ID A0A0C1UBU4_9ACTN Unreviewed; 431 AA.
AC A0A0C1UBU4;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nucleotide sugar dehydrogenase {ECO:0000313|EMBL:KIE49188.1};
GN ORFNames=MB54_05430 {ECO:0000313|EMBL:KIE49188.1};
OS marine actinobacterium MedAcidi-G2B.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1550401 {ECO:0000313|EMBL:KIE49188.1, ECO:0000313|Proteomes:UP000031352};
RN [1] {ECO:0000313|EMBL:KIE49188.1, ECO:0000313|Proteomes:UP000031352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mizuno C.M., Rodriguez-Valera F., Ghai R.;
RT "Novel reconstructed genomes of marine planktonic Acidimicrobiales.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000256|PIRNR:PIRNR000124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE49188.1}.
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DR EMBL; JUEO01000012; KIE49188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C1UBU4; -.
DR STRING; 1550401.MB54_05430; -.
DR Proteomes; UP000031352; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR PANTHER; PTHR43491; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR PANTHER; PTHR43491:SF5; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 322..415
FT /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00984"
SQ SEQUENCE 431 AA; 45513 MW; 8A275219E72858E2 CRC64;
MKAAVIGLGK IGLPIAVTIA DAGIEVVGGD ASQRVVDDVN NGREPFPGEP GLVEGIVRSL
DSGLLSATTS NSEASSGADV IVVIVPMYVD ESGVPDYSIL ESASRDIGTV LAPGQTVIYE
TTLPVGATRS HLAPVLEESS DLTAGEDFHV VHSPERVFSG RIFKDLRSYP KIVGGLTPLC
GQIAVSFYES VLNFDERPDL AQPNGVWDLG SVEAAEFTKL AETTYRDVNI ALANEFGDFA
ERLGVDVYQV IDAANSQPFS HIHRPGIYVG GHCIPVYPRF YSSVDEAALL PPLAREVNDA
GPERAVSRLE THLGSLEGAT VGVLGSTYRG GVKEMAFSGV FPLVESLEAR GALVSVHDPM
LSDGELEDLG FKPHILGGQV DAVIVQSDHP EYASLGPNDL GNPKAVVDGR KILNSIHFME
SSTALLTIGI G
//
