ID A0A0C1USP3_9CYAN Unreviewed; 1335 AA.
AC A0A0C1USP3;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=QQ91_019070 {ECO:0000313|EMBL:NEV69206.1};
OS Lyngbya confervoides BDU141951.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Lyngbya.
OX NCBI_TaxID=1574623 {ECO:0000313|EMBL:NEV69206.1, ECO:0000313|Proteomes:UP000031561};
RN [1] {ECO:0000313|EMBL:NEV69206.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69206.1};
RA Malar M.C., Sen D., Tripathy S.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NEV69206.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69206.1};
RX PubMed=25745003;
RA Chandrababunaidu M.M., Sen D., Tripathy S.;
RT "Draft Genome Sequence of Filamentous Marine Cyanobacterium Lyngbya
RT confervoides Strain BDU141951.";
RL Genome Announc. 3:e00066-e00015(2015).
RN [3] {ECO:0000313|EMBL:NEV69206.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69206.1};
RA Sarangi A.N., Ghosh S., Mukherjee M., Tripathy S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NEV69206.1}.
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DR EMBL; JTHE02000003; NEV69206.1; -; Genomic_DNA.
DR REBASE; 107886; Lco141951ORF30040P.
DR Proteomes; UP000031561; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:NEV69206.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 447..565
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 1335 AA; 152416 MW; AA8D5ED4D4D4C66B CRC64;
MRHSRNIFTT VRSEGAILPS DLLQRIVSGD KGLDGLDARS FHLLEGDRIN EAINRSWSRL
RGAWVNFQHA LTQLSSDDAA TRLTREKFLL PLFQELGYGR LPPASAIEIS GKRYAISHGW
HHTPIHLVGY RVDLDKRSAG IAGAAKSSPH SLVQELLNRS NQHLWAFLAN GRRLRILRDN
ASLTRQAYVE FDLEAMMAGE VYADFVLLWL LCHQSRVESE SPSRCWLERW SQVADSQGTR
ALEQLRKGVE VAISTLGQRF LSHPANQELR RLLQTGALSA QEYNHQLRRL VYRLLFLFVV
EDRDVLLDPA AAPEAKECYQ RYYSVNRLRS LADRHRGTRH HDLYLGLQVV MQHLGGEGCP
ALGLPALGSF LWSNEATPAL DGCQLANSAL LETVRALAFI CDRNGRRPVD YKNLQSRELG
SIYESLLELH PYLNIDAKTF KLETVEGNRR KTTGCYYTPE SLVQTLLRTT LNPVLDSATR
QPDPEAAILN LKICDTACGS GHFLTAAAQR MAKQLATLRT GDEEPGLDAV RTALRQVISR
CIYGVDVNRM AVELCKVALW MEAMEPGKPL PFLEHHIQWG NSLIGATPAL MARGIPDDVF
KPIRGDDKAL CRDLKRQNKR EREQAQLTLV DPSTRPWEWL EDMAAYAPEH QPWQQLEELA
AQMAELDGIP DETIAQVQLK QRKYQELLAS TEYRFSRFRA DSWCAAFVWR KTPGFDYALT
EEVFRKIKQN PYNAADWLWG EVENLQAQYH FFHWHVAFAH IFRVPKQAEA VEHEQAGWSG
GFDVELGNTP WERIKVQERE WFAAYRPDIS NSVNATQRKR KIQALKTEDP ELYGQFMERC
RQSDGESHFI HHSGKYPLCG RGDINTFAVF AEINRLLLQP NGRLGCIVPS SMATADTTKY
FFQDLMASKA LVSYYDFENR AKIFFPAVDS RMRFALMTLT GSQQPVEQAD FVFFAHRIED
LAQSDRHIHL TLDDINLLNP GTKTCPTFRS QREFAIARQV YQTIPVLGQS DHQGDRWQLR
ITQGLFSQTA DIGLLQPATA IDSDQTDLIR CYEARMISSF NHREGSAGIT DKNTFRTGVS
IAISDEERTD PHFLAQSRYW ASPQDTAQRL PKDYPYQWLM GFKDVTSATN TRTMIACVLP
KTAVLCSIRV VFLEDYRDAT PGGLLSLLAN WNSFCFDFFC RQSTPGNHLS DYIVRQLPTL
PPSTYQQPCP WDAVLTLEDW ILPRVLELTY TAWDLEGFAK DCGYEAAPFP WNLDRRSWLQ
AELDAAFFHL YSIQREDVDF MLESFPIVKR KDQQKLGCFQ TKSRILHIYD WLTTAIQSGS
AYHRNLEASM KDHFP
//
