GenomeNet

Database: UniProt
Entry: A0A0B2W556_TOXCA
LinkDB: A0A0B2W556_TOXCA
Original site: A0A0B2W556_TOXCA 
ID   A0A0B2W556_TOXCA        Unreviewed;       399 AA.
AC   A0A0B2W556;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   08-NOV-2023, entry version 31.
DE   SubName: Full=Aspartic protease 6 {ECO:0000313|EMBL:KHN88410.1};
GN   Name=asp-6 {ECO:0000313|EMBL:KHN88410.1};
GN   ORFNames=Tcan_07400 {ECO:0000313|EMBL:KHN88410.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN88410.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN88410.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN88410.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN88410.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPKZ01000233; KHN88410.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2W556; -.
DR   STRING; 6265.A0A0B2W556; -.
DR   OMA; DEEYIGN; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF44; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:KHN88410.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..399
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002077945"
FT   DOMAIN          77..394
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        96
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        109..114
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        320..354
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   399 AA;  44142 MW;  1A6DEFD6FF7D00C6 CRC64;
     MKLFLIQLAF VTLTAAVVTR VPLLHIETRR IRLIREGKWE EHRRMKEELR SIRIKAGSSK
     PRVVSSQGVN DYDDLEYVGN ITIGTPPTQQ FNVVLDTGSS NLWIPDSTCT TSDCSLKHRY
     NANASSTHSI DGRQWRVIYG DGSNANGYLG TDVITLGGVG EAQLRIQSQT FGQATSMMGF
     RNDPVDGILG LGFTALADDF VEPPVINAIA QKLLDEPIFT VWMQAAGYQQ NVYGGQFTYG
     GLDPEHCGPV IAYQPLSMAS FWQYRMKAIG VGNYLNRKGW EVIADTGTSF IGGPAYVIDE
     IGAALGAKYD HYNQLYFVPC GSEDTLINIV LYVGEHKYEI EPRNYIVKMT TNKCAVGMFG
     YSSGGYGPTW ILGDPLIRQY CVIHDVGQQR IGFARSKTA
//
DBGET integrated database retrieval system