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Database: UniProt
Entry: A0A0B2VDR6_TOXCA
LinkDB: A0A0B2VDR6_TOXCA
Original site: A0A0B2VDR6_TOXCA 
ID   A0A0B2VDR6_TOXCA        Unreviewed;      1833 AA.
AC   A0A0B2VDR6;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   28-FEB-2018, entry version 16.
DE   SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:KHN81661.1};
DE   Flags: Fragment;
GN   Name=NALCN {ECO:0000313|EMBL:KHN81661.1};
GN   ORFNames=Tcan_03468 {ECO:0000313|EMBL:KHN81661.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Ascaridida;
OC   Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN81661.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN81661.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN81661.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J.,
RA   Yang Y., Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W.,
RA   Jex A.R., Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHN81661.1}.
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DR   EMBL; JPKZ01001479; KHN81661.1; -; Genomic_DNA.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031036};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     12     32       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     80     98       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    234    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    272    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    393    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    483    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    548    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    895    916       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    928    947       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    992   1014       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1106   1132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1187   1209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1224   1244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1264   1284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1296   1313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1334   1358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1419   1437       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       17    305       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      359    581       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      856   1136       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1187   1456       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      776    796       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KHN81661.1}.
SQ   SEQUENCE   1833 AA;  211135 MW;  4CAA640D9F1F21BC CRC64;
     ADFLQSELAE NALKVACVIS LVTVCVHTPV TLQYFWPLSY IIFIMDFIST IILSAEAIIR
     LNAYGMFARN ESYFRDRWSQ FDFFLLIFHW LSLLLHAYER ITKLFPGMGL VYYEWYGVVR
     CVRPLIIIRL IRLVLKFKLP KNRIQQLLKR SSQQVQNVTT FFVFFMALYA ILGIQVFGRM
     DYHCILKDAD PRNITIADLA IPDTMCSMKG EGGYECPDNM VCEKIKMTAK EEGFYGMFNN
     FGASVFTVYL AASEEGWVYV LYDCMDSLPS YWAFLYFVTL IFFLAWLVKN VFIAVITETF
     AEIRVQFSEM WQKNEVTFDD GLKQRLEATE EGWKLVKFDS EKSKKTDGPF GLQRILRSTA
     FQCFITGIVL INAAINASFV YRHDGTDVKR RYFYQYVETG FTILFNIECV VKILCYGFRS
     FFKRPIFKFE LILCIGSTLN VIPYFYDRNY FTIFQGFRLL RLIKASPILE DFVYKIFSPG
     KKLGGLVIFT ITFVVICTAI SLQLFCSVPK LVYFQTFPKA FMAMFQIITQ EGWTDFVVEV
     LRMIDDNMVP FVAIYFVAYH LFVTLIVLSL FVAVILDNLE MDEELKRVKQ LKAREATTTM
     RTTLPWRLRV FEKFPARPAM VELKRLDSDF PLPKVRDSFT HQFATDDSEN DAEDSTEVVI
     PKAVMRSVPL LRHPRKAKPI VRHVGPISLK ASISTIVEES NRNRSTDADT FSFATHLSRV
     PTRLWRKEAQ RSRNKATPTL ARAKQILLEK MTENGDISRH SDTAPNKTQK HGEIDIRALQ
     QKRHMAEVKR NRIEEDLREN HLLFDRPLFF IGRDSNLRRF CKNIVYAKYE AEIEGNGTGK
     PARRYKELHT LVGLMTYLDW TMVIVTSLSC ISMLFESPWP TTGENLVFNN FYLQITDYLF
     VLFMTFELVV KILANGMFFT PKAVVRDFGG VMTMFIYITS VVFLLHMPKH VEINSFNQLL
     LIFRAMRPLR IYTLVPHIRR VVVELFRGFK EILLVTILLV VVMFIFASVG VQIVGGKLAA
     CNDPSIKHRA NCTGVFWQKI FVTRLDVYGK NDDDLHPSIL VPRVWTNPRN FNFDHVGNGM
     LALFETLSYK GWNVIRDIVW QRVGPWAVVF IHIYVFIGCM IGLTLFVGVV IANYTENRGT
     ALLTVDQRRW HDLKARLKMA QPLHVPPKPS ESAKLRTRLY ELSMSRLFGQ IFAALVVINS
     ATLCIPWNVE EEAERRDNDE EYKLFFATAL SAIINILFAV ECLLKMIAFT VTGFWQSRRN
     RIDLLITALG LFWVVLHFFI ALPAEKLSKE AKLKKFTYTF GYMIVILRFF TIAGRNTTLK
     MLMLTVVMSM FRSFFIITAM FLFVLFYAYT GVILFGMVKY GQAVSKHVNF RTGSEAMVVL
     FRSITGEDWN DIMHDCMASP PLCYWSEGAS YWETDCGNYY GAIIYFCSFY VIITYIVRNL
     LVAIIMENFS LFYSSEEDAL LSYADIRNFQ TVWNMVDVEQ KRTIPVRRVK FLLRLLRERL
     EVDPNKDRLL FKHMCYEMER LHNGDDVSFH DVLYMLSYRS VDIRKSLQLE ELLQREEVEY
     IIEEEVAKQT IRTWLEVCLK RMRTPSQKGS VSGPTMTRGA TAQSTVVSGG STFVVNSPPV
     RPLNIQLQLE TPAVVSNKVD VTEPNVGPDE SSGDVEEVIT ERKKKKSTGG RRSSIPELMS
     SSLFQEAAKK FMLGGGHKKS VCAFPGKASE TEIPQKQGTI SRIAAAARLT SQKVESRIAQ
     HKTSYQPPSE LSEVKEFGEE SGGTSPIVDF IEQRRSSVPE TSRPIITQLG LDAVRVGSPP
     RSPASFHLAM IDDSLQKDRI KDVKLWWKIV DVD
//
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