ID A0A0B3WMG2_9FIRM Unreviewed; 395 AA.
AC A0A0B3WMG2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 25-OCT-2017, entry version 16.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KHS55720.1};
GN ORFNames=QX51_17675 {ECO:0000313|EMBL:KHS55720.1};
OS Terrisporobacter othiniensis.
OC Bacteria; Firmicutes; Clostridia; Clostridiales;
OC Peptostreptococcaceae; Terrisporobacter.
OX NCBI_TaxID=1577792 {ECO:0000313|EMBL:KHS55720.1, ECO:0000313|Proteomes:UP000031189};
RN [1] {ECO:0000313|EMBL:KHS55720.1, ECO:0000313|Proteomes:UP000031189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=08-306576 {ECO:0000313|EMBL:KHS55720.1,
RC ECO:0000313|Proteomes:UP000031189};
RA Lund L.C., Sydenham T.V., Hogh S.V., Skov M.N., Kemp M.,
RA Justesen U.S.;
RT "Draft genome sequence of Terrisporobacter sp. 08-306576, isolated
RT from the blood culture of a bacteremia patient.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC Note=Divalent metal cations. Prefers magnesium or manganese.
CC {ECO:0000256|PIRSR:PIRSR000106-3};
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:KHS55720.1}.
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DR EMBL; JWHR01000151; KHS55720.1; -; Genomic_DNA.
DR RefSeq; WP_039681225.1; NZ_JWHR01000151.1.
DR EnsemblBacteria; KHS55720; KHS55720; QX51_17675.
DR Proteomes; UP000031189; Unassembled WGS sequence.
DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.50.10380; -; 1.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PIRSF; PIRSF000106; ME; 2.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000031189};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000031189}.
FT DOMAIN 18 151 malic. {ECO:0000259|SMART:SM01274}.
FT DOMAIN 163 386 Malic_M. {ECO:0000259|SMART:SM00919}.
FT ACT_SITE 39 39 Proton donor. {ECO:0000256|PIRSR:
FT PIRSR000106-1}.
FT ACT_SITE 94 94 Proton acceptor. {ECO:0000256|PIRSR:
FT PIRSR000106-1}.
FT METAL 136 136 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000106-3}.
FT METAL 137 137 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000106-3}.
FT METAL 162 162 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ SEQUENCE 395 AA; 42550 MW; F8289C082C4B2F6C CRC64;
MGNKNFAQLA LEMHENHGGK VSIQSKVEVK CKDDLSIAYT PGVAEPCLKI KENPEEVYKY
TCKSNMVAVV SDGTAVLGLG NIGAAASIPV MEGKSILFKE FGEVDAFPIC INTMDIDDIV
KTVKLLEPVF GGINLEDINS PRCIEIENRL KEELDIPVFH DDQHGTAIIV SAGILNAAKL
AGKKIEDLEI VINGAGSAGM AIAKMLINLN VKNVVLCDIN GAIHENSKDI NWAQKEMLKV
TNKNNEVGTL VDIIKNKDVF IGVSAPKMVT KEMVATMSDK AIVFAMANPT PEIFPDEAKA
GGAFIVGTGR SDFPNQVNNV LAFPGIFRGA LDVRAREINE EMKVAAAYAI ANVVSEDELT
PDYVLPDAFN KNVVKNVAKA VREAAIKTGV ARIEK
//
