ID A0A0C1QRW5_9CYAN Unreviewed; 437 AA.
AC A0A0C1QRW5;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN Name=fahA {ECO:0000313|EMBL:KAF3890096.1};
GN ORFNames=DA73_0235100 {ECO:0000313|EMBL:KIE06583.1}, DA73_0400035050
GN {ECO:0000313|EMBL:KAF3890096.1};
OS Tolypothrix bouteillei VB521301.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Tolypothrichaceae;
OC Tolypothrix.
OX NCBI_TaxID=1479485 {ECO:0000313|EMBL:KIE06583.1};
RN [1] {ECO:0000313|EMBL:KIE06583.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VB521301 {ECO:0000313|EMBL:KIE06583.1};
RX PubMed=25700407;
RA Chandrababunaidu M.M., Singh D., Sen D., Bhan S., Das S., Gupta A.,
RA Adhikary S.P., Tripathy S.;
RT "Draft Genome Sequence of Tolypothrix boutellei Strain VB521301.";
RL Genome Announc. 3:e00001-15(2015).
RN [2] {ECO:0000313|EMBL:KAF3890096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VB521301 {ECO:0000313|EMBL:KAF3890096.1};
RA Sarangi A.N., Mukherjee M., Ghosh S., Singh D., Das A., Kant S., Prusty A.,
RA Tripathy S.;
RT "Improved Assembly of Tolypothrix boutellei genome.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE06583.1}.
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DR EMBL; JHEG04000001; KAF3890096.1; -; Genomic_DNA.
DR EMBL; JHEG02000059; KIE06583.1; -; Genomic_DNA.
DR RefSeq; WP_038082582.1; NZ_JHEG04000001.1.
DR AlphaFoldDB; A0A0C1QRW5; -.
DR STRING; 1479485.DA73_0235100; -.
DR OrthoDB; 9805307at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000029738; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KAF3890096.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000029738};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 30..130
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 139..390
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 437 AA; 47976 MW; 083ECC2C85E08F91 CRC64;
MSRLIDTTHD PNLHSWVESA NCKNTDFPIQ NLPFGVFQLS DSAELPRIGV AIGDQILDLF
LCLQTGLLQE LPEHLQAACG KSHLNPLMEL GSGASLMLRR HLSQLLQWNE RSPEAQQMLV
PMSHAKLLLP ASIGNYTDFY ASIFHATNVG KLFRPDNPLL PNYKHIPIAY HGRASSIIPS
DRAIARPKGQ RKSPEALTPS FEATQMLDYE LEVGFFVGVG NELGQPIPID TAEEHIFGLC
LVNDWSARDI QAWEYQPLGP FLAKSFATTV SPWVVTLEAL APFRTPAFKR APDDPLVLSY
LSSPADTTMG GVDIAVEALV RSLQMREAGI EPFRLSRGSF KDMYWTIAQM LTHHASNGCN
LHSGDLLASG TVSGTAIGSQ GCLLEITQRG ANPVELPTGE MRSFLLNDDE VILRGYCEKP
GFARIGFGEC RGAILPE
//
