ID A0A0C2CYN5_9BILA Unreviewed; 1805 AA.
AC A0A0C2CYN5;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Integrase core domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ANCDUO_14914 {ECO:0000313|EMBL:KIH54937.1};
OS Ancylostoma duodenale.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH54937.1, ECO:0000313|Proteomes:UP000054047};
RN [1] {ECO:0000313|EMBL:KIH54937.1, ECO:0000313|Proteomes:UP000054047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zhejiang {ECO:0000313|EMBL:KIH54937.1,
RC ECO:0000313|Proteomes:UP000054047};
RA Mitreva M.;
RT "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN738206; KIH54937.1; -; Genomic_DNA.
DR Proteomes; UP000054047; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 1.20.5.1890; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00606; Glycoprotein_B; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054047};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 439..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 913..1091
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1475..1639
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 483..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1805 AA; 205644 MW; 90CB07B23D06DEC7 CRC64;
MRVDSDDTIT QAIAPDLCKN IAKSKRFYEK PLRRLHSGLY DTVEYGEIMS FDGHHMTSNL
GIMSGCDITE GKCTKNYGVI VWNPPTNGTR FCKYVKSTSA LMYISTNHVV SEEIQAVFHF
DNNNITAQQK QKLCIPASAE KMANGAFLHF PNLKISSRSN VREFLRNNAS EVRALGESQH
RESKTLRLTP YRSKRSITSL TNKGSNATDA LLMLSNDEAS PEARELAKHR FMNMFTETNN
GHLKNSYDQN QYELNVRTQF LSYRLQEQIS SNFRYLWAKI CHITNVQTRM LSFIVKTDPS
IVAKIMLDND DVSALLAGQV LLITQCKAVI ADEIIYSNKI NGKCYAHTPK YNELVFNSAP
IFHSELARLQ KMISISSKAK SYDDSLHHPN KDHHPDFLDD QLNALAADGL SYATTLEENA
KEVLQEGGTI ILEAISSRIM FIIIFVIFCI VFIITLGACY YLSCIRIAFR LFCRLFQPKN
QKRKQKSKNN SEHRMHTIDN GRIDNDSSHI SNHNVQAEEM ELQSGNPSYI SATTKFLTYI
PIALGFVGSV GANGNASPCF VPIFANEKSL TALFDTGSSI TFTSDHVLTH VIEGALHYED
VPPAKAANGG NIPFLGSSKV TITIGKITKT HKILVTCSKH CPAPFVLGTD FLATLRIPIR
MEFDRNRITI GSTTIPITQM STSFENEIYA VKIFEDITIP PRSDNYVIAQ INATFSDDDE
VIAEDLGSDA MPDGIFVGKT LFCPGTTRKF PLRILNTSNS SIKLYCDQRI AKAEIIHKSR
TRKVFSVHND TYNDPKQDSC ILAKNIRDQI DYIPPEVETE SFPITYSYSN IASLDKICWN
NSQLTLEQKS DIIQLVHEYH DIFLSSDGKI GRYNGPIRHR IDLINNANIP KQKPYRVPLE
QRTEIARQIQ ELLDQRIIEK SSSPFCAPII LVRKKDATWR FVVDYRKLNS ITKTETYLIP
NVQEIIDLTA GKTYYTTVDF KSGFHQIPMK KSHRERTAFQ TFLGLYQFIT MPMGLKGAPD
TFQKIANSLI RELKSCTFAY IDDIVTCSDD FAGHIVDIRE LFDRIRSFGM KLRLDKCVFA
AQEVEYLGVL ISKNGSRINP IRTEKIANFP VPTNVTSVKS FLGMASYFRR FIRNFAEIAS
PLCQLTTKDH RKFQWRREHQ SAFEELKKRL SSAPVLAAPI PGQPYEIHTD ASTKAVAGTL
LQTNPHNNEI HPIAFVSRCL TKHEKNYAII ELEALAIVFS LEKFRPYVFG AKIKVLTDHS
PLRSLLYRTE LNGRLAKYQI AIMGYDVTIE YRPGKQNTVS DALSRNPPLE KTVNTIVHSQ
LPTLDEVRAE QEKSPYFTRI QALRSEPEQI AENNDVTGND GTEENTRIVE NDEITRNGEA
ASRKRFCLHN DALFYFDGKN YRLVITNDEQ KRKVIEHHHD HIIDGGHRGI TKTLAKIRSR
FYWKNMNDQI KTFVRNCVIC QKVKSPPQYL NREKLGSFPS MNHPFQRVHS DVVGPLPMCI
NGNMYILIHT CAFTKYVICS AITDQQTKTI AKTFVNDVIC RYGVPEILIT DRGSNYTSEL
FKDIVEIIGV KHSLTTAYHH EANGQVERYV KTITDSLTCF VKDSRESWSD FLQLIVFAIN
TSQNETTGET PFFLMHGRDP KLISDNVFKM PRRTYFDHTS YKMELIHNLT VAWQNNEKRL
KSKTEIYKTN YDKSRDTNAS FLVGDLVLLR NDDNHPKFTE RWQGPYRITR METPNVSIQL
VGDPSKNDTV HLNRVKQFQS RDTFPVMVIP DHTATEVLEE EPMAITAPQR PKRTCRLRQR
AILNL
//