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Database: UniProt
Entry: A0A0C1M7L2_9LACO
LinkDB: A0A0C1M7L2_9LACO
Original site: A0A0C1M7L2_9LACO 
ID   A0A0C1M7L2_9LACO        Unreviewed;       446 AA.
AC   A0A0C1M7L2;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LfDm3_0378 {ECO:0000313|EMBL:KID42449.1};
OS   Lactobacillus fructivorans.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1614 {ECO:0000313|EMBL:KID42449.1, ECO:0000313|Proteomes:UP000031397};
RN   [1] {ECO:0000313|EMBL:KID42449.1, ECO:0000313|Proteomes:UP000031397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DmCS_002 {ECO:0000313|EMBL:KID42449.1,
RC   ECO:0000313|Proteomes:UP000031397};
RA   Newell P.D., Chaston J.M., Douglas A.E.;
RT   "Functional and comparative genomic analyses of the Drosophila gut
RT   microbiota identify candidate symbiosis factors.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KID42449.1}.
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DR   EMBL; JOJZ01000009; KID42449.1; -; Genomic_DNA.
DR   RefSeq; WP_010022182.1; NZ_JQBI01000004.1.
DR   EnsemblBacteria; KID42449; KID42449; LfDm3_0378.
DR   PATRIC; fig|1614.10.peg.927; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   Proteomes; UP000031397; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031397};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031397}.
FT   NP_BIND     150    157       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   446 AA;  50100 MW;  6AA45659A988495F CRC64;
     MDQNELWDKI KNKFKADPKF EGTTYDTWIA TVKPIAYDGD TLTLELPSSL HRDYWEKMLK
     SQLVEYAYSI TYKNISPKFV LEEELQKESK PAAKPADGGQ DSYSYTDTHL EPNYTFETFV
     IGQGNKMAQA AALAVSESPG KLYNPLFLYG GVGLGKTHLM HAIGNNIVKH DPSQRVMYVT
     SEKFANDFIG AIQNNKMDEF RHVYRNVDVL LVDDIQFFGN KEGTQDEFFN TFQALYSNHK
     QIVLTSDRLP NEVPKLKDRL VSRFAWGLSV DITAPDLETR TAILRAKAKA DNMDIPADAL
     GYIASQIESN VRELEGALSR VQAYAKLNNA PIDTELVANA LRPLKLAKAR SALTVSDIIS
     KVASYYHISV KEIKGTKRVK AIVVPRQIAM YLSREMTDNS LPKIGDEFGG KDHTTVIHAY
     DKISRASAND SDLSKQISDI KTELQH
//
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