ID A0A0B5DK89_9ACTN Unreviewed; 512 AA.
AC A0A0B5DK89;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:MBB4795645.1};
DE SubName: Full=D-alanine--poly(Phosphoribitol) ligase {ECO:0000313|EMBL:QEV42554.1};
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:AJE44063.1};
GN ORFNames=BJY54_006257 {ECO:0000313|EMBL:MBB4795645.1}, CP978_32045
GN {ECO:0000313|EMBL:QEV42554.1}, SNOD_31750
GN {ECO:0000313|EMBL:AJE44063.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE44063.1, ECO:0000313|Proteomes:UP000031526};
RN [1] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AJE44063.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE44063.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [3] {ECO:0000313|EMBL:QEV42554.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV42554.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MBB4795645.1, ECO:0000313|Proteomes:UP000544950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40109 {ECO:0000313|EMBL:MBB4795645.1,
RC ECO:0000313|Proteomes:UP000544950};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009313; AJE44063.1; -; Genomic_DNA.
DR EMBL; JACHMR010000001; MBB4795645.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV42554.1; -; Genomic_DNA.
DR RefSeq; WP_043446812.1; NZ_JACHMR010000001.1.
DR STRING; 40318.SNOD_31750; -.
DR KEGG; snq:CP978_32045; -.
DR HOGENOM; CLU_000022_2_12_11; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR Proteomes; UP000544950; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:QEV42554.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031526}.
FT DOMAIN 11..364
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 426..498
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 512 AA; 54875 MW; 17B8AA350A4B60EB CRC64;
MSGPGTLYAR FARSAERYGD DTTALEVGED RLGYARLREL AERLAARLVA ASGAVPPRRV
GLLAGRSVTA YAGYLAVLRA GATVVPLNPE HPQARTVDIV KAAEVEVVLT DTAGAGTGLG
VPVLTVPPGD LIPLGDGPAP RLPEPGTGPD DIAYLIFTSG STGTPKGVPI AHRNICAYLD
RVAPRYDIAP GSRLSQSFEL TFDGSVHDLF VAWEGGGTLV VPRRGQLLSP VKAINKLRLT
HWFSVPSLIS FASRLGTLEP GSMPTLRWSV FGGEPLTLEA ARAWRAAAPA GRLEVLYGPT
ELTISCTAYR FPDDPAAWPD TPNGTAPIGT AHPSLEVLLL DQEGRPADSG ELCVRGPLRF
PGYLDPANDA GRFLTPEGRP CGDGPPTGRH WYRTGDRVMV RDGRLIHLGR TDHQVKIRGH
RIELGELEAM LRRQPGVRDA VVLAVHAADG EPELEAAVEG TGCTPEGLFA ALGERLPPYM
LPRRVAVREQ LPLNTNGKID RRGLLEELRR SR
//
