GenomeNet

Database: UniProt
Entry: A0A0B4K7I8_DROME
LinkDB: A0A0B4K7I8_DROME
Original site: A0A0B4K7I8_DROME 
ID   A0A0B4K7I8_DROME        Unreviewed;      2608 AA.
AC   A0A0B4K7I8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 25.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=NaCP60E {ECO:0000313|EMBL:AFH08263.1,
GN   ECO:0000313|FlyBase:FBgn0085434};
GN   ORFNames=CG34405 {ECO:0000313|FlyBase:FBgn0085434}, Dmel_CG34405
GN   {ECO:0000313|EMBL:AFH08263.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AFH08263.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE013599; AFH08263.1; -; Genomic_DNA.
DR   RefSeq; NP_001246510.1; NM_001259581.2.
DR   UniGene; Dm.20002; -.
DR   PaxDb; A0A0B4K7I8; -.
DR   EnsemblMetazoa; FBtr0308347; FBpp0300666; FBgn0085434.
DR   GeneID; 37981; -.
DR   CTD; 37981; -.
DR   FlyBase; FBgn0085434; NaCP60E.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   GenomeRNAi; 37981; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   ExpressionAtlas; A0A0B4K7I8; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    152    170       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    190    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    245    265       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    373    399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    689    707       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    753    777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    797    828       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    886    911       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1755   1773       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1785   1806       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1812   1834       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1866   1892       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1984   2008       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2070   2090       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2096   2117       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2129   2147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2186   2214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2285   2309       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      125    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      688    918       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1751   2017       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2069   2319       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2325   2386       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2608 AA;  296753 MW;  C346CE60D3F69E86 CRC64;
     MSDDQATFND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
     FEPFPEHMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFY PWSPARRVCV
     YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
     LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
     QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRQVPTDW TNVSHTDWQI WVNDTDNWLY
     DEDELPVLCG NLTGARHCPF EYVCLCVGEN PNHGYTNFDN FMWSMLTTFQ LITLDYWENV
     YNMVLATCGP MSVSFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
     STFSFDPSVL NVKKLNKNNK KKIDSRKGVL LASYSKKKTR RKKTKGGKEG GTNGNGNGSN
     GDDNKSHSAT PSPGPSPRHS ATERPSALTM QAQKQYQQME QQHKLAKSGS GGSNNPMAPT
     PKGRISFQDS GMGVKNPNML YPSDYKGQLI ANSGQPSSNS SGVNRESSQD DSGVVDDHEE
     QDTTNDMGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
     CDRCVHWCTD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
     DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
     RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTPEKF
     DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
     MVLNLFLALL LNSFNSEELK SKKEEVGEES KLARSIERVR DLIRKKRQER KDRKERKFAE
     KFQQIVLDAQ QAHAQTLSHQ AAVGLERGDK PGVLAETKFH RLSYQESMNR PVSGSDFGFQ
     IPLHDGLHTI VDGLEYDDTG DLPEQIQLQA HPLPPTSDSM PPTYESAMMA TTGGSFSSVN
     GNGTCQNLTP FVQAERRLQH QISSGVSTQQ YDSREEATYT ESIELLGQYN STDTDPYAND
     QRSGCGSFNR GDSLQDNSSR RYGSEEHDEA FLKYQKSLLT RSPSYRKSLD RLSQSSGQSQ
     RSLLKSEEAE MRRHSSGQSL NSMSIEQDEL LSQQGNLREE LLNCDQKELF QFLQEEEELQ
     KGTKLRRISN VMRSRRPSSQ MGQPENETMV EHSEFDNIIQ SFEKELEEIK RSTTSLERKL
     SNLSEPSPAA DEATKAIMEH IAIITGASER SAADEVVLPL NPYDSYDLSS VPRRSQSVSA
     AAQRQSVKLK RRSLEKQRKI DEDFSISNEI RKICDQIHAP FVAMEAMAVA ATSASQAQPN
     QSPFLRRKVD PFTVQFDRFK RLSLIERVEE VPEEEKPIST LRIESEKMPR KFLHGPDQLR
     LDSLSLKSTN SYENLLIQKQ KLGMATPPAV PATPPTSLKS SIEPPTLAQI SSLKTTPPLA
     ALTEHQQHFH ATSIQAAPTP AHTHAHSQAH AHSMAGQRRR MEHPQSTLDK AASFQSARTE
     SHSSGAADAS SALALAMAQK TEQSQSTAPD ATQKPSAFTR LTEKPWHCLV SYVDDLTVGG
     RRNSQGAYND PMTFPSYGAT KAAKVPDDCF PQKCYDHFYF RCPWFMSCMD TQSAKHWTRV
     RTAVLTVVDT PAFEWFVLVL IFASSITLCF EDINLDKNKT LKRVLYWINF SFCLIFVVEM
     ILKWLALGFS KYFTSFWTIL DFIIVFVSVF SLLIEENENL KVLRSLRTLR ALRPLRAISR
     WQGMRIVVNA LMYAIPSIFN VLLVCLVFWL IFSIMGVQFF GGKFFKCVNE MGELLPITEV
     NDKWDCIEQN YTWINSKITF DHVGMGYLAL LQVATFEGWM EVMADAVDAR GVDLQPQREA
     NLYAYIYFVI FIVCGSFFTL NLFIGVIIDN FNMLKKKYEG GVLEMFLTES QKHYYTAMKK
     LGRKKPQKVI KRPINHFLAM FYDLSNSRRF EIAIFVLIFL NMLTMGIEHY DQPHAVFFIL
     EVSNAFFTTV FGLEAIVKIV GLRYHYFTVP WNVFDFLLVL ASIFGILMED IMIDLPISPT
     LLRVVRVFRI GRILRLIKAA KGIRKLLFAL VVSLPALFNI GALLGLITFI YAILGMSLFG
     NVKLQGALDD MVNFQTFGRS MQLLFRLMTS AGWNDVLESL MIQPPDCDPF IHGHTNGNCG
     HPLLAITYFT SFIIISYMIV INMYIAIILE NFNQAHQEEE IGIVEDDLEM FYIRWSKYDP
     HATQFIHFSQ LSDFIASLDP PLGISKPNNV ALVSFNLPIS KGNKIHCLDI LHALVKHVLG
     HVEETDNFKQ LQEQMDVKFK KQFPTRKELE IVSSTRIWKR QEKAAKTIQT GWKEYLRRKR
     EKERSNSGDS ATQTSSPGGW QSKLSALNFF HLQVSRRGTA CSSRASSRKS SRASDASDLS
     ELAGPWLNLP LMLVSGADEV VKDIKQQNDE LGKRRNEQHD QHHLKLRLHL RHGLLHRHRP
     SHWVWPSSHL RLRQRPTPGG GGWVGSIT
//
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