ID A0A0B8NB29_9NOCA Unreviewed; 863 AA.
AC A0A0B8NB29;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=NS07_v2contig00095-0023 {ECO:0000313|EMBL:GAM49070.1};
OS Nocardia seriolae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=37332 {ECO:0000313|EMBL:GAM49070.1, ECO:0000313|Proteomes:UP000019401};
RN [1] {ECO:0000313|EMBL:GAM49070.1, ECO:0000313|Proteomes:UP000019401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N-2927 {ECO:0000313|EMBL:GAM49070.1,
RC ECO:0000313|Proteomes:UP000019401};
RA Imajoh M., Fukumoto Y., Yamane J., Sukeda M., Shimizu M., Ohnishi K.,
RA Oshima S.;
RT "Draft Genome Sequence of Nocardia seriolae Strain N-2927 (NBRC 110360),
RT Isolated as the Causal Agent of Nocardiosis of Yellowtail (Seriola
RT quinqueradiata) in Kochi Prefecture, Japan.";
RL Genome Announc. 3:e00082-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAM49070.1}.
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DR EMBL; BAWD02000095; GAM49070.1; -; Genomic_DNA.
DR RefSeq; WP_052486729.1; NZ_BBYQ01000100.1.
DR AlphaFoldDB; A0A0B8NB29; -.
DR STRING; 37332.NS506_01724; -.
DR Proteomes; UP000019401; Unassembled WGS sequence.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000019401};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 571..655
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 669..748
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
SQ SEQUENCE 863 AA; 93556 MW; 496E6C77CC9770EF CRC64;
MDRRRFLKHA AHLGGAAGSM SMLPPSLVQA WAEPAPPGGW DRIEHVVILM QENRSFDHYY
GGMAGVRGYA DLNALQLSTG RSVFHQPDGG RTVLPYLTTL QNIDGTDHGT RTGHEAFASG
RHDRWIAAKG DGTMVGYDRD CLGFYYQLAE AFTVCDGYHC SVNGPTDPNR MYLFTGTVKK
PLALDNFAES LQTSLFADDA KLRWMRSLPV EGIVDAVLGM VHGLTSALPQ PVAQALTGLV
APRTGNLFMY DALLGPDAGR YVHEVVFGLP WTTYAERLEE RGIGWRVYQE WDNYTDNALD
FFLPFRDAAR AALKYTNGGG GLAFENFFRY YGDLQQDPSL EPAYTAALKR GMDELSPGQR
ALVEKGLLRA RSGTLVDSFH TDVATGRLPR VSWIVAPYVD CEHPVMGPRN GQALVHGVLE
ALAEHPDVWN KTVFILNYDE NDGYFDHIPA PTPPPGAAGE YFGSHNVGLG ARTPAIIVSP
WSKQAVCSEL FDHTSVLKFL ERVTGVAEPN ISPWRRQLCG DLSSLFDFGA RRTLIVPSAA
PRAEQSMSGA AQPLPFVQRM PKQQSGRKAR VPLPYRLQAR CVSGGTDSIT VTIDNGGTGA
AHCTVYPNAF AADYTPTRFD VAGGGTVGHD LPAVNGRYDY TVYGPDGFQR RFAGDLRGPC
AALRVTATAA TSGKRALTWS FENGGTQPVS VLVVSHAYRH DGPWTIDIDA GGTERRELSC
ESDAEGAGWY DFGVSASSDA GFRCRARGFV ENGMPGSTAD DAAPFDRLLL DRSTYEPGRD
LVVSYCLADA VAGHRLEVHP EESAGHVRTV ATSAAAATLS LGDGVGRDQV VFPASGLTSG
TYVLRHLDDA GRSLAHPVRF RVL
//
