ID A0A0B3BT73_9PSED Unreviewed; 310 AA.
AC A0A0B3BT73;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:KHO64251.1};
GN ORFNames=PT85_13560 {ECO:0000313|EMBL:KHO64251.1};
OS Pseudomonas flexibilis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=706570 {ECO:0000313|EMBL:KHO64251.1, ECO:0000313|Proteomes:UP000030980};
RN [1] {ECO:0000313|EMBL:KHO64251.1, ECO:0000313|Proteomes:UP000030980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 14085 {ECO:0000313|EMBL:KHO64251.1,
RC ECO:0000313|Proteomes:UP000030980};
RA Shin S.-K., Yi H.;
RT "Genome sequence of Pseudomonas tuomuerensis JCM 14085.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHO64251.1}.
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DR EMBL; JTAK01000005; KHO64251.1; -; Genomic_DNA.
DR RefSeq; WP_039606927.1; NZ_JTAK01000005.1.
DR AlphaFoldDB; A0A0B3BT73; -.
DR STRING; 706570.PT85_13560; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000030980; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000030980}.
FT DOMAIN 7..309
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 106..278
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 310 AA; 32847 MW; 98754E3066BB4412 CRC64;
MKPTLLLLSP LPASLNDRLA AHFDCHEQSQ LDEQSAIALA PVVRGIIATG ESILTREEIA
RWPALEIIAV LGVGYDGIDL GAAHDYNVRV THTPGLSTED IADFAMALLL CATRQLLSAD
RFVRQGGWTS SRYPTTRRVS GGRMGIVGLG RIGSALAVRA EAFGMSIAYT GRTQKTGVPY
RWYSDVQGLA ADVDFLVICA TGGPATQAMV NGAVLDALGP TGVLVNIARG TIVDEEALVR
ALREGKILAA GLDVFRDEPR VPAALLELPN VVLSPHMAST TEATVRAMAD LVFDNLAAHF
SGQPVLTPVV
//
