ID A0A0B2UVL7_TOXCA Unreviewed; 551 AA.
AC A0A0B2UVL7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=TWiK family of potassium channels protein 9 {ECO:0000313|EMBL:KHN73132.1};
GN Name=twk-9 {ECO:0000313|EMBL:KHN73132.1};
GN ORFNames=Tcan_09997 {ECO:0000313|EMBL:KHN73132.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN73132.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN73132.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN73132.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN73132.1}.
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DR EMBL; JPKZ01003150; KHN73132.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2UVL7; -.
DR STRING; 6265.A0A0B2UVL7; -.
DR OMA; LSMQWLE; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF273; TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 9; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:KHN73132.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..217
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 302..373
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 530..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 61996 MW; 2105541F8BC9CEA2 CRC64;
MPPIIDRLRN SLSHLGVSLF ALHGALVLGA ALYTVGGALI IRTLESWNDE TTTINRSRRT
IERNAEWGNE NISELSTTAN MDSLATSLLE RYSGSDLSEL QPLVHDCVTR ALETLFNTTN
CNKEDIDRFI IADFDRCYQM AASSAFIEKD ERDVESEEDN KWSLTDSLIF AFTVITTIGY
GNVAPVTFEG RAFLIVYGLI GVPLTLLTIA DLGMFISKMM KFATAIIVKK LMKVKGFIRM
QFMKRKLEDE VNNNIEKPPQ MNGMTANKSN DKRGSIEKST VSDEDINREF LETIALGVTF
FGYLFCGAYI LSLYEPELDF FKAFYFNFIT VTTVGLGDFV PKRETYLLVT IAYITLGLAL
TTLTFDIAAQ YLRKVHYFGR KIENVANAVI WFGGKKMSLK SLVRHLGDHF NIPLDELNNL
NLDTFVDAAI KVEAGEIKTL RKPEPEVVEP PHPVSYQDLR RSCESESLKY ADEWTSISTS
GSEVPLAEET ARTVSSTISK VDQSSIKSED AFRLDRQSAK LKERILRYAK AESEPPAPRR
QSLTSRLKKN I
//
