ID A0A0B4LFA9_DROME Unreviewed; 1725 AA.
AC A0A0B4LFA9;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Prosap, isoform C {ECO:0000313|EMBL:AHN56200.1};
GN Name=Prosap {ECO:0000313|EMBL:AHN56200.1,
GN ECO:0000313|FlyBase:FBgn0040752};
GN Synonyms=anon-WO0118547.149 {ECO:0000313|EMBL:AHN56200.1},
GN BcDNA:GH23107 {ECO:0000313|EMBL:AHN56200.1}, CG13354
GN {ECO:0000313|EMBL:AHN56200.1}, CG8122 {ECO:0000313|EMBL:AHN56200.1},
GN D-ProSAP {ECO:0000313|EMBL:AHN56200.1}, Dmel\CG30483
GN {ECO:0000313|EMBL:AHN56200.1}, ProSAP {ECO:0000313|EMBL:AHN56200.1},
GN prosap {ECO:0000313|EMBL:AHN56200.1}, Shank
GN {ECO:0000313|EMBL:AHN56200.1};
GN ORFNames=CG30483 {ECO:0000313|EMBL:AHN56200.1,
GN ECO:0000313|FlyBase:FBgn0040752}, Dmel_CG30483
GN {ECO:0000313|EMBL:AHN56200.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN56200.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE013599; AHN56200.1; -; Genomic_DNA.
DR RefSeq; NP_001286402.1; NM_001299473.1.
DR SMR; A0A0B4LFA9; -.
DR DNASU; 50225; -.
DR EnsemblMetazoa; FBtr0339763; FBpp0308810; FBgn0040752.
DR GeneID; 50225; -.
DR AGR; FB:FBgn0040752; -.
DR CTD; 50225; -.
DR FlyBase; FBgn0040752; Prosap.
DR VEuPathDB; VectorBase:FBgn0040752; -.
DR GeneTree; ENSGT00940000153561; -.
DR OrthoDB; 2247290at2759; -.
DR BioGRID-ORCS; 50225; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Prosap; fly.
DR GenomeRNAi; 50225; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0040752; Expressed in eye disc (Drosophila) and 22 other cell types or tissues.
DR ExpressionAtlas; A0A0B4LFA9; baseline and differential.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase.
DR GO; GO:0014069; C:postsynaptic density; IDA:FlyBase.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central.
DR GO; GO:0030160; F:synaptic receptor adaptor activity; ISS:FlyBase.
DR GO; GO:0097107; P:postsynaptic density assembly; ISS:FlyBase.
DR GO; GO:2000050; P:regulation of non-canonical Wnt signaling pathway; IMP:FlyBase.
DR GO; GO:1990255; P:subsynaptic reticulum organization; IMP:FlyBase.
DR GO; GO:0051124; P:synaptic assembly at neuromuscular junction; IMP:FlyBase.
DR CDD; cd17091; FERM_F0_SHANK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135:SF28; LD13733P; 1.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 191..223
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 258..290
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 291..323
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 382..443
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 562..655
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 456..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1461..1517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1644..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1725 AA; 183715 MW; 2E237F81A9C6BCBA CRC64;
MSGSGAFDDE PPPEPRDGWL LVRIHVPELN VYKCLQFPSE RLVWDVKQQV LASLPKELKE
SFNYGLFAPP ANGKAGKFLD EERRLGDYPF NGPVGYLELK YKRRVYKMLT LDERQLKALH
TRANLRRFLE CINGGHVEKI AKMCAKGLDP NFHCSESGDT PLTVATGAKK PNKLLIALVN
GGALLDYRTK DGSTALHRAV EHDSLEAVST LLELGASPNY RDGRGITPLY ISITRKCEAK
ITESLLHDHA TLGIQDSQGW NEVHQACRHG LVQHLEHLLF YGADMDGRNA SGNSPLHVCA
VNNQEACARM LLFRGAQRGA QNFANQTPYQ VAVIAGNLEL AEIIENYKSE DIDKSLGDTS
DIISDSSGVG TNSDSAACSI GHPSTTVVCM EPYAGNTVGH IRLQPGDVIE VVGSTDCGLL
EGYVRGTNQS GFFPADCVQE VSLRQKHITN VMTASTGMAP QQQQQQHLQQ APAGSSAASY
QGSPQLSLGG HSGSSSTLLQ QPHQSPSLSV ASNGSCQQPL ESNEGGASGN GINNRNNNHS
VGQYSSATAP RIKKSAYNAP RSVVLHRAKR GFGFILRGAK ASSQLMQLRP SERFPALQYL
DDVDPGGVAD MAGLRPGDFL LTINGEDVTS ASHEQVVEMI RSAGALVNLT VVSPQFPHQM
QASAQYLPSG ARAGSHHLNS GPSTPQSSHR QCATLPRKMT GPGGSGPGSS SGGSVRMAPM
PPRRDPKTTL SVGRARAKSM VAGLENGGEK EDDLPHTKSN SVESIATPTP TGIQTGPGTP
VQLRTASIKA RPTSSRITAA ELEELFQRQQ GEGSAANASR YATMMTSSRF QSGTDSGAAT
PPASNGSPMR SGPLVYGSVA EMKRKTARSK HGSGTLRGKP VATPTVGPGG AGGGRDLKRF
HSTPDLHGPQ LHGSASSIWQ ASGKGHHSQD DVATLHASLQ RLNSNQGELK LGGLGAGSAT
GAGGAVLPPP NHPPPPPPVG QVVKVETRSS VSEYESTISL QQKLKKRTEN DAVTSAAIDG
VQSSFNPSAN AKIYASPQEL RNVMAWKLRQ AQEKPSQETS AGSQQPVSQY AAPTQMRPAQ
QQQQAQQPPT ALASHYAAPQ VQVQQVQQVQ QSPQQSAPQS PPAPPLPQAA PVPAQNGNGN
GSTSGAGSAP PIPEPDYSCS ESDGEDENSI LVARNTKLNE KIALFDVPET SGNSQASGSS
SNSGSASISH SLSVEEIQRI RSNLKTSKSS PNGFAKKPEE EKPQQEQQQS HQQPQQLLQP
GEDECDNSSS GVSSEQEQLA LAAGVTLPGG GKPTDTIKKK PSVTIVEEPK TIPDQPSSNT
SHTTKPMAKT TISIGGGGSA VPTATLTVKQ LVQQQHAPVI QQQQQQLGSK QPVTAASTNK
FTQQSNINSN VMSPQVLGRI PSHHHQQQSS NPNQKLIATQ QQILQQQQQQ LAHQQHLQQI
LKAKAAAAGG ASNTAVLVAK HQQKLHKGTS SGHESEMETR SDLEDDDGDL SPSPPAKAFQ
RHNSLTRKQA AAIAMQRGAT RTTAVSLMQL PPPLEADSDG EPSQLTLQRQ QSHHPSQTHP
HPHQLQQQLQ LQQQQQQQQQ QQQPMAAHIV GMLPSGQLVA VASGAVAGVP GVGATAVQQG
NNNLQQLCTD NLVLAPPPQF CDCNDAKHAP QPHLPTSQYH PQQQQQQQHQ QQQQQQQQLQ
QQLQQQQMLQ MHQRLSGGAG AGAVGTLGRV RIVGAMPKAN HHRLH
//
