ID   A0A0B7MIE0_9FIRM        Unreviewed;       357 AA.
AC   A0A0B7MIE0;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Theronine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:CEO87417.1};
GN   ORFNames=SSCH_1020022 {ECO:0000313|EMBL:CEO87417.1};
OS   Syntrophaceticus schinkii.
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Syntrophaceticus.
OX   NCBI_TaxID=499207 {ECO:0000313|EMBL:CEO87417.1, ECO:0000313|Proteomes:UP000046155};
RN   [1] {ECO:0000313|Proteomes:UP000046155}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sp3 {ECO:0000313|Proteomes:UP000046155};
RA   Manzoor Shahid, Zubair Saima;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CDRZ01000005; CEO87417.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B7MIE0; -.
DR   OrthoDB; 9777057at2; -.
DR   Proteomes; UP000046155; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd05278; FDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046155};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          4..345
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   357 AA;  39087 MW;  FF81FAB94B157DB0 CRC64;
     MLQRTMKALL WKEDKGIDIV DAPVPKITKP TDAIVRVTLS TICASDIHIV GGHTYVQPPQ
     IIGHEFCGEV VELGSAVTKF NVGDKVAVSC LPFCGDCYFC QRGLHFQCLD PDCTCFGTNM
     GELKLDGCQA EYIRVPHSAN TMYKIPDGFT EEDMLFVGDI LSTGYFATEK GNIQPGDTVL
     IIGAGPVGMC AAITTKLWGP SKIIISDRVQ SRLDVCLKEG IVDFALNPDE VDVTEKCREL
     TDGLGPDVVL ECIGLEPTLV QACQAVRMGG NVVTIGVYEG PVTLPMADIW FKNISISMGF
     VPMNRMPELI KLIQGGRINT KFLMTHRAPL NDIVKGYDVF GNKKDNCLKW VVTPYEK
//