ID   A0A0B2VN57_TOXCA        Unreviewed;       343 AA.
AC   A0A0B2VN57;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Histone deacetylase 11 {ECO:0000313|EMBL:KHN83003.1, ECO:0000313|WBParaSite:TCNE_0001406901-mRNA-1};
GN   Name=Hdac11 {ECO:0000313|EMBL:KHN83003.1};
GN   ORFNames=Tcan_06456 {ECO:0000313|EMBL:KHN83003.1}, TCNE_LOCUS14069
GN   {ECO:0000313|EMBL:VDM45390.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN83003.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN83003.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN83003.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:TCNE_0001406901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDM45390.1, ECO:0000313|Proteomes:UP000267007}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR   EMBL; JPKZ01001277; KHN83003.1; -; Genomic_DNA.
DR   EMBL; UYWY01022046; VDM45390.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VN57; -.
DR   STRING; 6265.A0A0B2VN57; -.
DR   WBParaSite; TCNE_0001406901-mRNA-1; TCNE_0001406901-mRNA-1; TCNE_0001406901.
DR   OMA; GTHHAHY; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   Proteomes; UP000050794; Unplaced.
DR   Proteomes; UP000267007; Unassembled WGS sequence.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR   CDD; cd09993; HDAC_classIV; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR044150; HDAC_classIV.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN          47..328
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   343 AA;  38606 MW;  0D3152326FDA4CF6 CRC64;
     MDSLKHDREK LAYVTETKLY SGIRADQWPI VYHPLYNISF FGVEKLHPFD SSKWRRVHNE
     LIESGMLSEE QFVQASEASE HDLRVVHTGC YLASLHCPCR VARLVEVAIV AFLPSFIIDR
     YLLKPFRYHT GGSILAARLA LERNWAINLG GGFHHACRSR GGGFCVYADI SLALNFLFLK
     RLISRAMIVD LDAHQGNGHE HDFAGDNRVY IFDMFNYQIY PSDFVAKNAI SRSVPLRSGT
     GDAEYLRQLS KNLSAALGEF SADIIIYNAG TDCLEGDSLG LLSLTANGII RRDEIVFELA
     EQCHIPIVML MSGGYMPNNY DVIARSILNL HQKRLISLPS TSF
//