ID A0A0C2B8I5_9ACTN Unreviewed; 619 AA.
AC A0A0C2B8I5;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KIF77640.1};
GN ORFNames=QR77_35020 {ECO:0000313|EMBL:KIF77640.1};
OS Streptomyces sp. 150FB.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1576605 {ECO:0000313|EMBL:KIF77640.1, ECO:0000313|Proteomes:UP000031584};
RN [1] {ECO:0000313|EMBL:KIF77640.1, ECO:0000313|Proteomes:UP000031584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=150FB {ECO:0000313|EMBL:KIF77640.1,
RC ECO:0000313|Proteomes:UP000031584};
RA Tarkka M.T., Feldhahn L., Kruger D., Buscot F., Wubet T.;
RT "Genome sequence of the mycoparasite antagonist Streptomyces sp. strain FB
RT 150.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIF77640.1}.
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DR EMBL; JTHL01000001; KIF77640.1; -; Genomic_DNA.
DR RefSeq; WP_040026033.1; NZ_JTHL01000001.1.
DR AlphaFoldDB; A0A0C2B8I5; -.
DR STRING; 1576605.QR77_35020; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000031584; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031584}.
FT DOMAIN 9..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..286
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 341..517
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 520..615
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 619 AA; 63596 MW; FA3E72247B2A5DC7 CRC64;
MDNSLFLPTV AVVGLGTMGT GIAEILARAG REVIGIDISD GAAARAVAAL EASTGRAVGR
GRLTEEERRS VLARFRTFSD LGAAAEAGLV IEVVPESYET KERVLRALDR VVAPTAILAT
GTNALSVTRL AAGSAHPERV LGLHFFNPAP AMKLVEVVSS VLTAPRAVAA VTALARELGK
EPVAVGDRPG FLADGLLFGY LNRAAAMYEA GYASREDIDA AMRLGCGLPM GPLALLDLIG
VDTARTVLEA LYDASRDRLH APAPILGQLG GAGLTGRKAG RGFYTYESPA GAAVVPDALT
ARATRALPAG RPVRTVGIAG SGTMAAGIAE VFARAGAGAS VGAGASAGAG ASAGAGAGAG
YDVVLAARTP RKAEAAVARV AASLDRSVGR GRLTAEAAAG ALARIVPAGS LDAFAEVDLV
VEAVTEELET KRRLFATLDK VCKPGAVLAT TTSSLPVIAC ARATSRPADV VGLHFFNPAP
AMKLVEVVRT VLTADDVHAT AREVTAAIRK HPVDCGDRAG FIVNALLFPY LNSAVKMVQE
HYATPDDIDT AMRLGGGYPM GPFELLDVVG LDVSLAIEQA LHREFRDPGL APAALLEHLV
AAGCLGRKTG RGFREHARR
//
