GenomeNet

Database: UniProt
Entry: A0A0B2VRL5_TOXCA
LinkDB: A0A0B2VRL5_TOXCA
Original site: A0A0B2VRL5_TOXCA 
ID   A0A0B2VRL5_TOXCA        Unreviewed;       894 AA.
AC   A0A0B2VRL5;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   15-FEB-2017, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=unc-32 {ECO:0000313|EMBL:KHN84248.1};
GN   ORFNames=Tcan_05632 {ECO:0000313|EMBL:KHN84248.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Ascaridida;
OC   Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN84248.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN84248.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN84248.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J.,
RA   Yang Y., Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W.,
RA   Jex A.R., Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHN84248.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JPKZ01001028; KHN84248.1; -; Genomic_DNA.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031036};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    450    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    678    697       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    834    858       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   894 AA;  102749 MW;  DFE96CB0FF2538FC CRC64;
     MGSLYRSEQM RFCQMIVQKD AAFACVAELG KHPYVQFKDL NADVNPFQRM FVRDIRRFDE
     LERKLRFIDT QIRKDNIEIV DECKDEVYEV MPPHELNQLE ATLVDLERDV INMNESDLLL
     KRNFLELKEW EAILEKADQF FQGGISDVAM QEIEAVEEEE IGFPLRADKE PMGFSTGVIN
     RERVNAFERI LWRACRRTAF VRTAEIEEEL IDPDNGEKMS KSVFVVFYKG DRLRTIIEKV
     CEGFKAKLYN TCPKNSKDRH AAARDVRARI SDLSTVMGQT HEHRYKVLQA ASSNLREWQK
     QVRMQKSVYH TLNLFTFDSI GKFFVAECWV PLDDMQNVRV ALERGVEANG ISVKPVLNLL
     ETAEEPPTYN KTNKFTAVFQ GIVDSYGIAS YLEVNPAPYT IITFPFIFAC MFGDFGHGLI
     MFFAGLYFVL RENVLIARNI KDEIFNMFFG GRYIILLMGI FSVHAGILYN DIFAKSFNIF
     GSSWRNPFPQ KELESWYNQS VLTQKEVLIE LPPIPSYLHS NGPYPFGVDP VWSLSENKLN
     FLNSMKMKLS VIIGISQMTF GVLLSLMNYM FFKSKIDILT VFIPQLLFMF CIFIYLCIEI
     IVKWTFFWVD ETYIFGRLYP GSHCAPSLLI GLINMFMFKE REAGFVNMSR IVRKEGQHII
     YAEYPNCYLG QWYPAQSIVE AVLVVVAVIC VPIMLFGKPV YLLSQQKKAK QAISDKMVVR
     VSMQNEETEI TSNGQGQGQS QGNGHIEKDQ EKSAVDESDA QAHHEEGFGD IMVHQAIHTI
     EYVLGCVSHT ASYLRLWALS LAHAQLSEVL WHMVLVQAFA LSGAAGYFAA YFIFFAFGVL
     TISILVLMEG LSAFLHALRL HWVEFQSKFY LGLGYQFVPF YFKDVLERAT AAEN
//
DBGET integrated database retrieval system