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Database: UniProt
Entry: A0A0C1ITW8_9BACT
LinkDB: A0A0C1ITW8_9BACT
Original site: A0A0C1ITW8_9BACT 
ID   A0A0C1ITW8_9BACT        Unreviewed;       518 AA.
AC   A0A0C1ITW8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=signal peptidase I {ECO:0000256|ARBA:ARBA00013208};
DE            EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208};
GN   ORFNames=OI18_14980 {ECO:0000313|EMBL:KIC93889.1};
OS   Flavihumibacter solisilvae.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Flavihumibacter.
OX   NCBI_TaxID=1349421 {ECO:0000313|EMBL:KIC93889.1, ECO:0000313|Proteomes:UP000031408};
RN   [1] {ECO:0000313|EMBL:KIC93889.1, ECO:0000313|Proteomes:UP000031408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-3 {ECO:0000313|EMBL:KIC93889.1,
RC   ECO:0000313|Proteomes:UP000031408};
RA   Zhou G., Li M., Wang G.;
RT   "Genome sequence of Flavihumibacter solisilvae 3-3.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC         from secreted and periplasmic proteins.; EC=3.4.21.89;
CC         Evidence={ECO:0000256|ARBA:ARBA00000677};
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
CC       {ECO:0000256|ARBA:ARBA00009370}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIC93889.1}.
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DR   EMBL; JSVC01000016; KIC93889.1; -; Genomic_DNA.
DR   RefSeq; WP_039141182.1; NZ_JSVC01000016.1.
DR   AlphaFoldDB; A0A0C1ITW8; -.
DR   STRING; 1349421.OI18_14980; -.
DR   OrthoDB; 9802919at2; -.
DR   Proteomes; UP000031408; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd06530; S26_SPase_I; 2.
DR   Gene3D; 2.10.109.10; Umud Fragment, subunit A; 2.
DR   InterPro; IPR043739; DUF5684.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR   PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR   Pfam; PF18936; DUF5684; 1.
DR   Pfam; PF10502; Peptidase_S26; 2.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031408};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          128..310
FT                   /note="Peptidase S26"
FT                   /evidence="ECO:0000259|Pfam:PF10502"
FT   DOMAIN          420..501
FT                   /note="Peptidase S26"
FT                   /evidence="ECO:0000259|Pfam:PF10502"
FT   ACT_SITE        158
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT   ACT_SITE        287
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ   SEQUENCE   518 AA;  59927 MW;  C14B2A9F5760D397 CRC64;
     MTTNQILIVA LISLIIFILP AFGLYKLFQK AGTPGWKGLI PLYNTWVMLE IAQRPKHWFF
     WQLIPVAGWF VTMGIFIEFI KCFGKFSFWE HALTCLVPFL YFPYVAMDQK TRFIGPQGVK
     HYQKSTVREW VDAGIFAIVA ATLIRTFIFE AYTIPTGSME KTLLINDFLF VSKLSYGPRI
     PNTPLSIPFM HHTIPGTSSR SYSELVKLPY SRWFESPVKR NDVVVFNFPT GDTVINRPEF
     QSQDPYYDFA RRIGSGDINK GRQAVLSDPE TYPLVIRPVD KRENYIKRCV AIGGDTLEVR
     DGRVYIDGKP GFIPPHSQIF YEVETNGQPL NAEVMKEEYN VDIENPDEIF SISGNKYGML
     LTAEAVDKMK SSGLAKSITP QLIRPDQVDP RLWGTICFPY DTIHKWTVDS FGPIWIPKKG
     ATLTITPENY SIYERAIRVY EGNTLERQNN KFVINGQETD KYTFKMDYYW MMGDNRHLSQ
     DSRFWGFVPE DHVVGEAWII WMSINKGIRW NRLFRSIK
//
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