ID A0A0B7H3T9_9FLAO Unreviewed; 1821 AA.
AC A0A0B7H3T9;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:CEN34246.1};
GN ORFNames=CCYN2B_20046 {ECO:0000313|EMBL:CEN34246.1};
OS Capnocytophaga cynodegmi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=28189 {ECO:0000313|EMBL:CEN34246.1, ECO:0000313|Proteomes:UP000038055};
RN [1] {ECO:0000313|Proteomes:UP000038055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ccyn2B {ECO:0000313|Proteomes:UP000038055};
RA MANFREDI Pablo;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CDOD01000012; CEN34246.1; -; Genomic_DNA.
DR RefSeq; WP_041991392.1; NZ_CDOD01000012.1.
DR STRING; 28189.CCYN74_80044; -.
DR eggNOG; COG2373; Bacteria.
DR Proteomes; UP000038055; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000038055};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1821
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002115735"
FT DOMAIN 959..1101
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1165..1256
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1821 AA; 204107 MW; 2D98ECB8CFBA3967 CRC64;
MRKVILFLTA LLTLFACKKD TAIFNSNPLL YKDYISGFTS GIVSAETSFK LLFNEAISQE
KIAKINDLDL FEVSPKVKGK VICLNPYEVE FIPEKRLEQD TEYKVSFNLK KLFSVSEGLE
IFNFSIKTLQ QGYKIKEGDL QSYNENLYFL NAELLSSDKI SYEKAKKLIS AKLGSKKISV
KFLSQSSSNK FSIVFDSIPR LDNEQTLQVS WNANDVPSEN LLPFSTLIPE KGSFKAISTK
TESSSNQSFT INFSEPLEKN QNFNGLVNLS NTDTELKYSV NGNVLKVFRE ASDEGDFQVF
VHGGIRSVYG KRIDDSKTFD ISFLQQKPEI RLVKNGTILP SSQNLKIHFQ AINLRAVNAV
VYRIYENNIL QFLQENSLGS NYGLQRVGKP IAKKVIQLSE NALSPLKEWN TYSLDLSSVI
TPEPGAIYRV EFTMKKNYSL YACGSENEPL DLSFEEEPLE NEPEDYEEDY YYWGSSDNPC
DDYFYNKTLG TNVLASDLGV IVKKGQNNNF VVVVNNILNT EPVSGAVVEV FDYQQQKIQE
GKTDGDGIVK FDISNRAFFA KVKKDNNTTY VKMDDAAPQS VSKYDVDGLR LQKGLNGFIY
AERGVWRPGD SIHVGFVLND FAQKLPEKLP IKLKFTDPYG KVIAERVQSS NPVNHYVFGL
KTSPEAPTGN WNVSISAGAA KFHKSIKIET IKPNRLKIEN SLNEKLISAN GANANLQVLW
LHGSPAGNTQ VSVKAKFYPK ETAFKGYEKY IFNNEAYQFE NQEISVYEGR TDSQGKTNFY
FKANELQAPG MLRVNFLTQA NESGGDFSTD VTTASFSPYE SYVGLRLPEA NKYDYYNTEE
NHIFEVATLS ENGEPLRGQN VSVTVYKVGW NWWWDASNQN ISTYNSSSSN VIYTTKVIET
DGRGKAKFDL KIPDEDWGRY FILLSDEQSG HKSGTTVYFD WGSWSGKSRK ASSEEAIMLS
LGGNKKEYNV GEKAKISFPS DEGGRALISV ENGNDVLETY WVETKSAETS YEILITEKMA
PNVYLYVTLL QPHTNSINDA PIRLYGVLPI SVVDKETQLN PVIQMADVLR PKQKTTVKIS
EKSGKPMTYT LAIVEDGLLN LTRFKTPNPW NKFFSKTALG VKTWDVYNDV IGAYGGTVNQ
AFSIGGDEDL GGADAQKANR FKPFVIVKGP YNLKKGNTNV HDVEIPNYIG SARVMVVASD
VAKNAFGSAE KKDIPVVSPL SLLGSLPRKA VPGERITLPV TVFAMEKSVR NATISVETNA
HFKVVGNKSQ SLQFDSAGEK MAYFELEVAQ QTGIGKVKIT AVSGSEKATY EVEMDVYNPN
PVTYFVQNEV LTEGSTQSLN TPVFGENAKS VLEISSFPGV NLHQRLNYLI SYPHGCGEQI
TSGAFPQLFL SDFINLTPEK AESVQRNVTT AISKLHENQL PNGGFAYWKG NSYADDWATS
YIGHFFISAE KKGYVLPSGS KQNWLDYQNN EARQWRYEPQ YQNDFAQAYR LYTLALAGEP
NMGAMNRLRE TKDISSNAKR LLAASYAIAG QKQTANNLFQ SVAVNDDYDN YYYYGSEVRN
KAMALETALL IGKKEDAARW ALEIANRLSS SDWMSTQTTA YALYAMAKYV EINKSGKSFS
ASYSLRGKTE NIKSDEPMAS VELPVKGDKE LLQVKNTSKQ TLYARLISSG VLPIGKELPM
QNGLTITTTY RDKNGNWVDV SQLRQSTELI ASIEVKNLTN EPVENVALTQ IIPSGWEIIN
TRFTDYGDTE QSSYIDYTDF RDDRANFYFP LKGNQVKVIK LKINASYAGR YYLPGTFAEA
MYNNRYNTRT EGKWVEVYQG E
//
