ID A0A0B8NBN9_9NOCA Unreviewed; 3117 AA.
AC A0A0B8NBN9;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Fatty acid synthase {ECO:0000313|EMBL:GAM46092.1};
GN ORFNames=NS07_v2contig00023-0030 {ECO:0000313|EMBL:GAM46092.1};
OS Nocardia seriolae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=37332 {ECO:0000313|EMBL:GAM46092.1, ECO:0000313|Proteomes:UP000019401};
RN [1] {ECO:0000313|EMBL:GAM46092.1, ECO:0000313|Proteomes:UP000019401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N-2927 {ECO:0000313|EMBL:GAM46092.1,
RC ECO:0000313|Proteomes:UP000019401};
RA Imajoh M., Fukumoto Y., Yamane J., Sukeda M., Shimizu M., Ohnishi K.,
RA Oshima S.;
RT "Draft Genome Sequence of Nocardia seriolae Strain N-2927 (NBRC 110360),
RT Isolated as the Causal Agent of Nocardiosis of Yellowtail (Seriola
RT quinqueradiata) in Kochi Prefecture, Japan.";
RL Genome Announc. 3:e00082-15(2015).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAM46092.1}.
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DR EMBL; BAWD02000023; GAM46092.1; -; Genomic_DNA.
DR RefSeq; WP_036545387.1; NZ_BBYQ01000028.1.
DR STRING; 37332.NS506_02387; -.
DR Proteomes; UP000019401; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.2430; -; 1.
DR Gene3D; 3.30.70.2490; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 6.10.140.1400; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 2.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000019401}.
FT DOMAIN 2570..3025
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3117 AA; 329045 MW; BE468C19ADF15865 CRC64;
MTINESTGTG SKARAAGKSR ESGVRSSLLD RLLGGAPYAL AFGGQGAQWL SELEEIGRDS
ALEPELTALV NEAAAKLEPV ASQLLVVRPV GFDPVAWMLE EEIADPEQGE VSGAPSAQVL
RSAAVSMPGV FLTQIAALRA LRLQGLDIVA HAPAAVIGHS QGRIAATAAE EHGQRDAELL
AVAQLIGAAA GLVARRRGLL PVGEKSPMVA VSNVDPEALK AVVAEVMNGV AAEKAAVLSI
RNGRRRAVLS GPVAQLDRVR QRAAEINAEQ AKEREAKKRG GSVFAPVFED IPVEVAFHHP
ALQETVELVK GWAQQCGLDA ELAAALTQEV LVDPIDWVAI VDETVGQGAQ WILDLGPGDL
LSRLTSGSLK GTGVGVLAAS TRPGQRSLFT PGAAPEVAPA WGEFAPKPIR LPNGRIVVET
AFTKLTGRSP ILLAGMTPTT VDAKIVAAAA NAGHWAELAG GGQVTEQIFA DRVEELKSLL
HPGRAVQFNS LFLDPYLWKL QLGGKRIVQK ARSAGAPLDG VIVTAGIPEL EEAVALIEEL
TEVGISHVAF KPGTVAQIRA VLRIADSVPG YPVIMHIEGG KAGGHHSWED LDDLLLETYA
ELRGRDNVIV CVGGGIGSPE RATEYLTGEW SQQHGYPAMP LDGVLVGTAA MATLEATTAP
EVKQLLVDTP GTPDWVGAGT ASGGMASGRS QLGADIHEID NAASRTGRLL DEVAGDADAV
AERREEIIAA LHGTAKPYFG DAATMTYLEW LERYVELAAS LPQTHPDLDR RKDFDCGGDF
SDAIADATRS VWLDITWRDR FAEMVRRTES RLNPADRGEI ATLFAEDTAF ETPVKAICTL
KEQYPTAANT VLHPADVPFF VSLCKIPGKP VNFVPVVDQD VRRWWRSDSL WQAHDPRYTA
DQVCIIPGTV AVAGITRVDE PVGELLDRFE QNTAFSLVRA GIVPAAVDGR RRAEVADGLL
DIVLAAPDVQ WAGRTTVNPI HRLGNLDEWE MNGKGAKHPR TGATLSATEG TETDSAYVEL
AVPLLGKDAV KIRITVPVSV YNGGAPVITE DDASAAMSAL LAVAAGKSLP EVKTIDGAQV
AHVNLAWSPD LIADHAGVTG SGLPDSLSTI GRTVPDVLVG ACWPAVFAVL GATRTADEQS
VIEGMLDLVH LDHQIELLGE LPAEHAVLAV RAESAEVLDT DLGRVVEVKV AVGVMRDHGL
DTPPVAKLVE RFAIRGRTGS AELSDPPRAA GSLSEDASDT PRRRRRDVAL VAPRAMGAFA
QVSGDFNPIH TSENAAKLAG LGNPIVHGMW LSAAAQHAVS AIDLSDKVPP RTITAWTTRF
LGMVRLGSPV DVRVERVAVD HGSEIVEVSC RIDGNLVMTA TGRIAPSKTV YAFPGQGIQA
KGMGLDARTR SKAAKDIWDR ADKHTREALG FSILAVVRDN PTYLKARGVE YRHPQGVLHL
TQFTQVAMAT LGVAQVAELR EAGAFIEGAM LAGHSVGEYN ALSAAAGVLP LNAVLEVVFQ
RGSAMHELVP RDAQGRSDYR MCAIRPSQIG IADDQVIDWV KGIGEQAGEF LEVVNLNLRG
AQYAIAGTVK GCEALETEIE RLRAETGGKR AFVLIPGIDV PFHSTVLRAG VPEFRGKLLD
LLPQDLDPSL LIGRYIPNLV PRLFNLERDY IQEIADLVPS EPLAEVLANW DEWAAKEVEL
CRVVLVELLA WQFASPVRWI ETQDLLFTDV EHGGVGVERF VEIGLAATPT VANLASNTLK
LPQFGSAVVE VLNIERERGI VYSTDTDPAP VEEPEETPAE TASAATAPAA AAAPAPGAVP
TGGPTPDDIS FSAADATRVL IALWTKLRMD QIGPVDTIEG LCDGVSSRRN QLLVDLGAEL
SLGAIDGAAD ADMGALSGTV ERLARTYKPF GSVLSDAIGD HLRKVFGPSG KRPAAIGERV
KKVWGLGDGW ASHVTAEVSL GTREGASVRG GDLGGLVSGG LSDAASVDAA IDAAVQAVAA
RRGVAVSMPS VGGGGGATVD AAALGEFTEQ ITGRDGVLAQ AARVILESLG HAEQASAPEA
TEDTLVDLVS AELGSDWPRL VAPAFDARKA VLIDDRWASA REDLARLWFG NDGSLPVEPE
VDGYYGAGEA VAAQANWWRN RAMKEARSVL AGVYGAIAEA AVSAAEPGIW SSDIAVITGA
SKGSIAAAAT GRLLAGGATV VVTTSKLDDD RLGFYKQLYR DNARNGAALW VVPANMASYS
DIDALIEWVG NEQVDNAGGA KVLVKEAMTP TLLLPFAAPR VAGDLSDAGA RAEMEMRVLL
WSVERLIGGL SKIGADHDVD AKLHVVLPGS PNRGMFGGDG AYGESKAALD AIVAKWRAEK
SWSERVTLVH ALIGWVRGTG LMGGNDPLVE AVEKAGVHTW STLQMADELL KWCTSRARVV
TAAGPQQIDL TGGLAGAKLD LPELAREARE QAEAAAAEES EGVDAKTISA LPAPPTMSSE
LPTLEWGSVT ADLDDMVVIV GAGELGPYGS ARTRFEIEVS DQLSAAGVLE LAWTTGLVTW
ENDPKPGWYD TESGEYVEES ELADRYHDTV VERCGVRRYG DDGAMIDNAA PLLTSVFLDD
DLTFVVNSEA EARAFYSANP EQTVVTPIEG TGDWQVIRKA GTEIRVPRKA RLSRTVGGQI
PTGWDPTRWG ISADMAGSID RVALWNIVCT VDAFLSSGFS PAELMSWVHP AMVANTQGTG
MGGMSSMRSL YIDNLLGESR PNDILQEALP NVALAHVVQS YVGSYGGMIH PVAACATAAV
SVEEGVDKIK LGKADLVVAG GYDDLGIEGI VGFGDMSATA DSAAMYAKGI SDRYFSRAND
RRRGGFVESQ GGGTVLLARG SVALEMGLPV LGVVAYAQSF ADGVHTSIPA PGLGALGAGR
GGPESKLAKE LRKLGVAPDE IAVVSKHDTS TAANDPNESE LHERLATSLG RSEGAPLFVV
SQKALTGHAK GGAAAFQMIG LCQVLAQGVI PPNRSLDCVD EKMAQYPHLV WLRETLNVGD
RLPLKAGLVT SLGFGHVSGL VAIVHPQAFV EAIADAEQRE AYQRKAEERQ LAGRQRFAEA
MCGGAPLYER PADRRLGGDG TPAKKSRQLE ADVLLSQQAR LGSDAVYVAV PKGPACQ
//
