ID A0A0B5DI45_9ACTN Unreviewed; 723 AA.
AC A0A0B5DI45;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:QEV41382.1};
DE SubName: Full=Kinase {ECO:0000313|EMBL:AJE42884.1};
GN ORFNames=CP978_25015 {ECO:0000313|EMBL:QEV41382.1}, SNOD_24685
GN {ECO:0000313|EMBL:AJE42884.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE42884.1, ECO:0000313|Proteomes:UP000031526};
RN [1] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AJE42884.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE42884.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [3] {ECO:0000313|EMBL:QEV41382.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV41382.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
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DR EMBL; CP009313; AJE42884.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV41382.1; -; Genomic_DNA.
DR RefSeq; WP_043444500.1; NZ_JACHMR010000001.1.
DR AlphaFoldDB; A0A0B5DI45; -.
DR STRING; 40318.SNOD_24685; -.
DR KEGG; snq:CP978_25015; -.
DR HOGENOM; CLU_012300_4_1_11; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:QEV41382.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJE42884.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000031526};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJE42884.1}.
FT DOMAIN 91..188
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 433..494
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 644..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 78420 MW; 31C5E88263C997BC CRC64;
MSAEATNPAT PVPSTPGTHR RKSRPRIDLL RLGRAALLGT AARDRLPDAI GHVAEAHRAH
HPDADLEPLR RAYLLAESSH RGQMRKSGEP YITHPLAVTL ILAELGAETT TLTASLLHDT
VEDTDVTLDQ VREQFGEEVR YLVDGVTKLE KVDYGAAAEP ETFRKMLVAT GSDVRVMSIK
LADRLHNMRT LSVMRREKQE RIAKVTRDVL IPLAERLGVQ ALKTELEDLV FAILHPEEYK
HTRELIAENA AQRDDPLAEM AEQTRAVLRE AGIPSEVLIR PRHFVSVHRI SRKRGRLRGA
DFGRLLVLVN EDADCYGVLG ELHTCMTPVI SEFKDFIAVP KFNLYQSLHT AVAREDGEIA
EVLIRTHQMH KVAEAGVIAL GNPYAPGSDD PAEGERADPT RPGWLSRLLE WQEAAPDADI
FWSTLREDLA QDREITVFRP DGGALGLPEG ASCVDAAYAQ YGEDAHACIG ARVNGRLATL
STVLRDGDTV QLLMGQDPAS EPSREWLEHA HTPAARIAIQ RRLATPPAPG EPSDGTPEPG
TARPGAQASP DTGALGSTAR PPARPTPDAP GARTADAVVD LPGASVRLAG CCTPVPPDEI
TGFAVRGGAV TIHRVQCSGA ARMKSAGRTE VGVRWGDTTE CRVTLVAESF GRPHLLADLT
EAIALQGVAI VSATVEPPSQ QRVRHTYTLQ LPDAARLPAL MRAMRNVPGV YDVNRAQHPA
AAY
//