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Database: UniProt
Entry: A0A0B5HS46_9ARCH
LinkDB: A0A0B5HS46_9ARCH
Original site: A0A0B5HS46_9ARCH 
ID   A0A0B5HS46_9ARCH        Unreviewed;       309 AA.
AC   A0A0B5HS46;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN   ORFNames=QT06_C0001G0185 {ECO:0000313|EMBL:AJF61032.1};
OS   archaeon GW2011_AR15.
OC   Archaea.
OX   NCBI_TaxID=1579373 {ECO:0000313|EMBL:AJF61032.1, ECO:0000313|Proteomes:UP000031776};
RN   [1] {ECO:0000313|EMBL:AJF61032.1, ECO:0000313|Proteomes:UP000031776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Castelle C.J., Wrighton K.C., Thomas B.C., Hug L.A., Brown C.T.,
RA   Wilkins M.J., Frischkorn K.R., Tringe S.G., Singh A., Markillie L.M.,
RA   Taylor R.C., Williams K.H., Banfield J.F.;
RT   "Genomic expansion of domain Archaea highlights roles for organisms
RT   from new phyla in anaerobic carbon cycling.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; CP010425; AJF61032.1; -; Genomic_DNA.
DR   Proteomes; UP000031776; Chromosome.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   Gene3D; 1.10.472.10; -; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 1.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031776};
KW   Initiation factor {ECO:0000313|EMBL:AJF61032.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Protein biosynthesis {ECO:0000313|EMBL:AJF61032.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031776};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN        5     36       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      117    200       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      211    292       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING       5     36       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   METAL         9      9       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        12     12       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        28     28       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        31     31       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   309 AA;  34993 MW;  C712E3473A2EA03B CRC64;
     MDRDIVRKCP ECGGVNLFWN KEKGEVICKD CGLVVEEKMV DFGQEWREFD SDSGESRRRT
     GAPITYTQYD QGLGTEVGRK ADLYSLTNKS KNKFFRLRKW QYRISTAIER NLKLALAELK
     RVSSYLKLPK SVEEEAARIY TMAVQRGLVR GRSMESVVAG ALYAACRRHE VPRTLDELSE
     ASGIEKKEVG RTYRFITREL AISILPSNPI DYIPRFSSSL KLSPKTQSKA VEIIEMAQKQ
     ELTSGRGPTG IAAAGLYVAA LINGEKRTQR EVADVAGVTE VTIRNRYKEL LDKLDLENEI
     KKLKKKSKD
//
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