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Database: UniProt
Entry: A0A0B4LFE7_DROME
LinkDB: A0A0B4LFE7_DROME
Original site: A0A0B4LFE7_DROME 
ID   A0A0B4LFE7_DROME        Unreviewed;      1953 AA.
AC   A0A0B4LFE7;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 24.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M ortholog, isoform I {ECO:0000313|EMBL:AHN56245.1};
GN   Name=Trpm {ECO:0000313|EMBL:AHN56245.1,
GN   ECO:0000313|FlyBase:FBgn0265194};
GN   ORFNames=CG44240 {ECO:0000313|FlyBase:FBgn0265194}, Dmel_CG44240
GN   {ECO:0000313|EMBL:AHN56245.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AHN56245.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; AE013599; AHN56245.1; -; Genomic_DNA.
DR   RefSeq; NP_001286447.1; NM_001299518.1.
DR   UniGene; Dm.2244; -.
DR   PaxDb; A0A0B4LFE7; -.
DR   EnsemblMetazoa; FBtr0339081; FBpp0308227; FBgn0265194.
DR   GeneID; 36694; -.
DR   CTD; 36694; -.
DR   FlyBase; FBgn0265194; Trpm.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   GenomeRNAi; 36694; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   ExpressionAtlas; A0A0B4LFE7; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR032415; TRPM_tetra.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AHN56245.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    858    878       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    925    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    992   1009       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1072   1092       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      864   1097       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1188   1243       TRPM_tetra. {ECO:0000259|Pfam:PF16519}.
SQ   SEQUENCE   1953 AA;  217985 MW;  CC8CA7E83552C0F8 CRC64;
     MLKQKRLAKQ KPKAKPHQPR SWIETNFQKR ECIKFIPCPK DDTKCCCGQA QITHQTIPGI
     ESGSPGDLWL PTKHTRPQPT DAYGTIEFQG GAHPTKAQYV RLSFDTRPEL LVQLFTKEWN
     LELPKLLITV QGGKANFDLQ AKLKKEIRKG LLKAAKTTGA WIFTGGTNTG VTKQVGDALL
     LEGQQRTGRV VSIGIAPWGI VERNHELLGH NREVPCHSIS SPRSKLAVLN NRHAYFLLVD
     NGTQAKYGAE LILRRKLEKF ISNLKLHPFT HSSTPVVCLV IEGGTNTIRA VLEYVTDSPP
     VPVVVCDGSG RAADLLAFVH KYASDGEEQP VLESMRDYLI GTIQKTFEVG LDQSEKLYQE
     LLQCTRNKNL ITVFRIQEKP EGEAQELDQT ILTALFKSQH LSPPEQLSLA LTWNRVDIAR
     SEIFVYGQEW PNGALDEAMM QALEHDRIDF VKLLLENGVS MKKFLTIPRL EELYNTKHGP
     ANTLGYILRD VRPHIPKGYI YTLHDIGLVI NKLMGGAYRS YYTRRKFRPI YAKVMNSYAN
     ACRKSSTYQY QRYAGANSLS LVTGLLPFTS EMALFEFPFN ELLIWAVLTK RQQMALLMWT
     HGEEALAKSL VSCKLYKAMA HEAAEDDLDT EIYEELRSYA KEFESKGNKL LDFSYRQDAE
     KAQRLLTCEL HSWSNQSCLS LAVAANHRAL LAHPCSQVIL ADLWMGGLRT RKNTNFKVIL
     GLAMPFYIRQ LDFKSKEELQ QMPQTEEEHL ENQNLDNDDS DRSQPDAESA LLKAKRSISL
     RYRMGAGANN RDKALLADTY SVRDTKVHEN GKVSLTDSDT AQFREFFNLS EYNEVKQHQP
     LRLKKKFYEF YTAPITKFWA DSIAYMFFLI MFSFTVLVKM EQMPRWQEWY SIAYITTLGF
     EKVREIISSE PVAITHKFSV WAWNMWNPCD GAAIILFVIG LAFRFRENTM DIGRVIYCVD
     SIYWYLRILN ILGVNKYLGP LVTMMGKMVK NMIYFVVLLA VVLMSFGVSR QAILYPNKQP
     TWSLIKEVTF QPYFMLYGEV FAGDIDPPCG EDPSQPGCVT GHWVTPITMS MYLLIANILL
     INLLIAVFNN IFNEVNSVSH QVWMFQRFTV VMEYQQKPVL PPPFIALCHF YSLLKYCVRK
     AKGLEVQRDN GLKLFLEKDD LERLYDFEEE CVEGFFHEQE IILNQSTDER VKNTTERVET
     MSQKIEDINQ KENIQTATVQ NIEFRLRKME ESSEQILSHL AVIHRFMSTH TAGADDLRGS
     TINIPGEMQR MRTISISDTE GGSGPGGNGG GGGGGGAIVP LGLGAGLNLN SLQVTTRRRF
     NRSLTEVRPD AYIFDEGTHF EVVPLPEEPD EVVKSREALN EQVVRKASMQ SEADSDIYIP
     VSQRPSTCET VKRTPYVTVR QDTGASTESK DTLTPMGNND DDQTLVGGDN SDDATPDINF
     EAARHRALRQ RTVSLCRRNS ETYSLTGADI NRSHISLNQL ASLSRRQMSL TQSEPDSDKD
     APIAQGSAHP GKSVLHAKPS RNILLKLHSE YTSITDELES VCHMIASPTV SLPSNKASLD
     RPKTEMSRAE AAALLEKKHL KECEENDYMI LEGLIESRGS IDASAQGFEI GVSIDYSHRY
     PLRRETAVEL SPSKPSVDGD LMGGGEGGGA GGGDSSDTSG AGSCGAMVGI SSGFQLKNER
     PWQRNSSMEQ QTYPSPLVPT RATSDFLNPP YEGRLFKKSS ESLQKNSSTE TDYSAHPYRF
     IKQSSNETNT SLTGSYNVDT PSLTAEPSLD AGDSHSATGI SISVGAVGGT ATARYQPIRT
     ASVGAADGRR LREESSSSLD LSSSGPVTMQ AAPAPPVRPM LLKKQFSVDQ GKPSQTAAEA
     VPQTPEAAQA GQAKLISTLK PQPFASKLGM NVLKESSSST DESVGSSAKS SNPALSIPQI
     STHLVQDEIA KLSSNIKSST ESEKDPPFNE TMC
//
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