ID A0A0B6WYQ7_9BACT Unreviewed; 747 AA.
AC A0A0B6WYQ7;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=PYK22_01283 {ECO:0000313|EMBL:CDM65285.1};
OS Pyrinomonas methylaliphatogenes.
OC Bacteria; Acidobacteriota; Blastocatellia; Blastocatellales;
OC Pyrinomonadaceae; Pyrinomonas.
OX NCBI_TaxID=454194 {ECO:0000313|EMBL:CDM65285.1, ECO:0000313|Proteomes:UP000031518};
RN [1] {ECO:0000313|EMBL:CDM65285.1, ECO:0000313|Proteomes:UP000031518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K22 {ECO:0000313|EMBL:CDM65285.1,
RC ECO:0000313|Proteomes:UP000031518};
RA Stott M.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDM65285.1, ECO:0000313|Proteomes:UP000031518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K22 {ECO:0000313|EMBL:CDM65285.1,
RC ECO:0000313|Proteomes:UP000031518};
RA Lee K.C.Y., Power J.F., Dunfield P.F., Morgan X.C., Huttenhower C.,
RA Stott M.B.;
RT "Complete genome sequence of Pyrinomonas methylaliphatogenes type strain
RT K22T.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the anti-sigma-factor family.
CC {ECO:0000256|ARBA:ARBA00037972}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CBXV010000004; CDM65285.1; -; Genomic_DNA.
DR RefSeq; WP_060635411.1; NZ_CBXV010000004.1.
DR AlphaFoldDB; A0A0B6WYQ7; -.
DR STRING; 454194.PYK22_01283; -.
DR Proteomes; UP000031518; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR35526; ANTI-SIGMA-F FACTOR RSBW-RELATED; 1.
DR PANTHER; PTHR35526:SF1; SERINE-PROTEIN KINASE RSBW; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CDM65285.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031518};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:CDM65285.1}.
FT DOMAIN 628..739
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF13581"
SQ SEQUENCE 747 AA; 84345 MW; 65EFC172BFA4DF2A CRC64;
MSSEAQNRRH PILGHVARAD FVGRDAELQR IVNLARRETA ERGLFLLAPP GAGLSELLRQ
SYDALFHDEL AIPIYFAWSL HDRTASAAAR HFLQTFLLQL TAYRRREPAL IDAHPTLNDL
LQLAAPSDYV WLEQLLESYE QVRADGDERQ LVRLCLSAPQ RAAAGGVTTV LLFDDVHLAE
HLSGETALGA EVARACIRAG TPFVIAGLRR RVLEVVSAAD MLFEQTGTLH LDLLSEADAR
SLIERWAARR QIRLNGATCD LIVQELKGRP FFLTALLRAA QEAKEDLDNF LACQRLYVDE
LLGGRINRRF AEVWERIVPN GAMRRAFVRA LYETANAAQG QSPVEAWLKR LSMSSDELQR
TLRQMHAQEL INFSGTFIEV ADDTVWRDYL EITYRLEVAA ERRALVVADT LLSLLMRAPQ
TMARRYRSEA ALHLRELLAR FNCQRVPASL LHYDRFSRMY KGMEPEAIAS ALDAETDLVL
LPQIIHTAPC LAFHQSFERL CEEAQCVVAH GFDAGQYAEA NQIVWLAAEI EAKVEVGRAV
AEMWHNRLVE LARSCGFKRF RVWLVAPAGF SAEACEFLRE REAYGSNRQQ LEFLTARLSV
PLSKSTTEAQ ADEFEMVIPI GEDTELIAAH TVEQIARRLN FEPEAINQIK VALVEACLNV
AEHSLSPERK IYQRFRAESD RLVITVWSRG VAFHGEPNNN GKQTSGRSKR GLGLKLIRTL
MDEVEFKRVD DGACLRMTKY LHPRTSS
//
