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Database: UniProt
Entry: A0A0B2WV78_9HYPO
LinkDB: A0A0B2WV78_9HYPO
Original site: A0A0B2WV78_9HYPO 
ID   A0A0B2WV78_9HYPO        Unreviewed;       862 AA.
AC   A0A0B2WV78;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   11-NOV-2015, entry version 7.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=MAM_04949 {ECO:0000313|EMBL:KHN97352.1};
OS   Metarhizium album ARSEF 1941.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHN97352.1, ECO:0000313|Proteomes:UP000030816};
RN   [1] {ECO:0000313|EMBL:KHN97352.1, ECO:0000313|Proteomes:UP000030816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHN97352.1,
RC   ECO:0000313|Proteomes:UP000030816};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and
RT   host adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHN97352.1}.
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DR   EMBL; AZHE01000011; KHN97352.1; -; Genomic_DNA.
DR   EnsemblFungi; KHN97352; KHN97352; MAM_04949.
DR   Proteomes; UP000030816; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030816};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030816};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    422    446       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    458    483       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    788    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
FT   COILED      279    306       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   862 AA;  98153 MW;  0C4E1A438234BDC1 CRC64;
     MAPKQDTPFR SADMSMVQLY VSNEIGREVV TALGELGLCQ FRDLNEDVSA FQRTFTQEIR
     RLDNVERQLR YFHAQMGKAG ISLRKLDLDT ERLASPSTSE IDELAERSQK LEQRIFALND
     SYETLKKREG DLTEWRWVLR EAGSFFDRAH GNVDEIRASV DNDDAPLLQD MEQHHSAPEV
     ERSFSGMNIG FVAGVITRDR VAAFERILWR TLRGNLYMNQ SEIPEPLIDP TNNESINKNV
     FVIFAHGKEI LAKIRKISES LGAEVYSVDE NSDLRRDQVH EVNNRLQDVQ NVLRNTQATL
     EAELNQISQS LSAWMILIAK EKAVYSTLNL FSYDRARRTL IAEAWCPTHD MPLIRSTLQD
     VTNRAGLSVP SIINEIRTNK TPPTYLKTNK FTEGFQTIVN AYGTATYQEV NPAIPVFVTF
     PFLFAVMFGD FGHAIIMLSA ALAMIYWEKS LKKVSFELFA MIFYGRYIAL VMAVFSVFTG
     LIYNDVFSKS MTLFPSAWEY EKPNGWQPGQ TIEAKLNDEG YRYPFGLDWA WHGTENTLLF
     SNSYKMKMSI ILGWAHMTYS LCFSYINAKH FRKPIDIWGN FVPGMIFFQS IFGYLVICIV
     YKWTVDWTNP DPAIGGQPPG LLNMLIYMFL RPGKLDVPLY KGQAAVQIML LLLAFAQVPI
     LLFLKPFYLR WEHNRARAKG YRGIGETSRV SALDGDDENQ GLVNGHGNSF DDDGEGVAMI
     SQNIDEEHGE FEFGEVMIHQ VIHTIEFCLN CVSHTASYLR LWALSLAHQQ LSIVLWDMTL
     GPTLKAPGVT GVVMIVVGFF LWFFLTIAIL VCMEGTSAML HSLRLAWVES FSKFAEFGGW
     PFAPFSFNTV LEDSEELKEF LG
//
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