ID A0A0B4LFH9_DROME Unreviewed; 1072 AA.
AC A0A0B4LFH9;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=unc-5 {ECO:0000313|EMBL:AHN56248.1,
GN ECO:0000313|FlyBase:FBgn0034013};
GN Synonyms=AAF7419 {ECO:0000313|EMBL:AHN56248.1}, CG8168
GN {ECO:0000313|EMBL:AHN56248.1}, CT20824 {ECO:0000313|EMBL:AHN56248.1},
GN Dmel\CG8166 {ECO:0000313|EMBL:AHN56248.1}, Dunc5
GN {ECO:0000313|EMBL:AHN56248.1}, dUnc5 {ECO:0000313|EMBL:AHN56248.1},
GN UNC-5 {ECO:0000313|EMBL:AHN56248.1}, Unc-5
GN {ECO:0000313|EMBL:AHN56248.1}, UNC5 {ECO:0000313|EMBL:AHN56248.1},
GN Unc5 {ECO:0000313|EMBL:AHN56248.1}, unc5
GN {ECO:0000313|EMBL:AHN56248.1}, UNC5D {ECO:0000313|EMBL:AHN56248.1},
GN Unc5d {ECO:0000313|EMBL:AHN56248.1};
GN ORFNames=CG8166 {ECO:0000313|EMBL:AHN56248.1,
GN ECO:0000313|FlyBase:FBgn0034013}, Dmel_CG8166
GN {ECO:0000313|EMBL:AHN56248.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN56248.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; AE013599; AHN56248.1; -; Genomic_DNA.
DR RefSeq; NP_001286450.1; NM_001299521.1.
DR RefSeq; NP_611033.2; NM_137189.3.
DR AlphaFoldDB; A0A0B4LFH9; -.
DR SMR; A0A0B4LFH9; -.
DR DNASU; 36703; -.
DR EnsemblMetazoa; FBtr0087382; FBpp0086514; FBgn0034013.
DR EnsemblMetazoa; FBtr0339998; FBpp0309017; FBgn0034013.
DR GeneID; 36703; -.
DR KEGG; dme:Dmel_CG8166; -.
DR AGR; FB:FBgn0034013; -.
DR CTD; 36703; -.
DR FlyBase; FBgn0034013; unc-5.
DR VEuPathDB; VectorBase:FBgn0034013; -.
DR OMA; CMQNKRF; -.
DR OrthoDB; 2971005at2759; -.
DR PhylomeDB; A0A0B4LFH9; -.
DR BioGRID-ORCS; 36703; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36703; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034013; Expressed in wing disc and 29 other cell types or tissues.
DR ExpressionAtlas; A0A0B4LFH9; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 31..1072
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025096624"
FT DOMAIN 232..314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 654..802
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 994..1067
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 77..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 116418 MW; A0A6B5A96B10138F CRC64;
MAVINKAGNV IALLLVKLQL ILLFTLSVSG ELPQLDYGSL SASLEEDAID PLTAMAPFAN
SLVTEESAQH KNNAELLGNS SEDENVRPQQ GSSSSGLGSS GAAGGSGILL EEFNSGKLSP
GEASNTLPIF LIEPESVFVV KNRPAVLKCK ASHSLQVIFK CSGSSQPPPS THETHVDPHT
GVNMEEVTAT IHRDLVDEFF GDGPFKCECH AWSSRGVVKS QAATVHIAYI RKSFNQSPTS
LRLELGSRAE LRCEPPGGFP EPKLTWHKNN AVITADSEPG ITVSAGTLIF RQVALQHMAN
YSCSAENIAG RRVSDSAVLI VYVNGGWSTW SPWRECKCAG KPSQGRKRSR TCNNPMPLNG
GAQCPGPQIQ KSADCAACPE DTQIVSPDGF DISSSKRMAR WSAWSDWSIC SAECIQVRRR
KCLTQGQTQI SSEAEEAGDL LLGAPGVGMA ALIAAAGVGA VGSPSEATGS SSDIIPGYGK
SLCAGKDIQT AECRGEQCQI GKDDFDWTLY LGLAFITAVC FAFGTALICC ARRGIRTNPH
YNMARSVMDA DYMPGVVEKK EMRMHIEASN MGYDYVNPGH RYLPGEHIMG MGIGCGGVTE
HHYDVPNLSA NYTNPIDHLS VDYLSETGES STADTSNSTF DMNGKLSILN ASKSSTYEML
GSAGGQLRLY GGELLLFVPE HAIGKHVKKH VSLLLLSDEC SRVSCATESS ILCSSVVHSA
PRNYSFVKPV ILKIPHCLVA PEQWHVHIYH ADSEHDELSV NWRRAVSVGE ETINTPMFVQ
LEATHVFIMT EQLGHFTVVA EPRIQQPSIK MKLLAFSQHT PPSNANCSLR IYVVKDFPNS
RDICANVEAK LGGSFLGESQ VFAFTLNSRN LNIRVRSADV EAAAPYEHAI PYQHILSNNS
ILHCEFSLRR QDQNSLCVDF GQGSEDDYYT FNIPAHSMSG SAEELASTTN TTISIDRQGN
YVNESCVMDF VQLPHATKRL ICGALDPPRA DERDWRLLAK KLNTDRYIAY FATKASPTEQ
ILNLWECRAN SSPGSSSNSV SHTIMALLLT LKEMGRQDVL DIIVETIGPL WI
//
