ID A0A0C1ITW8_9BACT Unreviewed; 518 AA.
AC A0A0C1ITW8;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=signal peptidase I {ECO:0000256|ARBA:ARBA00013208};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208};
GN ORFNames=OI18_14980 {ECO:0000313|EMBL:KIC93889.1};
OS Flavihumibacter solisilvae.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Flavihumibacter.
OX NCBI_TaxID=1349421 {ECO:0000313|EMBL:KIC93889.1, ECO:0000313|Proteomes:UP000031408};
RN [1] {ECO:0000313|EMBL:KIC93889.1, ECO:0000313|Proteomes:UP000031408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3-3 {ECO:0000313|EMBL:KIC93889.1,
RC ECO:0000313|Proteomes:UP000031408};
RA Zhou G., Li M., Wang G.;
RT "Genome sequence of Flavihumibacter solisilvae 3-3.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677};
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIC93889.1}.
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DR EMBL; JSVC01000016; KIC93889.1; -; Genomic_DNA.
DR RefSeq; WP_039141182.1; NZ_JSVC01000016.1.
DR AlphaFoldDB; A0A0C1ITW8; -.
DR STRING; 1349421.OI18_14980; -.
DR OrthoDB; 9802919at2; -.
DR Proteomes; UP000031408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 2.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 2.
DR InterPro; IPR043739; DUF5684.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019533; Peptidase_S26.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF18936; DUF5684; 1.
DR Pfam; PF10502; Peptidase_S26; 2.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031408};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..310
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT DOMAIN 420..501
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 158
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 287
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 518 AA; 59927 MW; C14B2A9F5760D397 CRC64;
MTTNQILIVA LISLIIFILP AFGLYKLFQK AGTPGWKGLI PLYNTWVMLE IAQRPKHWFF
WQLIPVAGWF VTMGIFIEFI KCFGKFSFWE HALTCLVPFL YFPYVAMDQK TRFIGPQGVK
HYQKSTVREW VDAGIFAIVA ATLIRTFIFE AYTIPTGSME KTLLINDFLF VSKLSYGPRI
PNTPLSIPFM HHTIPGTSSR SYSELVKLPY SRWFESPVKR NDVVVFNFPT GDTVINRPEF
QSQDPYYDFA RRIGSGDINK GRQAVLSDPE TYPLVIRPVD KRENYIKRCV AIGGDTLEVR
DGRVYIDGKP GFIPPHSQIF YEVETNGQPL NAEVMKEEYN VDIENPDEIF SISGNKYGML
LTAEAVDKMK SSGLAKSITP QLIRPDQVDP RLWGTICFPY DTIHKWTVDS FGPIWIPKKG
ATLTITPENY SIYERAIRVY EGNTLERQNN KFVINGQETD KYTFKMDYYW MMGDNRHLSQ
DSRFWGFVPE DHVVGEAWII WMSINKGIRW NRLFRSIK
//