ID A0A0B7I935_9FLAO Unreviewed; 780 AA.
AC A0A0B7I935;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=pcrA {ECO:0000313|EMBL:CEN46413.1};
GN ORFNames=CCAND38_340013 {ECO:0000313|EMBL:CEN46413.1};
OS Capnocytophaga canis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1848903 {ECO:0000313|EMBL:CEN46413.1, ECO:0000313|Proteomes:UP000045051};
RN [1] {ECO:0000313|EMBL:CEN46413.1, ECO:0000313|Proteomes:UP000045051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CcD38 {ECO:0000313|EMBL:CEN46413.1,
RC ECO:0000313|Proteomes:UP000045051};
RA MANFREDI Pablo;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CDOI01000145; CEN46413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B7I935; -.
DR Proteomes; UP000045051; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000045051}.
FT DOMAIN 6..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 780 AA; 88979 MW; C40308BF19F41C31 CRC64;
MEKYLAQLND AQRAPVLQKE GPLMVIAGAG SGKTRVLTYR IANLIHLGVD AFNILALTFT
NKAANEMKKR ITEIVGNEAK NLWMGTFHSV FAKILRIEAD KLGYPQNFTI YDTQDSQRLI
NSIIKEMELD KDVYKYKQIQ SRISSFKNSL ITVRAYFNNP ELMEADAMSK RPRMGEIYQA
YVERCFKAGA MDFDDLLLKT NELLNLYPDV LAKYQHRFQY ILVDEYQDTN HSQYLIVKAL
ADRFQNICVV GDDAQSIYAF RGANINNILN FQQDYQNARV YRLEQNYRST KNIVEAANSV
IDHNKTKLEK VVWTANELGE PIKIHRSPTD SDEGRFVAGS IFENKMNLQL PNSAFAVLYR
TNSQSRAIED ALRKRDIPYR IYGGLSFYQR KEVKDMLAYL RLIINPNDEE ALVRIINFPA
RGIGGTTLEK LTFAANHYKK SIFEIMYKIN QIDGLNMNAS TKQRLTDFVV MILNFQSLSK
TSNAFEIAEQ VARKTGLLQE LKKDGTPEGI AKMENIEEML NGIKDFVEGQ EDVADSTASL
AEYLEDVALV TDMDKDTGDD DRVALMTIHL AKGLEFPYVY IVGMEEDLFP SAMSVNSRAE
LEEERRLFYV ALTRAEKQAY LTYAENRYRW GKLSDAEPSR FIDEINNQYV QYLTAPINNP
NYRYKPLINR DIFGEVDKSR LRLQKPTNST PPPSHAPKGD ELQRLRKLKP MNSSSIGNGS
NPNQGVALSE GMFVFHERFG KGKIISLEGV GSDRKASIDF ESGGVRKILL KFAKLQVIEK
//
