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Database: UniProt
Entry: A0A0B2V2Q3_TOXCA
LinkDB: A0A0B2V2Q3_TOXCA
Original site: A0A0B2V2Q3_TOXCA 
ID   A0A0B2V2Q3_TOXCA        Unreviewed;      4668 AA.
AC   A0A0B2V2Q3;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   28-FEB-2018, entry version 17.
DE   SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:KHN75295.1};
GN   Name=Rya-r44F {ECO:0000313|EMBL:KHN75295.1};
GN   ORFNames=Tcan_13550 {ECO:0000313|EMBL:KHN75295.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Ascaridida;
OC   Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN75295.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN75295.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN75295.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J.,
RA   Yang Y., Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W.,
RA   Jex A.R., Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHN75295.1}.
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DR   EMBL; JPKZ01002764; KHN75295.1; -; Genomic_DNA.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 2.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 7.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 5.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00449; SPRY; 5.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   PROSITE; PS50188; B302_SPRY; 4.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031036};
KW   Receptor {ECO:0000313|EMBL:KHN75295.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN        1    183       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      555    758       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      806    998       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1378   1582       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4361   4396       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4374   4385       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4668 AA;  526412 MW;  3D6EF9535BC29CD7 CRC64;
     MAVRSSQNTI TQHLLPGKDL LLQTKMRDHV SSMVPKILVG VVDGSAQFRR WYFEAEVEHI
     EQMTNTAPYL RIGWANTVGY KPFPGSGDGW GCNGVGDDFY SYGFDGRCIF FAGKGRVIGN
     APLQKGDIVG CSLDLTIPEI RFTVNGAPTC GCFKNFNIDG YFFPVMSLSA KVSCRFIFGG
     THGRLRFGPP QSFSAIVEAA PCELEVLECL SFGDLQKNTY SGPSTLHHNM EPFVPTPVDI
     SSVILPHFAM DIHEKLAENL HELWAMRKIE LGWTFGEVRD EIQRQHPCLT SFDRLPTNEK
     NYNINLAIDT LKTIDALGYN MVTEKPPTRL RPVRLPQNYQ QSNGYKPQPL DAHEVVLGGE
     MMPLVDALAK NTHNVWAKEK IKRGWTFGLN EFVDSSQKRS PHLVPYELVD QRIKDANRES
     AIEFIRALQL FGIFLEPPVH EHDEGAEKEL KAMCQFSRTY RAEATYAVTS GKWYFEFEVL
     TAGFMKVGWM DVSSQPDTQL GVDDRSYGFD GHLVRKWHQG AESYGREWKI GDIVGSFLDL
     NDRTIAFSLN GELLLFVDSS QKRSPHLVPY ELVDQRIKDA NRESAIEFIR ALQLFGIFLE
     PPVHEHDEGA EKELKAMCQF SRTYRAEATY AVTSGKWYFE FEVLTAGFMK VGWMDVSSQP
     DTQLGVDDRS YGFDGHLVRK WHQGAESYGR EWKIGDIVGS FLDLNDRTIA FSLNGELLLD
     PSGSEVAFDN VIAGDGFVPA MTLGPGQKAR LNFGQDSNTL KYFTTSGLQE GYEPFCVNMY
     RQMPLWYGKR LSLFEDIGPN SSIEVSRIPA TGNSPPCLKL MQKIDSSDTA APEKAKMEYI
     RLSLPVKCSA EKELKAMCQF SRTYRAEATY AVTSGKWYFE FEVLTAGFMK VGWMDVSSQP
     DTQLGVDDRS YGFDGHLVRK WHQGAESYGR EWKIGDIVGS FLDLNDRTIA FSLNGELLLD
     PSGSEVAFDN VIAGDGFVPA MTLGPGQKAR LNFGQDSNTL KYFTTSGLQE GYEPFCVNMY
     RQMPLWYGKR LSLFEDIGPN SSIEVSRIPA TGNSPPCLKL MQKIDSSDTA APEKAKMEYI
     RLSLPVKCSK VFKGKDKEAV MRAIHELQAR QSGVQMVIKG TTIPKEFEDS KEPLKKSLGR
     SLLSAFKHSE DDDIVLPGKS KQASFEEGPG EVTENPAISQ RRRLITLLDY GVCSIDDTIL
     TWLPLDGEDA DELNEWIDAA QSQRRRLITL LDYGVCSIDD TILTWLPLDG EDADELNEWI
     DAAQRPVSLI DMTNDERTVM MDKMKDINGK GLQQKKTGLM ARFREGHQKK KSAETTPVES
     KRTTSTHPPT LQNIGTKTST SLDASSIEAE NIASSAASKD MLSHDMPLSG PGRQSMLKKG
     SLKKKKKKEA AQASPIPHAS LLMENRRPSI LALETGPAAA EGSVPEDDVQ AMNELADQID
     EFYYGVRIFP GQDPASVWIG WVTPKYHFHS PNFNLSEAVR RCRFQEIDQY GNSMQSLEYR
     NCYVMNAAAL LQAVPDAANT KVSGLLIGCI IDTSIGELSF LAAGQDTGIR FRLEPGAMLY
     PAAFVAPTSS EILQFELGRI KYTFPLSSAM FKSTRKSLIP FCPPRLTVEK LQPFHWARVP
     NECLRTTALK LSDVRGWSVL CDDPVRIMSI YVPEKDMSYD ILEIIEQPSC LTFHRQTLNL
     YCKLAAHGNQ KVAHILCAHV DEDQIMYAVK SHYLSGPMRQ GFHDFLIAVH LKTHVDARIS
     AAHEYVVPLV KELRTRNVFA PNSEDRFPQI YGKSVSIRPV MVCNEVQTVF GRDDEMRLLS
     PQFNFAALKA HVMSALKSAI EHAVINCRDL IGGNDLNHFE PLFKLFNSLL VVGLIEDDDL
     KYVLKLIHPS AFDENYEPGT KQKGLTEVDM AEGVKIQLVN ILDNICDIQL RHRIESLVAF
     CEGFVGDLQQ DQCARYMEIK QTDMPPAEAA RRTKEFRCPP KEQMFRLLKC KVAADNSVGI
     IMDDDVEFDQ CPMDESLQEQ LREFCSLLVS KIGCAQEEIN TDLDLIPLED ENSWVDNLAQ
     LVIKVPPAPA QKDDSVEHMG TENFRRMIVN MLKSWSAGSV IENNTLIRQM FNLLLRQYSG
     VAELMTAMSK TYVLHERNVN DVQNFIEYLM QVRELLNVQF ESAEEAVLKR GLWQLMNNRI
     FFQHPDLMRL LKVHEDVMTI MMNILTAQQG TAEHAEHEGS EQATAGQPIK DASEMVVACS
     RFLCYFCRTS RQNQKAMFEH LSFLLDNATM LLARPSLRGS VPLDVAYSSF MDNNELALAL
     KEEELDKVAV YLSRCGLQPN SELVAKGYPD LGWDPVEGER YIDFLRFCVW INGESVEENA
     NLVIRLLIRR PECLGVALKG EGQGLFSAFK EAIALSEDIR ALEEEEDVHM LTSGILGDNP
     HYPSKETEEE DYIDLGAATL DFYSSLVDLL AKCAPDPLTI QAGKGDSLRA RAILRSLISL
     DDLGQILSLR FTIPNLTTTA PIDEDVPSKL HPSDTFPIHR LSSLHGKKIT SASAESTLTP
     QHSQAATATS ITSAIATARY ANAAEDEDFV DADVSSTSSV YTSAGEETPR RSPFLHRSRP
     SQVSVMSNAI GKKPRRSVNL YIGPLPGLLP NHKQSVLLFL DRVYGIDSQE MLFQLLEQSF
     LPDLRAATMM DSPRALESDN ALALNRYLCN AVLPLLTNHS HFFADAEHHA ALLDATLHTV
     YRMNRLQSLT KNQRDAVSDF LVAITRELPP AMMVKLMRKV IIDIKEMTEN VLVPLRIITL
     HYERCTKYYG SGNSYGVASE VEKRLSMLLF DAIFDSLGSK PYDPELFGKA LPCLTAIGSA
     ISPDYALTVV GEDAEMVKAR IDNGVWVPKP VDVSKYELNN ELIAMTAKFA EHFHDSWSTR
     KLEKGWRHGE LYSRQNLTHP RLKPFDLLKD FEKQFYKDRC SECIRALLAW NYQIELSDHD
     AAEKAANSHT SSGTSIENFN PRPVDLSTMT LEKDMMSAAE KMAEHSHNIW AKKVFNDLAT
     KGGNMPIVLV PWDLLTDFER RKDRFRAAEI LKFLRYHGYR VCCMRDSEPS TERIKMEGER
     STVEKRFAYN LLEKLIQYLD QASVKMKTVK PSQELSRRNS FKKEGQDVKF FEKVVLPLMH
     AYFNAHRNYF LASSSIVQTG TASNKEKEMI ANLFCRLASL LRIKNHAFGS VAKITVRCLQ
     GLTQALDLRT LVKANSDIVR TSLLTFFNNC ADDLYIAVKE LKDGGQYSLL RGQNLTSWVS
     LEFAYQMIIP VLTTMFAHLA VNHFGTDLLV DEIQAACYKI LDSAYLLTSL SGTSTERTSI
     GYETDKHRPG LGQCLSAFAA CFPVAFLEAQ YNKYNKYSVL AKTMDQSVQV QEMLQNLAAH
     IPMLESLLTD IEQASLNGTM YRDKPNVFDV DLPLMSSYLT YWWQMGPDGG SKSTQPTTDV
     TSEHMNRIFC ALLRMMRDHV GIENAPWLCR VNFFAVQIIQ HVTCDPVKDF LLPIAERLRR
     IVEKAYKDEE HMRTHPDDAD EGTVAEDNAR LVRDVYAFFP ILMKYCDLHR AQWLKQPSWE
     TDGIYENVAV IFKIWSLSQH FKREELNFMA QYEEGVLAAG ASEMKTGKAA IAERKKKRRE
     GQVRKDKHAN SIVIACLKRL LPVGLNVFGG RELDIVQQTK EKFLAKESEE KIREFVRSLL
     DIPVKTDPTD KNAWQLNLYR KIGKSQMRGK EEMTQDAVVE KIINMGQVVA ILHTDPTDKN
     AWQLNLYRKI GKSQMRGKEE MTQDAVVEKI INMGQVVAIL HVTENPQASL SNAWKKMISN
     QRKRAVVACF RMVALYGIPR AAIHLLCLVL LLRFRTSLST GLNSGQVTSR LEKEDRWKKV
     LTLQRKRMAI SLITASHLYR VDKAAIHLLC LVLLLRFRTS LSTGLNSGQV TSRLEKEDRW
     KKVLTLQRKR MAISLITASH LYRVDKHRAI NFFMPAFSKL WLEEEDVGQD KLIEELTAAE
     EEQEQTHVKY SDDDVLMIDE NREEKEQARP DPLSQLIQCF QRAATSEQNQ TSSIADDTLY
     VYFARVMSKS VHIEEEDDQG EEDGELDQAQ KEEISQALRA EQAVLADRGA AIMCLMYLSA
     SNGEPSEMVA ETLQLGIHLL SGGNIDIQKM LINYLQLKKD VRFFTSLAGL MNKCSVLNLE
     MFERQIKASH AEGLGMGAEL AAGDNQNLND AEFTCSLFRF LQLTCEGHNL DFQNYLRTQP
     GHTTSVNLIN CTVDYLLRLQ ESVMDFYWHY SSKEVIDEGG KEYFLRAIQV CSQVFNTLTE
     SIQGPCVGNQ MTLANSRLWD AINGFFFLFA HMMEKLYKNS TQLELLREFL NLQKDMIVLM
     LSMLEGNVLN GSIGKQMVDA LVESQQCVEM ILKFSDMFLK LKDLTTSQAF QDFDTNRDGW
     ISPKEFQRAM ESQKMYTVQL SQTIKTGYSY GVTAASALRP ANVSKSLKNA ADKIRSMTWA
     QLVFEISKLA FRGGCKLAIA LYLAACTIFR FGYFLMTANK DEEEMEQAAL PMPESQASRL
     QAQHSMEIPS YRQHSSREYD IFGVHMHSEV DQPPAPQFYA AEAEHAQPSP ASQTEALRSP
     VTSQQPQSDV QSVGSAAFVG MPISQAGSEF GSAADYYEPK IAEQGSCRSR GSILNMLARN
     FKTIEKTTLY LAFFINVILL FHRVDITHNQ VSGKLLFPYT VIVHCHNQ
//
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