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Database: UniProt
Entry: A0A0B5DI45_9ACTN
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ID   A0A0B5DI45_9ACTN        Unreviewed;       723 AA.
AC   A0A0B5DI45;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:QEV41382.1};
DE   SubName: Full=Kinase {ECO:0000313|EMBL:AJE42884.1};
GN   ORFNames=CP978_25015 {ECO:0000313|EMBL:QEV41382.1}, SNOD_24685
GN   {ECO:0000313|EMBL:AJE42884.1};
OS   Streptomyces nodosus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE42884.1, ECO:0000313|Proteomes:UP000031526};
RN   [1] {ECO:0000313|Proteomes:UP000031526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA   Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT   "Sequence of the Streptomyces nodosus genome.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AJE42884.1, ECO:0000313|Proteomes:UP000031526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE42884.1,
RC   ECO:0000313|Proteomes:UP000031526};
RX   PubMed=26497174;
RA   Sweeney P., Murphy C.D., Caffrey P.;
RT   "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT   antibiotic production.";
RL   Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN   [3] {ECO:0000313|EMBL:QEV41382.1, ECO:0000313|Proteomes:UP000325763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV41382.1,
RC   ECO:0000313|Proteomes:UP000325763};
RA   Lee N., Cho B.-K.;
RT   "Streptomyces genome completion.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC       {ECO:0000256|ARBA:ARBA00007476}.
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DR   EMBL; CP009313; AJE42884.1; -; Genomic_DNA.
DR   EMBL; CP023747; QEV41382.1; -; Genomic_DNA.
DR   RefSeq; WP_043444500.1; NZ_JACHMR010000001.1.
DR   AlphaFoldDB; A0A0B5DI45; -.
DR   STRING; 40318.SNOD_24685; -.
DR   KEGG; snq:CP978_25015; -.
DR   HOGENOM; CLU_012300_4_1_11; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000031526; Chromosome.
DR   Proteomes; UP000325763; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000313|EMBL:QEV41382.1};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJE42884.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031526};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJE42884.1}.
FT   DOMAIN          91..188
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          433..494
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          644..718
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          525..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  78420 MW;  31C5E88263C997BC CRC64;
     MSAEATNPAT PVPSTPGTHR RKSRPRIDLL RLGRAALLGT AARDRLPDAI GHVAEAHRAH
     HPDADLEPLR RAYLLAESSH RGQMRKSGEP YITHPLAVTL ILAELGAETT TLTASLLHDT
     VEDTDVTLDQ VREQFGEEVR YLVDGVTKLE KVDYGAAAEP ETFRKMLVAT GSDVRVMSIK
     LADRLHNMRT LSVMRREKQE RIAKVTRDVL IPLAERLGVQ ALKTELEDLV FAILHPEEYK
     HTRELIAENA AQRDDPLAEM AEQTRAVLRE AGIPSEVLIR PRHFVSVHRI SRKRGRLRGA
     DFGRLLVLVN EDADCYGVLG ELHTCMTPVI SEFKDFIAVP KFNLYQSLHT AVAREDGEIA
     EVLIRTHQMH KVAEAGVIAL GNPYAPGSDD PAEGERADPT RPGWLSRLLE WQEAAPDADI
     FWSTLREDLA QDREITVFRP DGGALGLPEG ASCVDAAYAQ YGEDAHACIG ARVNGRLATL
     STVLRDGDTV QLLMGQDPAS EPSREWLEHA HTPAARIAIQ RRLATPPAPG EPSDGTPEPG
     TARPGAQASP DTGALGSTAR PPARPTPDAP GARTADAVVD LPGASVRLAG CCTPVPPDEI
     TGFAVRGGAV TIHRVQCSGA ARMKSAGRTE VGVRWGDTTE CRVTLVAESF GRPHLLADLT
     EAIALQGVAI VSATVEPPSQ QRVRHTYTLQ LPDAARLPAL MRAMRNVPGV YDVNRAQHPA
     AAY
//
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