ID A0A0B2VDR6_TOXCA Unreviewed; 1833 AA.
AC A0A0B2VDR6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:KHN81661.1};
DE Flags: Fragment;
GN Name=NALCN {ECO:0000313|EMBL:KHN81661.1};
GN ORFNames=Tcan_03468 {ECO:0000313|EMBL:KHN81661.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN81661.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN81661.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN81661.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN81661.1}.
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DR EMBL; JPKZ01001479; KHN81661.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2VDR6; -.
DR OMA; LKRIRAX; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF2; PROTEIN CBR-NCA-1; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1106..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1264..1284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1296..1313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1419..1437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..305
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 359..583
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 856..1136
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1186..1456
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KHN81661.1"
SQ SEQUENCE 1833 AA; 211135 MW; 4CAA640D9F1F21BC CRC64;
ADFLQSELAE NALKVACVIS LVTVCVHTPV TLQYFWPLSY IIFIMDFIST IILSAEAIIR
LNAYGMFARN ESYFRDRWSQ FDFFLLIFHW LSLLLHAYER ITKLFPGMGL VYYEWYGVVR
CVRPLIIIRL IRLVLKFKLP KNRIQQLLKR SSQQVQNVTT FFVFFMALYA ILGIQVFGRM
DYHCILKDAD PRNITIADLA IPDTMCSMKG EGGYECPDNM VCEKIKMTAK EEGFYGMFNN
FGASVFTVYL AASEEGWVYV LYDCMDSLPS YWAFLYFVTL IFFLAWLVKN VFIAVITETF
AEIRVQFSEM WQKNEVTFDD GLKQRLEATE EGWKLVKFDS EKSKKTDGPF GLQRILRSTA
FQCFITGIVL INAAINASFV YRHDGTDVKR RYFYQYVETG FTILFNIECV VKILCYGFRS
FFKRPIFKFE LILCIGSTLN VIPYFYDRNY FTIFQGFRLL RLIKASPILE DFVYKIFSPG
KKLGGLVIFT ITFVVICTAI SLQLFCSVPK LVYFQTFPKA FMAMFQIITQ EGWTDFVVEV
LRMIDDNMVP FVAIYFVAYH LFVTLIVLSL FVAVILDNLE MDEELKRVKQ LKAREATTTM
RTTLPWRLRV FEKFPARPAM VELKRLDSDF PLPKVRDSFT HQFATDDSEN DAEDSTEVVI
PKAVMRSVPL LRHPRKAKPI VRHVGPISLK ASISTIVEES NRNRSTDADT FSFATHLSRV
PTRLWRKEAQ RSRNKATPTL ARAKQILLEK MTENGDISRH SDTAPNKTQK HGEIDIRALQ
QKRHMAEVKR NRIEEDLREN HLLFDRPLFF IGRDSNLRRF CKNIVYAKYE AEIEGNGTGK
PARRYKELHT LVGLMTYLDW TMVIVTSLSC ISMLFESPWP TTGENLVFNN FYLQITDYLF
VLFMTFELVV KILANGMFFT PKAVVRDFGG VMTMFIYITS VVFLLHMPKH VEINSFNQLL
LIFRAMRPLR IYTLVPHIRR VVVELFRGFK EILLVTILLV VVMFIFASVG VQIVGGKLAA
CNDPSIKHRA NCTGVFWQKI FVTRLDVYGK NDDDLHPSIL VPRVWTNPRN FNFDHVGNGM
LALFETLSYK GWNVIRDIVW QRVGPWAVVF IHIYVFIGCM IGLTLFVGVV IANYTENRGT
ALLTVDQRRW HDLKARLKMA QPLHVPPKPS ESAKLRTRLY ELSMSRLFGQ IFAALVVINS
ATLCIPWNVE EEAERRDNDE EYKLFFATAL SAIINILFAV ECLLKMIAFT VTGFWQSRRN
RIDLLITALG LFWVVLHFFI ALPAEKLSKE AKLKKFTYTF GYMIVILRFF TIAGRNTTLK
MLMLTVVMSM FRSFFIITAM FLFVLFYAYT GVILFGMVKY GQAVSKHVNF RTGSEAMVVL
FRSITGEDWN DIMHDCMASP PLCYWSEGAS YWETDCGNYY GAIIYFCSFY VIITYIVRNL
LVAIIMENFS LFYSSEEDAL LSYADIRNFQ TVWNMVDVEQ KRTIPVRRVK FLLRLLRERL
EVDPNKDRLL FKHMCYEMER LHNGDDVSFH DVLYMLSYRS VDIRKSLQLE ELLQREEVEY
IIEEEVAKQT IRTWLEVCLK RMRTPSQKGS VSGPTMTRGA TAQSTVVSGG STFVVNSPPV
RPLNIQLQLE TPAVVSNKVD VTEPNVGPDE SSGDVEEVIT ERKKKKSTGG RRSSIPELMS
SSLFQEAAKK FMLGGGHKKS VCAFPGKASE TEIPQKQGTI SRIAAAARLT SQKVESRIAQ
HKTSYQPPSE LSEVKEFGEE SGGTSPIVDF IEQRRSSVPE TSRPIITQLG LDAVRVGSPP
RSPASFHLAM IDDSLQKDRI KDVKLWWKIV DVD
//
