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Database: UniProt
Entry: A0A0B5EN59_STRA4
LinkDB: A0A0B5EN59_STRA4
Original site: A0A0B5EN59_STRA4 
ID   A0A0B5EN59_STRA4        Unreviewed;       765 AA.
AC   A0A0B5EN59;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SLNWT_3642 {ECO:0000313|EMBL:AJE84018.1};
OS   Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM
OS   4703 / NBRC 107858).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE84018.1, ECO:0000313|Proteomes:UP000031523};
RN   [1] {ECO:0000313|EMBL:AJE84018.1, ECO:0000313|Proteomes:UP000031523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC   {ECO:0000313|Proteomes:UP000031523};
RA   Lu C.;
RT   "Enhanced salinomycin production by adjusting the supply of polyketide
RT   extender units in Streptomyce albus DSM 41398.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP010519; AJE84018.1; -; Genomic_DNA.
DR   EnsemblBacteria; AJE84018; AJE84018; SLNWT_3642.
DR   KEGG; sals:SLNWT_3642; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   Proteomes; UP000031523; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031523};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031523}.
FT   DOMAIN      458    586       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      672    741       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     466    473       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   765 AA;  84936 MW;  27BC919E280BD279 CRC64;
     MLDQLLGIGD GGGHGIEAKD ERWIRRCLPL GLVADTALLA VPNEFAKGVL EGRLAPVVGS
     SLSREYGRRI RIAITVDENA GEAPAPGLPG QQQRYEEPEL PSAAPGRETY EGYARRSGEE
     HPGHGRGDSV PAARSEARPD SLPTARPAYP SEYQRPEPGA WPRTGQDDYG WQQQRLGFPE
     RESYTGPAPQ QQGHDYRGGE RGYDAERPPY EQDRGGYEAD RSSYEQERPY EKDRPYDKER
     PSYEGERPYD GERPGYESER AGYEQERPAA DRRGAERGGY ESERPPYERE RERGERPGYE
     AERLPYEQRM DFERGDRGER APAERGDRGE LGAYEKSRGE YEQPRGEYER PELRELPDRR
     PPSAPDPGGQ SPSGGPGPRG GPPSSRGHVH AGGPVGSSLP ASSGAPGPLA AKPAPATGPG
     EPTARLNPKY LFDTFVIGAS NRFAHAAAVA VAEAPAKAYN PLFIYGESGL GKTHLLHAIG
     HYARSLYPGT RVRYVSSEEF TNEFINSIRD GKGDSFRKRY REMDILLVDD IQFLADKEST
     QEEFFHTFNT LHNANKQIVL SSDRPPKQLV TLEDRLRNRF EWGLITDVQP PELETRIAIL
     RKKAVQEQLN APPEVLEFIA SRISRNIREL EGALIRVTAF ASLNRQPVDL GLTEIVLKDL
     IPGGEDAAPE ITATAIMAAT ADYFGLTVDD LCGSSRSRVL VTARQIAMYL CRELTDLSLP
     KIGAQFGGRD HTTVMHADRK IRALMAERRS IYNQVTELTN RIKNG
//
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