ID A0A0B2VZK0_TOXCA Unreviewed; 1438 AA.
AC A0A0B2VZK0;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Location of vulva defective 1 {ECO:0000313|EMBL:KHN88981.1};
GN Name=lov-1 {ECO:0000313|EMBL:KHN88981.1};
GN ORFNames=Tcan_12899 {ECO:0000313|EMBL:KHN88981.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN88981.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN88981.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN88981.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN88981.1}.
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DR EMBL; JPKZ01000136; KHN88981.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2VZK0; -.
DR OMA; SSTEHIM; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 694..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1172..1192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1226..1245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1265..1288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1326..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 526..647
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 1438 AA; 162708 MW; 56AE3D898A394F43 CRC64;
MRQSSTEHIM SVYDMGINQR ITLKGGNIIR NQTDGFVITG FTMSSEGISE LGAPASKPQS
LLDADSQQKV AGILNSIDGY LQKSGSDLTN DQFNEVVDNA MSVLGGMIKS GNEALRNPLR
RDQDTALNHD LVNYDQIYLG IPLDPGSITY IDEYSQDEWA ISAAQVKQKT LCEQMVSTAS
NLMSTITNTL VQRESGGGLS PVSVQKEVCV CAKFRRESAI SIPETLVGLS RIEYPPSLRL
LNIQSIPETQ MIQSDFICYE ENPYTYVFNY PPLITSGAAM ATLKTYGGQV IPVRNALWPI
AITGTLSTAV DMPTEIYGGD FQNYQVLSIR SFFTMEWNVS LFIEFKKGLG SVNGGDIWIF
VSFQRLPGPL PDDHDWRFLV EDERVTNHFI VDSADMVNMT GTFFIGVGST IPADLYTNET
KAVKYTYNGS APLYFAKELP FDYSIRVFDK GCYYFADNNV GFNNYGQTVG EYVGNELVRC
YTNHLTPFSV SIHNPHISEF LAYVYLENNQ PGRIRYMKDN MYHADYKYLV AVETGYRMFA
TTDSKVLMNV IGDKGMEVAR ELYGDEEMGK QFRWGTTDRF LMTTVWPLGA LQTIRIWTDE
SGQGHRQSWY CSRIIFKDLQ TNEIFEFRVN KWFGSQTYDG KTQRLVHVTK KRNCNVLVDA
LSFHSLADHI TYWNMFTGGG LLTRLRFDRV ERVLNVYLAV LLAMLTNILV AANESYEKVN
LASISILGYY FSWKDVVLGF VFSWVCIPTS ILIPYIHSFI PVMHKASEKG ENFLKMSKHD
MRGRLRWWHR LAHLIKYIEL AIAIAIAICI VQLAFGYYVE QTMAFSRRFI ITLLFWILFT
EPLKAFICSL FCTVACKNYR LIRKYELPEI GERISAIDVV PKKEFAGMLE HNVVKLQCVS
TTRDRRMRDE QLFVTTREVV FVFVSVAICL GFAFSSQDTA AYYYQVEVGT PFLGLDKDKS
NANGVSRMMG YGIVRQVRSI TNRNCGVVKQ FEGFFNACDG YTRRKLEDTT AAYNVGWNEV
IDVSKAKPQY IYHSEEALQG RPFYGDHDSY SGGGYIQTLN GSSEDLRAAF TKLENESWIN
EGTRAVFIEF SVYNAQTNHF SVIQLVLEIP PFGTVFPTAS IQIVRLLKNV GGEHVNTATL
FEVLYILLCI VLALKELFVL ISCSPIEYFS SFWNYVDLTI AACAIASLIS YVFRQIGINQ
AIAMFMAMNG NGYIRLDRQR DLQLIFLALL SAVVFLTCMK MINILRFNRR IGLFTQTLSH
SAPTMVIFGA VFCIVSLAFD SALFVILASR LQLYRNLTTV AKTTIISLLG KLSATDIAAI
SPFGAAVYII FILAGKIGLL NFFVMLVMTE FETLRRDPKN QSNDYEALDH IASKALKVCK
QYRRHHLPNL GFPDTLHTSL ACDRLEAKVE LLAHSLSALC WHVRFTYGID EETRKKIA
//
