ID A0A0B2VZI4_TOXCA Unreviewed; 392 AA.
AC A0A0B2VZI4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tumor susceptibility transcribed protein {ECO:0000313|EMBL:KHN86380.1};
GN Name=Tsg101 {ECO:0000313|EMBL:KHN86380.1};
GN ORFNames=Tcan_10621 {ECO:0000313|EMBL:KHN86380.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN86380.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN86380.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN86380.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN86380.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPKZ01000628; KHN86380.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VZI4; -.
DR STRING; 6265.A0A0B2VZI4; -.
DR OMA; GTVYKFP; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..146
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 326..392
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT COILED 272..299
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 392 AA; 43910 MW; D5C63F08EC879E8B CRC64;
MSNASQVVAV LKRTKAKYVE SAKTDIITAL NFFHDLSPDA ENFTFPDGTR NLTFRLKGTI
PVLYKGTTYN IPVALYLWDT HPYYAPICYV CPTPNMMVKE SKTVDKQGRI YLPYLTDWRH
PGYDLIGLLQ VMALTFRESC PVFAKPSNST QRLASAGGSS TPQSQPAYTP YPTSVSAGMP
PYPMSSPQTG QYPVYQPPYP NAFPGIPVAH PQPPHTSPVT AAVGTIQPEH LKASILSAVE
DKIKQRLREK LGTVHAELAS IRQTHSELRA GQQKLKNICD ELASEQKQME ESLLIYQEKK
AELTSILSSH TEDMSVDIDS LIDACTPLHK QLLRCYVHDC AIDDTIYFLG QALKQGRMTL
PNYLKEVRQL SRKQFIYRAT LQKCRLKAKL PS
//
