNNVDGEQQ SQA
//
